A Study of Emibetuzumab in Non Small Cell Lung Cancer (NSCLC) Participants



Status:Completed
Conditions:Lung Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:6/27/2018
Start Date:August 2013
End Date:March 2016

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A Randomized, Open-Label Phase 2 Study Evaluating LY2875358 Plus Erlotinib and LY2875358 Monotherapy in MET Diagnostic Positive NSCLC Patients With Acquired Resistance to Erlotinib

The primary purpose of this study is to evaluate the efficacy of the study drug known as
LY2875358, administered alone or in combination with a second drug named Erlotinib, in
participants affected by a defined type of lung cancer (MET biomarker diagnostic positive
Non-Small-Cell Lung Cancer) that experienced a disease progression during the most recent
treatment with Erlotinib.


Inclusion Criteria:

- Diagnosis of metastatic Stage IV NSCLC

- At least 1 measurable extra-central nervous system (CNS) lesion

- Documented radiographic progression while on continuous treatment with erlotinib
monotherapy

- Objective clinical benefit from erlotinib treatment as defined by either documented
partial or complete response or stable disease ≥6 months or, if most recent erlotinib
treatment has been initiated based on documented epidermal growth factor receptor
mutation (EGFRmt) status, at least 12 weeks stable disease

- Determined to be MET diagnostic positive (+)

- Availability of a tumor sample post-erlotinib progression

- Eastern Cooperative Oncology Group (ECOG) performance status ≤2

- Have adequate organ function

Exclusion Criteria:

- Are currently enrolled in, or discontinued within the last 30 days from, a clinical
trial involving an investigational product or non-approved use of a drug or device

- Have previously been treated with LY2875358 or any other MET-targeting experimental
therapeutic

- Have a serious concomitant systemic disorder or significant cardiac disease

- Have interstitial pneumonia or interstitial fibrosis of the lung or have pleural
effusion, pericardial fluids or ascites, requiring drainage every other week or more
frequently

- Have a history of another malignancy except for basal or squamous cell skin cancer
and/or in situ carcinoma of the cervix, or other solid tumors treated curatively and
without evidence of recurrence for at least 3 years prior to the study

- Have major surgery less than 2 weeks prior initiation of study treatment therapy

- Pregnant or lactating women

- Have symptomatic CNS metastasis
We found this trial at
33
sites
2042
mi
from 43215
Sacramento, CA
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201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
435
mi
from 43215
Atlanta, GA
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1045 North 30th Street
Billings, Montana 59101
406-255-8470
1345
mi
from 43215
Billings, MT
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
493
mi
from 43215
Birmingham, AL
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
643
mi
from 43215
Boston, MA
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1000 Blythe Blvd
Charlotte, North Carolina 28203
(704) 355-2000
349
mi
from 43215
Charlotte, NC
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3840 Broadway
Fort Myers, Florida 33901
(239) 275-6400
925
mi
from 43215
Fort Myers, FL
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116th St and Broadway
New York, New York 10027
(212) 854-1754
Columbia University In 1897, the university moved from Forty-ninth Street and Madison Avenue, where it...
481
mi
from 43215
New York, NY
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825 Eastlake Ave E
Seattle, Washington 98109
(206) 288-7222
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
2006
mi
from 43215
Seattle, WA
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4037
mi
from 43215
Aalst,
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Athens, Georgia 30607
411
mi
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Athens, GA
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1154
mi
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Aurora, CO
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Chattanooga, Tennessee 37404
362
mi
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Chattanooga, TN
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5053 Wooster Rd
Cincinnati, Ohio 45226
(513) 751-2273
Oncology Hematology Care Our more than 60 physicians and advanced practice providers throughout neighborhood offices...
86
mi
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Cincinnati, OH
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Detroit, Michigan 48201
164
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Detroit, MI
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Iowa City, Iowa 52242
460
mi
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Iowa City, IA
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Kirkland, Washington 98034
2000
mi
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Kirkland, WA
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9500 Gilman Dr
La Jolla, California 92093
(858) 534-2230
The University of California, San Diego UC San Diego is an academic powerhouse and economic...
1953
mi
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La Jolla, CA
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1 Medical Center Dr
Lebanon, New Hampshire 03756
 (603) 650-5000
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
609
mi
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Lebanon, NH
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1972
mi
from 43215
Los Angeles, CA
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100 N Humphreys Blvd
Memphis, Tennessee 38120
(901) 683-0055
The West Clinic, PC Hello and welcome to our office. Although it is our pleasure...
502
mi
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Memphis, TN
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250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
348
mi
from 43215
Nashville, TN
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Philadelphia, Pennsylvania 19111
420
mi
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Philadelphia, PA
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Portland, Oregon 97239
2027
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Portland, OR
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Rochester, Minnesota 55905
559
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Rochester, MN
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Saint Louis, Missouri 63110
397
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Saint Louis, MO
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Saint Petersburg, Florida 33705
845
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Saint Petersburg, FL
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Santa Monica, California 90404
1982
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Santa Monica, CA
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Seattle, Washington 98124
2006
mi
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Seattle, WA
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314 Martin Luther King Junior Way
Tacoma, Washington 98405
(253) 403-5200
Multicare Health System MultiCare is a not-for-profit health care organization with more than 10,000 employees...
1996
mi
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Tacoma, WA
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Tampa, Florida 33612
823
mi
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Tampa, FL
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Washington, District of Columbia 20007
325
mi
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Washington,
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Westwood, Kansas 66205
620
mi
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Westwood, KS
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