Vitamin D Supplementation in Glomerular Disease

Vitamin D deficiency has been linked to a variety of adverse health outcomes. Nephrotic
patients have very low vitamin D levels, and the underlying mechanisms are not known.
Furthermore, approaches to safely and effectively supplement vitamin D in these patients have
not been established. The purpose of this research study is to learn if vitamin D
supplementation is safe and effective in patients with primary glomerular disease and to also
help establish the treatment guidelines. About 35 patients with primary glomerular disease,
ages 5-30 years old, will take part in this study. Participants will be asked to take vitamin
D supplements each day for 12 weeks and will have 3 study visits.

Inclusion Criteria:

- Males or females, age 5-30 years

- Diagnosis of primary glomerular disease (such as steroid-resistant nephrotic syndrome,
minimal change disease, FSGS, membranous nephropathy, membranoprolfierative
glomerulonephritis, and Immunoglobulin A [IgA] nephropathy) without systemic
inflammatory disorders (i.e. lupus, vasculitis)

- Serum 25(OH)D level <30 ng/ml and urine protein:creatinine ratio ≥0.5 at Screening
Visit.

Exclusion Criteria:

- Pregnancy

- estimated Glomerular Filtration Rate (eGFR) <30 ml/min/1.73m2 at Screening Visit

- Serum phosphorus > 5.5 mg/dl or hypercalcemia

- Chronic medical conditions or medications unrelated to the renal disease that may
impact vitamin D status

- Known history of kidney stone(s)