A Safety Study of SGN-CD19A for Leukemia and Lymphoma
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Blood Cancer, Lymphoma |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 1 - Any |
| Updated: | 2/4/2017 |
| Start Date: | February 2013 |
| End Date: | May 2019 |
A Phase 1, Open-Label, Dose-Escalation Study of SGN-CD19A in Patients With B-Lineage Acute Lymphoblastic Leukemia and Highly Aggressive Lymphomas
This is a phase 1, open-label, dose-escalation, multicenter study to evaluate the safety and
tolerability of SGN-CD19A in adult and pediatric patients with relapsed or refractory
B-lineage acute lymphoblastic leukemia (B-ALL), Burkitt lymphoma or leukemia, or B-lineage
lymphoblastic lymphoma (B-LBL).
tolerability of SGN-CD19A in adult and pediatric patients with relapsed or refractory
B-lineage acute lymphoblastic leukemia (B-ALL), Burkitt lymphoma or leukemia, or B-lineage
lymphoblastic lymphoma (B-LBL).
Inclusion Criteria:
- Adult patients must be relapsed or refractory to at least 1 prior multi-agent
systemic therapy. Pediatric patients must be relapsed or refractory to at least 2
prior multi-agent systemic therapies. Patients with acute lymphoblastic leukemia who
are Philadelphia chromosome-positive must have failed a second generation tyrosine
kinase inhibitor.
- Eastern Cooperative Oncology Group status of 2 or lower
- Pathologically confirmed diagnosis of B-lineage acute lymphoblastic leukemia, Burkitt
leukemia or lymphoma, or B-lineage lymphoblastic lymphoma
- Measurable disease
Exclusion Criteria:
- Allogeneic stem cell transplant within 60 days, active acute or chronic
graft-versus-host disease (GvHD), or receiving immunosuppressive therapy as treatment
for GvHD
We found this trial at
13
sites
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University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
Cincinnati, Ohio 45229
1-513-636-4200
Cincinnati Children's Hospital Medical Center Patients and families from across the region and around the...
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12902 USF Magnolia Dr
Tampa, Florida 33612
Tampa, Florida 33612
(888) 663-3488
H. Lee Moffitt Cancer Center & Research Institute Moffitt Cancer Center in Tampa, Florida, has...
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Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boston Children's Hospital Boston Children's Hospital is a 395-bed comprehensive center for pediatric health care....
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1500 East Duarte Road
Duarte, California 91010
Duarte, California 91010
626-256-HOPE (4673)
City of Hope National Medical Center City of Hope is dedicated to making a difference...
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Mayo Clinic Florida Thousands of people come to Mayo Clinic in Jacksonville, Fla., annually for...
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Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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Mayo Clinic Arizona Mayo Clinic in Arizona provides medical care for thousands of people from...
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All Children's Hospital All Children's Hospital provides expert pediatric care for children and families from...
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