Study of a Melanoma Vaccine in Stage IIb, IIc, and III Melanoma Patients



Status:Active, not recruiting
Conditions:Skin Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 80
Updated:9/8/2017
Start Date:April 2012
End Date:June 30, 2019

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A Multicenter, Double-blind, Placebo-controlled, Adaptive Phase 3 Trial of POL-103A Polyvalent Melanoma Vaccine in Post-resection Melanoma Patients With a High Risk of Recurrence

The purpose of this study is to determine how safe and how well POL-103A works in preventing
the relapse of melanoma after patients who have undergone surgery.


Inclusion Criteria:

- Histologically confirmed Stage IIb, IIc, III melanoma

- Surgical resection within 90 days of first dosing

- Persons with positive sentinel nodes must have a complete lymphadenectomy

- ECOG performance status 0 or 1

Exclusion Criteria:

- Any prior melanoma treatment other than surgery or regional irradiation

- Diagnosis of non-cutaneous melanoma or melanoma with unknown primary origin

- Use of biologic response modifiers within 60 days of first dosing

- Subjects with history of other malignancy within past 5 years (with exceptions)
We found this trial at
73
sites
Niles, Illinois 60714
Principal Investigator: Sigrun Hallmeyer, MD
Phone: 847-410-0667
1722
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Niles, IL
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One Medical Center Drive
Lebanon, New Hampshire 03756
(603) 653-9000
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center Norris Cotton Cancer Center at DHMC in...
2515
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Lebanon, NH
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529 West Markham Street
Little Rock, Arkansas 72205
(501) 686-7000
Principal Investigator: Laura Hutchins, MD
Phone: 501-686-8274
University of Arkansas for Medical Sciences The University of Arkansas for Medical Sciences (UAMS) in...
1461
mi
from 91732
Little Rock, AR
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1400 South Orange Avenue
Orlando, Florida 32806
(407) 648-3800
Principal Investigator: Sajeve Thomas, MD
Phone: 321-841-7303
M.D. Anderson Cancer Center at Orlando For more than twenty years, our cancer center has...
2184
mi
from 91732
Orlando, FL
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725 West Granada Blvd
Ormond Beach, Florida 32174
386-898-0547
Principal Investigator: James Solomon, MD
2185
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Ormond Beach, FL
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4805 Northeast Glisan Street
Portland, Oregon 97213
(503) 215-1111
Principal Investigator: Brendan Curti, MD
Phone: 503-215-2691
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
827
mi
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Portland, OR
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
827
mi
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Portland, OR
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Aurora, Colorado 80045
Principal Investigator: Karl Lewis, MD
Phone: 720-848-0746
825
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Aurora, CO
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Baltimore, Maryland 21237
Principal Investigator: Pallavi Kumar, MD
Phone: 443-777-8876
2307
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Baltimore, MD
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Bend, Oregon 97701
Principal Investigator: William Schmidt, MD
Phone: 541-706-6592
711
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Bend, OR
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Beverly Hills, California 90211
21
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Beverly Hills, CA
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Boca Raton, Florida 33486
Principal Investigator: Marta Rendon, MD
Phone: 561-750-0544
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Boca Raton, FL
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Centennial, Colorado 80112
818
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Centennial, CO
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Chandler, Arizona 85224
Principal Investigator: Sujith Kalmadi, MD
Phone: 602-494-6828
356
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Chandler, AZ
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Charlottesville, Virginia 22908
Principal Investigator: Craig Slingluff, MD
Phone: 434-982-1902
2208
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Charlottesville, VA
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18101 Lorain Avenue
Cleveland, Ohio 44111
2025
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Cleveland, OH
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2049 E 100th St
Cleveland, Ohio 44106
(216) 444-2200
Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
2033
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Cleveland, OH
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8196 Walnut Hill Lane
Dallas, Texas 75231
1225
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Dallas, TX
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3310 Live Oak St
Dallas, Texas 75204
(214) 820-2687
Baylor Research Institute Baylor Research Institute (BRI) is a dedicated research center for finding prevention...
1225
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Dallas, TX
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4035 Colonel Glenn Highway
Dayton, Ohio 45431
1903
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Dayton, OH
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Doral, Florida 33166
2314
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Doral, FL
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Duarte, California 91010
5
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Duarte, CA
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8505 Arlington Boulevard
Fairfax, Virginia 22031
2270
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Fairfax, VA
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Fayetteville, Arkansas 72703
Principal Investigator: Thaddeus Beck, MD
Phone: 479-695-4168
1354
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Fayetteville, AR
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1743
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Germantown, TN
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Greenville, North Carolina 27834
Principal Investigator: Prashanti Atluri, MD
Phone: 252-744-5723
2290
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Greenville, NC
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92 2nd Street
Hackensack, New Jersey 07601
2429
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Hackensack, NJ
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Hot Springs, Arkansas 71913
Principal Investigator: Dowling Stough, MD
Phone: 501-620-4449
1419
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Hot Springs, AR
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1401 Binz Street
Houston, Texas 77004
1357
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Houston, TX
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5001 Rockside Road, Crown Center II
Independence, Ohio 44131
2033
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Independence, OH
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Indianapolis, Indiana 46254
Principal Investigator: Stephen Schultz, MD
Phone: 317-297-2208
1787
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Indianapolis, IN
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200 Hawkins Dr,
Iowa City, Iowa 52242
866-452-8507
Principal Investigator: Mohammed Milhem, MD
Phone: 319-356-1228
University of Iowa Hospitals and Clinics University of Iowa Hospitals and Clinics—recognized as one of...
1528
mi
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Iowa City, IA
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Jacksonville, Florida 32256
Principal Investigator: Suprith Badarinath, MD
Phone: 904-388-2619
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Jacksonville, FL
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Jacksonville, Florida 32256
2138
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Jacksonville, FL
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Kansas City, Missouri 64114
Principal Investigator: John Ervin, MD
Phone: 816-943-0770
1339
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Kansas City, MO
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Knoxville, Tennessee 37920
Principal Investigator: Timothy Panella, MD
Phone: 865-305-5281
1925
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Knoxville, TN
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Lake Charles, Louisiana 70601
Principal Investigator: Shondra Smith, MD
Phone: 337-477-0011
1471
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Lake Charles, LA
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Lexington, Kentucky 40509
1886
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Lexington, KY
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Lexington, Kentucky 40503
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Lexington, KY
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1551 Professional Lane
Longmont, Colorado 80501
824
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Longmont, CO
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Los Angeles, California 90025
Principal Investigator: Omid Hamid, MD
Phone: 310-582-7900
13
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Los Angeles, CA
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Los Angeles, California 90095
24
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Los Angeles, CA
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500 S Preston St
Louisville, Kentucky
(502) 852-5555
Principal Investigator: Prejesh Phillips, MD
Phone: 502-629-3384
University of Louisville The University of Louisville is a state supported research university located in...
1812
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Louisville, KY
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Mayfield Heights, Ohio 44124
2044
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Mayfield Heights, OH
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Miami Beach, Florida 33140
Principal Investigator: Jose Lutzky, MD
Phone: 305-674-2121
2324
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Miami Beach, FL
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Miami Lakes, Florida 33014
Principal Investigator: Jose Perez, DO
Phone: 786-362-5763
2311
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Miami Lakes, FL
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Minneapolis, Minnesota 55455
Principal Investigator: Venkatesh Rudrapatna, MD
Phone: 612-626-5369
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Minneapolis, MN
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5121 S Cottonwood St
Murray, Utah 84157
(801) 507-7000
Principal Investigator: Tawnya Bowles, MD
Phone: 801-507-3951
Intermountain Medical Center Intermountain Medical Center is one of the most technologically advanced and patient-friendly...
565
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Murray, UT
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New Brunswick, New Jersey 08901
2410
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New Brunswick, NJ
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New York, New York 10029
2435
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New York, NY
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Oxnard, California 93030
Principal Investigator: Lynn Kong, MD
Phone: 805-485-8709
67
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Oxnard, CA
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130 South 9th Street
Philadelphia, Pennsylvania 19107
2375
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Philadelphia, PA
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Phoenix, Arizona 85108
Principal Investigator: Andrew Racette, DO
Phone: 480-889-1211
348
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Phoenix, AZ
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Phoenix, Arizona 85032
Principal Investigator: Sadra Jazayeri, MD
Phone: 602-971-0268
345
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Phoenix, AZ
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Rochester, Minnesota 55905
Principal Investigator: Svetomir Markovic, MD, PhD
Phone: 507-284-2041
1525
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Rochester, MN
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Sacramento, California 95816
Principal Investigator: Deepti Behl, MD
Phone: 916-454-6931
365
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Sacramento, CA
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1419 Village Drive
Saint Joseph, Missouri 64506
1337
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Saint Joseph, MO
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321 South Newstead Avenue
Saint Louis, Missouri 63110
1569
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Saint Louis, MO
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660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
1569
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Saint Louis, MO
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2000 Circle of Hope Dr
Salt Lake City, Utah 84112
(801) 585-0303
Principal Investigator: Robert Andtbacka, MD
Phone: 801-213-4323
Huntsman Cancer Institute at University of Utah Huntsman Cancer Institute (HCI) is part of the...
573
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Salt Lake City, UT
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San Francisco, California 94117
Principal Investigator: Lynn Spitler, MD
Phone: 415-750-4060
355
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San Francisco, CA
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Seattle, Washington 98101
(888) 862-2737
Principal Investigator: Prakash Vishnu, MD
Phone: 206-223-6892
Virginia Mason Medical Center Established in 1920, Virginia Mason began as an 80-bed hospital with...
961
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Seattle, WA
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Southfield, Michigan 48075
Principal Investigator: Howard Terebelo, DO
Phone: 248-849-5330
1958
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Southfield, MI
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801 N Rutledge St
Springfield, Illinois 62702
(217) 545-8000
Southern Illinois University School of Medicine At SIU School of Medicine, research includes biologically oriented...
1608
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Springfield, IL
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Tacoma, Washington 98405
Principal Investigator: John Keech, DO
Phone: 253-403-2314
939
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Tacoma, WA
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Tampa, Florida 33609
2133
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Tampa, FL
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Temecula, California 92592
Principal Investigator: Jesse Mitchell, MD
Phone: 951-303-6900
63
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Temecula, CA
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Tucson, Arizona 85724
Principal Investigator: Lee Cranmer, MD
Phone: 520-694-9056
427
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Tucson, AZ
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2410 Lee Avenue
Victoria, British Columbia V8R 6V5
1029
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Victoria,
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110 Irving Street Northwest
Washington, D.C., District of Columbia 20010
2282
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Washington, D.C.,
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Webster, Texas 77598
Principal Investigator: Patricia Lee, MD
Phone: 281-333-2288
1377
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Webster, TX
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West Reading, Pennsylvania 19611
2332
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West Reading, PA
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Winston-Salem, North Carolina 27157
Principal Investigator: Edward Levine, MD
Phone: 336-713-3155
2126
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Winston-Salem, NC
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