Study of a Melanoma Vaccine in Stage IIb, IIc, and III Melanoma Patients



Status:Active, not recruiting
Conditions:Skin Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 80
Updated:9/8/2017
Start Date:April 2012
End Date:June 30, 2019

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A Multicenter, Double-blind, Placebo-controlled, Adaptive Phase 3 Trial of POL-103A Polyvalent Melanoma Vaccine in Post-resection Melanoma Patients With a High Risk of Recurrence

The purpose of this study is to determine how safe and how well POL-103A works in preventing
the relapse of melanoma after patients who have undergone surgery.


Inclusion Criteria:

- Histologically confirmed Stage IIb, IIc, III melanoma

- Surgical resection within 90 days of first dosing

- Persons with positive sentinel nodes must have a complete lymphadenectomy

- ECOG performance status 0 or 1

Exclusion Criteria:

- Any prior melanoma treatment other than surgery or regional irradiation

- Diagnosis of non-cutaneous melanoma or melanoma with unknown primary origin

- Use of biologic response modifiers within 60 days of first dosing

- Subjects with history of other malignancy within past 5 years (with exceptions)
We found this trial at
73
sites
529 West Markham Street
Little Rock, Arkansas 72205
(501) 686-7000
Principal Investigator: Laura Hutchins, MD
Phone: 501-686-8274
University of Arkansas for Medical Sciences The University of Arkansas for Medical Sciences (UAMS) in...
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One Medical Center Drive
Lebanon, New Hampshire 03756
(603) 653-9000
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center Norris Cotton Cancer Center at DHMC in...
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Lebanon, NH
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1400 South Orange Avenue
Orlando, Florida 32806
(407) 648-3800
Principal Investigator: Sajeve Thomas, MD
Phone: 321-841-7303
M.D. Anderson Cancer Center at Orlando For more than twenty years, our cancer center has...
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Orlando, FL
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725 West Granada Blvd
Ormond Beach, Florida 32174
386-898-0547
Principal Investigator: James Solomon, MD
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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Portland, OR
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4805 Northeast Glisan Street
Portland, Oregon 97213
(503) 215-1111
Principal Investigator: Brendan Curti, MD
Phone: 503-215-2691
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
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Portland, OR
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Aurora, Colorado 80045
Principal Investigator: Karl Lewis, MD
Phone: 720-848-0746
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Baltimore, Maryland 21237
Principal Investigator: Pallavi Kumar, MD
Phone: 443-777-8876
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Bend, Oregon 97701
Principal Investigator: William Schmidt, MD
Phone: 541-706-6592
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Beverly Hills, California 90211
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Boca Raton, Florida 33486
Principal Investigator: Marta Rendon, MD
Phone: 561-750-0544
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Centennial, Colorado 80112
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Chandler, Arizona 85224
Principal Investigator: Sujith Kalmadi, MD
Phone: 602-494-6828
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Charlottesville, Virginia 22908
Principal Investigator: Craig Slingluff, MD
Phone: 434-982-1902
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2049 E 100th St
Cleveland, Ohio 44106
(216) 444-2200
Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
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18101 Lorain Avenue
Cleveland, Ohio 44111
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3310 Live Oak St
Dallas, Texas 75204
(214) 820-2687
Baylor Research Institute Baylor Research Institute (BRI) is a dedicated research center for finding prevention...
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8196 Walnut Hill Lane
Dallas, Texas 75231
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4035 Colonel Glenn Highway
Dayton, Ohio 45431
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Doral, Florida 33166
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Duarte, California 91010
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8505 Arlington Boulevard
Fairfax, Virginia 22031
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Fayetteville, Arkansas 72703
Principal Investigator: Thaddeus Beck, MD
Phone: 479-695-4168
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Germantown, TN
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Greenville, North Carolina 27834
Principal Investigator: Prashanti Atluri, MD
Phone: 252-744-5723
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92 2nd Street
Hackensack, New Jersey 07601
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Hot Springs, Arkansas 71913
Principal Investigator: Dowling Stough, MD
Phone: 501-620-4449
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1401 Binz Street
Houston, Texas 77004
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5001 Rockside Road, Crown Center II
Independence, Ohio 44131
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Indianapolis, Indiana 46254
Principal Investigator: Stephen Schultz, MD
Phone: 317-297-2208
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200 Hawkins Dr,
Iowa City, Iowa 52242
866-452-8507
Principal Investigator: Mohammed Milhem, MD
Phone: 319-356-1228
University of Iowa Hospitals and Clinics University of Iowa Hospitals and Clinics—recognized as one of...
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Jacksonville, Florida 32256
Principal Investigator: Suprith Badarinath, MD
Phone: 904-388-2619
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Jacksonville, Florida 32256
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Kansas City, Missouri 64114
Principal Investigator: John Ervin, MD
Phone: 816-943-0770
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Knoxville, Tennessee 37920
Principal Investigator: Timothy Panella, MD
Phone: 865-305-5281
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Lake Charles, Louisiana 70601
Principal Investigator: Shondra Smith, MD
Phone: 337-477-0011
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Lexington, Kentucky 40509
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Lexington, Kentucky 40503
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1551 Professional Lane
Longmont, Colorado 80501
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Los Angeles, California 90025
Principal Investigator: Omid Hamid, MD
Phone: 310-582-7900
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Los Angeles, California 90095
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500 S Preston St
Louisville, Kentucky
(502) 852-5555
Principal Investigator: Prejesh Phillips, MD
Phone: 502-629-3384
University of Louisville The University of Louisville is a state supported research university located in...
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Mayfield Heights, Ohio 44124
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Miami Beach, Florida 33140
Principal Investigator: Jose Lutzky, MD
Phone: 305-674-2121
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Miami Lakes, Florida 33014
Principal Investigator: Jose Perez, DO
Phone: 786-362-5763
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Minneapolis, Minnesota 55455
Principal Investigator: Venkatesh Rudrapatna, MD
Phone: 612-626-5369
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5121 S Cottonwood St
Murray, Utah 84157
(801) 507-7000
Principal Investigator: Tawnya Bowles, MD
Phone: 801-507-3951
Intermountain Medical Center Intermountain Medical Center is one of the most technologically advanced and patient-friendly...
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New Brunswick, New Jersey 08901
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New York, New York 10029
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Niles, Illinois 60714
Principal Investigator: Sigrun Hallmeyer, MD
Phone: 847-410-0667
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Oxnard, California 93030
Principal Investigator: Lynn Kong, MD
Phone: 805-485-8709
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130 South 9th Street
Philadelphia, Pennsylvania 19107
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Phoenix, Arizona 85108
Principal Investigator: Andrew Racette, DO
Phone: 480-889-1211
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Phoenix, Arizona 85032
Principal Investigator: Sadra Jazayeri, MD
Phone: 602-971-0268
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Rochester, Minnesota 55905
Principal Investigator: Svetomir Markovic, MD, PhD
Phone: 507-284-2041
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Sacramento, California 95816
Principal Investigator: Deepti Behl, MD
Phone: 916-454-6931
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1419 Village Drive
Saint Joseph, Missouri 64506
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660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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321 South Newstead Avenue
Saint Louis, Missouri 63110
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2000 Circle of Hope Dr
Salt Lake City, Utah 84112
(801) 585-0303
Principal Investigator: Robert Andtbacka, MD
Phone: 801-213-4323
Huntsman Cancer Institute at University of Utah Huntsman Cancer Institute (HCI) is part of the...
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San Francisco, California 94117
Principal Investigator: Lynn Spitler, MD
Phone: 415-750-4060
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Seattle, Washington 98101
(888) 862-2737
Principal Investigator: Prakash Vishnu, MD
Phone: 206-223-6892
Virginia Mason Medical Center Established in 1920, Virginia Mason began as an 80-bed hospital with...
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Southfield, Michigan 48075
Principal Investigator: Howard Terebelo, DO
Phone: 248-849-5330
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801 N Rutledge St
Springfield, Illinois 62702
(217) 545-8000
Southern Illinois University School of Medicine At SIU School of Medicine, research includes biologically oriented...
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Tacoma, Washington 98405
Principal Investigator: John Keech, DO
Phone: 253-403-2314
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Tampa, Florida 33609
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Temecula, California 92592
Principal Investigator: Jesse Mitchell, MD
Phone: 951-303-6900
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Tucson, Arizona 85724
Principal Investigator: Lee Cranmer, MD
Phone: 520-694-9056
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2410 Lee Avenue
Victoria, British Columbia V8R 6V5
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110 Irving Street Northwest
Washington, D.C., District of Columbia 20010
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Webster, Texas 77598
Principal Investigator: Patricia Lee, MD
Phone: 281-333-2288
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West Reading, Pennsylvania 19611
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Winston-Salem, North Carolina 27157
Principal Investigator: Edward Levine, MD
Phone: 336-713-3155
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