LIPS-A: Lung Injury Prevention Study With Aspirin



Status:Recruiting
Conditions:Hospital, Pulmonary
Therapuetic Areas:Pulmonary / Respiratory Diseases, Other
Healthy:No
Age Range:18 - Any
Updated:4/2/2016
Start Date:January 2012
End Date:August 2016

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This is a multi-center, phase, phase II double-blind, placebo-controled, randomized trial of
aspirin for the prevention of acute lung injury in patients identified as at risk for acute
lung injury.


Inclusion Criteria:

- Adult patients (age > 18) admitted to the hospital through the emergency department
(ED)

- At high risk of developing ALI (Lung Injury Prediction Score-LIPS greater than or
equal to 4)

Exclusion Criteria:

- Anti-platelet therapy on admission or within 7 days prior to admission

- Presented to outside hospital ED > 12 hrs before arrival at site's facility

- Inability to obtain consent within 12 hours of hospital presentation

- Admitted for elective surgery

- Acute lung injury prior to randomization

- Receiving mechanical ventilation through a tracheostomy tube prior to current
hospital admission (patient who is ventilator dependent)

- Presence of bilateral pulmonary infiltrates on admission if he or she has a history
of bilateral pulmonary infiltrates (as evidenced by previous x-rays) that can
reasonably explain the current degree of pulmonary infiltrates present.

- Presentation due to pure heart failure and no other known risk factors for ALI.

- Allergy to aspirin or non steroidal anti inflammatory drugs (NSAID's)

- Bleeding disorder

- Suspected active bleeding or judged to be at high risk for bleeding

- Active peptic ulcer disease (within past 6 months)

- Severe chronic liver disease

- Inability to administer the study drug

- Expected hospital stay < 48 hours

- Admitted for comfort or hospice care

- Patient, surrogate or physician not committed to full support (Exception: a patient
will not be excluded if he/she would receive all supportive care except for attempts
at resuscitation from cardiac arrest)

- Not anticipated to survive > 48 hours

- Previously enrolled in this trial

- Enrolled in a concomitant intervention trial

- Pregnant or breastfeeding
We found this trial at
16
sites
325 9th Ave
Seattle, Washington 98104
(206) 744-3300
Harborview Medical Center Harborview Medical Center is the only designated Level 1 adult and pediatric...
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Seattle, WA
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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Boston, MA
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75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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Boston, MA
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330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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Boston, MA
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3550 Jerome Avenue
Bronx, New York 10467
(718) 920-4321
Montefiore Medical Center As the academic medical center and University Hospital for Albert Einstein College...
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Bronx, NY
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500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
University of Michigan The University of Michigan was founded in 1817 as one of the...
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Ann Arbor, MI
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Bridgeport, Connecticut 06610
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Bridgeport, CT
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2035 W Taylor St
Chicago, Illinois
(312) 996-4350
University of Illinois at Chicago A major research university in the heart of one of...
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Chicago, IL
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2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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Durham, NC
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205 Matherly hall
Gainsville, Florida 32611
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Gainsville, FL
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4500 San Pablo Rd S
Jacksonville, Florida 32224
(904) 953-2000
Mayo Clinic Florida Thousands of people come to Mayo Clinic in Jacksonville, Fla., annually for...
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Jacksonville, FL
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Louisville, Kentucky 40202
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Louisville, KY
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Philadelphia, Pennsylvania 19140
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Philadelphia, PA
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200 First Street SW
Rochester, Minnesota 55905
507-284-2511
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
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Rochester, MN
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Stanford, California 94305
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Stanford, CA
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Winston Salem, North Carolina 27157
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Winston Salem, NC
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