The BEACON Study (Breast Cancer Outcomes With NKTR-102)



Status:Active, not recruiting
Conditions:Breast Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:December 2011

Use our guide to learn which trials are right for you!

The BEACON Study (Breast Cancer Outcomes With NKTR-102): A Phase 3 Open-Label, Randomized, Multicenter Study of NKTR-102 Versus Treatment of Physician's Choice (TPC) in Patients With Locally Recurrent or Metastatic Breast Cancer Previously Treated With an Anthracycline, a Taxane and Capecitabine

The study is designed as an open-label, randomized, parallel, two arm, multicenter,
international Phase 3 study in patients with recurrent or metastatic breast cancer
previously treated with cytotoxic chemotherapy regimens.

The primary study objective is to compare overall survival of patients who receive NKTR-102
given once every 21 days to patients who receive treatment of Physician's Choice selected
from a list of seven single-agent intravenous therapies.


Inclusion Criteria (major highlights):

- Patient is an adult female with histologically or cytologically confirmed carcinoma
of the breast for whom single-agent cytotoxic chemotherapy is indicated

- Patient can have either measurable or non-measurable disease by RECIST.

- Patient has received prior therapy (administered in the neoadjuvant, adjuvant and/or
metastatic setting) with an anthracycline, a taxane and capecitabine

- Patient has minimum of 2 and a maximum of 5 prior cytotoxic chemotherapy regimens
with the last dose administered within 6 months. A minimum of two chemotherapy
regimens had to be for locally recurrent and/or metastatic disease. All therapy
received prior to a diagnosis of metastatic disease (eg, neoadjuvant, adjuvant or
repeated adjuvant therapy following a second resection) is counted as one regimen.

- Patient has Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

- Adequate hematopoietic, liver and kidney functions.

Exclusion Criteria (major highlights):

- Patient with chemotherapy within 21 days, radiotherapy within 14 days, biological
therapy with 14 days, hormonal therapy within 7 days and investigational therapy
within 21 days prior to randomization.

- Patient with any major surgery within 28 days prior to randomization.

- Patient with concurrent use of biologic agents for the treatment of cancer including
antibodies or any investigational agent(s).

- Patient with prior treatment for cancer with a camptothecin derivative.

- Patient with chronic or acute GI disorders resulting in diarrhea of any severity
grade; patients who are using chronic anti-diarrheal supportive care to control
diarrhea in the 28 days prior to randomization.

- Patient received pharmacotherapy for hepatitis B or C, tuberculosis or HIV.

- Patient with known cirrhosis diagnosed with Child-PUGH Class A or higher liver
disease.

- Patient with prior malignancy (other than breast cancer) except for non-melanoma skin
cancer and carcinoma in situ (of the cervix or bladder), unless diagnosed and
definitively treated more than 5 years prior to randomization.

- Patient requiring daily use of oxygen supplementation in the 28 days prior to
randomization.

- Patients with significant cardiovascular impairment.
We found this trial at
89
sites
Durham, North Carolina 27710
?
mi
from
Durham, NC
Click here to add this to my saved trials
201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Los Angeles, California 90033
213) 740-2311
University of Southern California The University of Southern California is one of the world’s leading...
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
8940 N Kendall Dr # 300E
Miami, Florida 33176
?
mi
from
Miami, FL
Click here to add this to my saved trials
Minneapolis, Minnesota 55455
(612) 625-5000
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
?
mi
from
Minneapolis, MN
Click here to add this to my saved trials
825 Eastlake Ave E
Seattle, Washington 98109
(206) 288-7222
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
?
mi
from
Seattle, WA
Click here to add this to my saved trials
291 Campus Dr
Stanford, California 94305
(650) 725-3900
Stanford University School of Medicine Vast in both its physical scale and its impact on...
?
mi
from
Stanford, CA
Click here to add this to my saved trials
Abilene, Texas 79606
?
mi
from
Abilene, TX
Click here to add this to my saved trials
Albany, New York 12206
?
mi
from
Albany, NY
Click here to add this to my saved trials
Albuquerque, New Mexico 87106
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
Athens, Georgia 30607
?
mi
from
Athens, GA
Click here to add this to my saved trials
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Austin, Texas 78705
?
mi
from
Austin, TX
Click here to add this to my saved trials
?
mi
from
Beaumont, TX
Click here to add this to my saved trials
Bedford, Texas 76022
?
mi
from
Bedford, TX
Click here to add this to my saved trials
?
mi
from
Billings, MT
Click here to add this to my saved trials
?
mi
from
Bronx, NY
Click here to add this to my saved trials
Bronx, New York 10461
?
mi
from
Bronx, NY
Click here to add this to my saved trials
?
mi
from
Bruxelles,
Click here to add this to my saved trials
?
mi
from
Burbank, CA
Click here to add this to my saved trials
Cedar Rapids, Iowa 52403
?
mi
from
Cedar Rapids, IA
Click here to add this to my saved trials
Charlotte, North Carolina 28203
?
mi
from
Charlotte, NC
Click here to add this to my saved trials
Charlottesville, Virginia 22903
(434) 924-0311
University of Virginia The University of Virginia is distinctive among institutions of higher education. Founded...
?
mi
from
Charlottesville, VA
Click here to add this to my saved trials
Chicago, Illinois 60637
?
mi
from
Chicago, IL
Click here to add this to my saved trials
2600 Clifton Ave
Cincinnati, Ohio 45267
(513) 556-6000
University of Cincinnati The University of Cincinnati offers students a balance of educational excellence and...
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
Columbia, Maryland 21044
?
mi
from
Columbia, MD
Click here to add this to my saved trials
Columbia, Missouri 65201
?
mi
from
Columbia, MO
Click here to add this to my saved trials
Columbus, Ohio 43212
?
mi
from
Columbus, OH
Click here to add this to my saved trials
?
mi
from
Dallas, TX
Click here to add this to my saved trials
?
mi
from
Dallas, TX
Click here to add this to my saved trials
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Denton, Texas 76210
?
mi
from
Denton, TX
Click here to add this to my saved trials
Denver, Colorado 80218
?
mi
from
Denver, CO
Click here to add this to my saved trials
Easley, South Carolina 29640
?
mi
from
Easley, SC
Click here to add this to my saved trials
Fargo, North Dakota 58122
?
mi
from
Fargo, ND
Click here to add this to my saved trials
Flagstaff, Arizona 86002
?
mi
from
Flagstaff, AZ
Click here to add this to my saved trials
Fort Worth, Texas 76104
?
mi
from
Fort Worth, TX
Click here to add this to my saved trials
Green Bay, Wisconsin 54313
?
mi
from
Green Bay, WI
Click here to add this to my saved trials
Houston, Texas 77024
?
mi
from
Houston, TX
Click here to add this to my saved trials
Indianapolis, Indiana 46202
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
4500 San Pablo Rd S
Jacksonville, Florida 32224
(904) 953-2000
Mayo Clinic Florida Thousands of people come to Mayo Clinic in Jacksonville, Fla., annually for...
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
?
mi
from
Kingston, PA
Click here to add this to my saved trials
1 Medical Center Dr
Lebanon, New Hampshire 03756
 (603) 650-5000
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
?
mi
from
Lebanon, NH
Click here to add this to my saved trials
Lewisville, Texas 75067
?
mi
from
Lewisville, TX
Click here to add this to my saved trials
?
mi
from
Louisville, KY
Click here to add this to my saved trials
Macon, Georgia 31201
?
mi
from
Macon, GA
Click here to add this to my saved trials
Marietta, Georgia 30060
?
mi
from
Marietta, GA
Click here to add this to my saved trials
100 N Humphreys Blvd
Memphis, Tennessee 38120
(901) 683-0055
The West Clinic, PC Hello and welcome to our office. Although it is our pleasure...
?
mi
from
Memphis, TN
Click here to add this to my saved trials
Mesquite, Texas 75150
?
mi
from
Mesquite, TX
Click here to add this to my saved trials
?
mi
from
Miami, FL
Click here to add this to my saved trials
?
mi
from
Middletown, OH
Click here to add this to my saved trials
?
mi
from
Midland, TX
Click here to add this to my saved trials
Minneapolis, Minnesota 55405
?
mi
from
Minneapolis, MN
Click here to add this to my saved trials
Morristown, New Jersey 07960
?
mi
from
Morristown, NJ
Click here to add this to my saved trials
3322 West End Avenue
Nashville, Tennessee 37203
(615)329-SCRI (7274)
Sarah Cannon Research Institute Sarah Cannon Research Institute (SCRI) is a global strategic research organization...
?
mi
from
Nashville, TN
Click here to add this to my saved trials
Nashville, Tennessee 37203
?
mi
from
Nashville, TN
Click here to add this to my saved trials
New Brunswick, New Jersey 08901
?
mi
from
New Brunswick, NJ
Click here to add this to my saved trials
New York City, New York 10003
?
mi
from
New York City, NY
Click here to add this to my saved trials
New York city, New York 11363
?
mi
from
New York city, NY
Click here to add this to my saved trials
Niles, Illinois 60714
?
mi
from
Niles, IL
Click here to add this to my saved trials
5900 Lake Wright Dr
Norfolk, Virginia 23502
(757) 466-8683
Virginia Oncology Associates Virginia Oncology Associates is an oncology and hematology practice of physicians, specializing...
?
mi
from
Norfolk, VA
Click here to add this to my saved trials
Overland Park, Kansas 66210
?
mi
from
Overland Park, KS
Click here to add this to my saved trials
?
mi
from
Oxnard, CA
Click here to add this to my saved trials
Pasadena, California 91105
?
mi
from
Pasadena, CA
Click here to add this to my saved trials
Peoria, Illinois 61656
?
mi
from
Peoria, IL
Click here to add this to my saved trials
Plano, Texas 92270
?
mi
from
Plano, TX
Click here to add this to my saved trials
Plantation, Florida
?
mi
from
Plantation, FL
Click here to add this to my saved trials
?
mi
from
Port St. Lucie, FL
Click here to add this to my saved trials
Portland, Oregon 97213
?
mi
from
Portland, OR
Click here to add this to my saved trials
?
mi
from
Rancho Mirage, CA
Click here to add this to my saved trials
Rochester, Minnesota 55905
?
mi
from
Rochester, MN
Click here to add this to my saved trials
?
mi
from
Salem, VA
Click here to add this to my saved trials
100 NE Loop 410; Suite 600
San Antonio, Texas 78216
210-424-1600
Cancer Care Centers of South Texas At Cancer Care Centers of South Texas, we are...
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
San Francisco, California 94143
?
mi
from
San Francisco, CA
Click here to add this to my saved trials
Savannah, Georgia 31405
?
mi
from
Savannah, GA
Click here to add this to my saved trials
Seattle, Washington 98101
(888) 862-2737
Virginia Mason Medical Center Established in 1920, Virginia Mason began as an 80-bed hospital with...
?
mi
from
Seattle, WA
Click here to add this to my saved trials
Sherman, Texas 75090
?
mi
from
Sherman, TX
Click here to add this to my saved trials
Sioux Falls, South Dakota 57104
?
mi
from
Sioux Falls, SD
Click here to add this to my saved trials
Spokane, Washington 99218
?
mi
from
Spokane, WA
Click here to add this to my saved trials
St. Cloud, Minnesota 56303
?
mi
from
St. Cloud, MN
Click here to add this to my saved trials
St. Louis, Missouri 63131
?
mi
from
St. Louis, MO
Click here to add this to my saved trials
St. Louis, Missouri 63110
?
mi
from
St. Louis, MO
Click here to add this to my saved trials
750 East Adams Street
Syracuse, New York 13210
?
mi
from
Syracuse, NY
Click here to add this to my saved trials
Tyler, Texas 75702
?
mi
from
Tyler, TX
Click here to add this to my saved trials
Vallejo, California 94589
?
mi
from
Vallejo, CA
Click here to add this to my saved trials
Voorhees, New Jersey 08043
?
mi
from
Voorhees, NJ
Click here to add this to my saved trials
Washington, District of Columbia 20007
?
mi
from
Washington,
Click here to add this to my saved trials
Washington DC, District of Columbia 20010
?
mi
from
Washington DC,
Click here to add this to my saved trials
2811 Tieton Drive
Yakima, Washington 98902
?
mi
from
Yakima, WA
Click here to add this to my saved trials