Trial Of IW001 in Patients With Idiopathic Pulmonary Fibrosis



Status:Archived
Conditions:Pulmonary
Therapuetic Areas:Pulmonary / Respiratory Diseases
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:September 2010
End Date:September 2011

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A Phase One, Open Label, Multi-Dose Study to Evaluate the Safety, Tolerability, and Biologic Effects of Three Doses of IW001 in Patients With Idiopathic Pulmonary Fibrosis (IPF)


This is an open label, Phase One, multicenter study, designed to evaluate the safety,
tolerability, to explore the biologic effects, and to explore the clinical effects of the
following doses of IW001: 0.1mg/day, 0.5 mg/day, and 1.0 mg/day, when administered once a
day orally for 24 weeks in patients with IPF.


IW001 is a therapeutic designed to treat anti-Col (V)-mediated autoimmune diseases via oral
tolerance. With the identification of the specific antigen involved in the autoimmune
disease process in IPF, IW001 induced oral tolerance may be an effective treatment. IW001
is taken orally, introduced into the mucosal immune system at the Peyer's Patches in the
distal small intestine, where antigen-presenting cells present the antigen to regulatory T
cells (Tregs). These antigen-specific Tregs enter the blood stream and traffic to areas
where the specific antigen has generated an autoimmune response. Thus, IW001 may produce
selective suppression of immune responses against Col (V).


We found this trial at
8
sites
1500 E Medical Center Dr
Ann Arbor, Michigan 48109
(734) 936-4000
University of Michigan Health Systems The University of Michigan is home to one of the...
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Ann Arbor, MI
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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Birmingham, AL
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
University of Chicago One of the world's premier academic and research institutions, the University of...
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Chicago, IL
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111 Colchester Ave
Burlington, Vermont 05401
(802) 847-0000
Fletcher Allen Health Care As Vermont’s University Medical Center, we at Fletcher Allen are committed...
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Burlington, VT
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171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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Charleston, SC
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281 W. Lane Ave
Columbus, Ohio 43210
(614) 292-6446
Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
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Columbus, OH
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Indianapolis, Indiana 46202
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Indianapolis, IN
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530 S Jackson St
Louisville, Kentucky 40202
502-562-3226
University of Louisville Hospital As the academic hospital at the heart of the Louisville Metro...
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Louisville, KY
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