Ovarian Cancer Vaccine for Patients in Remission



Status:Archived
Conditions:Ovarian Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:February 2010
End Date:February 2013

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A Randomized, Open-Label Phase IIb Trial of Maintenance Therapy With a MUC1 Dendritic Cell Vaccine (CVac) for Epithelial Ovarian Cancer Patients in First or Second Remission


The purpose of this study is to determine the safety and efficacy of an investigational
vaccine in ovarian cancer patients in remission and to determine its ability to prevent
cancer from returning.


STUDY OBJECTIVES:

The purpose of this trial is to determine the safety and efficacy of CVac compared with
Standard of Care in ovarian cancer patients who are in remission after first or second-line
therapy.

Primary Objectives:

- To confirm the safety of administering CVac in this population.

- To determine the effects of CVac on progression-free survival (PFS).

Secondary Objectives:

- To determine overall survival (OS) for recurrent ovarian cancer patients who receive
CVac after achieving remission in the first or second-line setting.

- Evaluation of host immunologic response to CVac administration.


We found this trial at
12
sites
1959 NE Pacific St
Seattle, Washington 98195
(206) 598-3300
University of Washington Medical Center University of Washington Medical Center is one of the nation's...
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1000 Johnson Ferry Rd NE
Atlanta, Georgia 30342
(404) 851-8000
Northside Hospital Northside Hospital-Atlanta (in Sandy Springs) opened in 1970. The original facility had 250...
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Atlanta, GA
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Boynton Beach, Florida 33435
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171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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Cleveland, Ohio 44195
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Cleveland, OH
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2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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Durham, NC
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Greenbrae, California 94904
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Greenbrae, CA
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Indianapolis, Indiana 46202
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Indianapolis, IN
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100 Madison Ave
Morristown, New Jersey 7960
(973) 971-5000
Morristown Memorial Hospital Atlantic Health System – comprised of Morristown Medical Center, Overlook Medical Center,...
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Morristown, NJ
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New York, New York 10038
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New York, NY
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San Diego, California 92121
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San Diego, CA
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Stanford, CA
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