Study of the Safety and Efficacy of Apadenoson for Detection of Myocardial Perfusion Defects Using SPECT MPI



Status:Archived
Conditions:Peripheral Vascular Disease, Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:November 2009
End Date:September 2011

Use our guide to learn which trials are right for you!

The ASPECT Trial: A Phase III, Randomized, Double-Blind Crossover Trial of Apadenoson for the Detection of Myocardial Perfusion Defects Using Single-Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)


The purpose of this study is to see whether apadenoson is as effective as adenosine when
used as a pharmacological stress agent in myocardial SPECT-Imaging to detect defects in the
supply of blood to the heart muscle (myocardial perfusion defects). The study will also
look at whether apadenoson is better tolerated than adenosine when used in SPECT-MPI.


Adenosine is an effective vasodilator used in SPECT-Myocardial Perfusion Imaging
(SPECT-MPI). However, it produces transient symptoms that are poorly tolerated by most
subjects. PGxHealth has designed a multi-center, randomized crossover, double-blind study to
compare the safety and effectiveness of apadenoson to adenosine (Adenoscan®) in SPECT-MPI.
Subjects who are clinical candidates for SPECT-MPI will be enrolled to undergo two
sequential SPECT-MPI studies. The first study will use adenosine as the stress agent in
approximately 1300 subjects. Eligible subjects will then be randomized in a 1:2 assignment
ratio to receive a second SPECT-MPI using either adenosine or apadenoson as the
pharmacologic stress agent, with the goal of obtaining a total of 753 subjects who complete
both studies. The similarity of the results from the two adenosine:adenosine stress tests
will be compared to those from the adenosine:apadenosine tests to assess efficacy. The
incidence and intensity of commonly reported side effects will be compared to evaluate
improved tolerability.


We found this trial at
78
sites
Tucker, Georgia 30084
?
mi
from
Tucker, GA
Click here to add this to my saved trials
1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
655 West 8th Street
Jacksonville, Florida 32209
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
4085 University Blvd S # 1
Jacksonville, Florida 32216
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
1 Brookings Drive
St. Louis, Missouri 63110
 (314) 935-5000
Washington University Washington University creates an environment to encourage and support an ethos of wide-ranging...
?
mi
from
St. Louis, MO
Click here to add this to my saved trials
Albany, New York 12212
?
mi
from
Albany, NY
Click here to add this to my saved trials
Alexandria, Louisiana 71301
?
mi
from
Alexandria, LA
Click here to add this to my saved trials
?
mi
from
Amarillo, TX
Click here to add this to my saved trials
Auburn, Maine 04210
?
mi
from
Auburn, ME
Click here to add this to my saved trials
1120 15th Street
Augusta, Georgia 30912
(706) 721-0211
Med College of Georgia Georgia Regents University, home of the Medical College of Georgia, is...
?
mi
from
Augusta, GA
Click here to add this to my saved trials
Bend, Oregon 97701
?
mi
from
Bend, OR
Click here to add this to my saved trials
?
mi
from
Buffalo, NY
Click here to add this to my saved trials
Camp Hill, Pennsylvania 17011
?
mi
from
Camp Hill, PA
Click here to add this to my saved trials
171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
?
mi
from
Charleston, SC
Click here to add this to my saved trials
281 W. Lane Ave
Columbus, Ohio 43210
(614) 292-6446
Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
?
mi
from
Columbus, OH
Click here to add this to my saved trials
?
mi
from
Columbus, OH
Click here to add this to my saved trials
Cumming, Georgia 30041
?
mi
from
Cumming, GA
Click here to add this to my saved trials
Daytona Beach, Florida 32114
?
mi
from
Daytona Beach, FL
Click here to add this to my saved trials
Gainesville, Florida 32605
?
mi
from
Gainesville, FL
Click here to add this to my saved trials
Hartwell, Georgia 30643
?
mi
from
Hartwell, GA
Click here to add this to my saved trials
Honolulu, Hawaii 96813
?
mi
from
Honolulu, HI
Click here to add this to my saved trials
Houston, Texas 77098
?
mi
from
Houston, TX
Click here to add this to my saved trials
Indianapolis, Indiana 46260
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
Jacksonville, Florida 32258
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
Jacksonville, Florida 32207
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
Jacksonville, Florida 32216
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
Johnson City, Tennessee 37604
?
mi
from
Johnson City, TN
Click here to add this to my saved trials
Johnson City, Tennessee 37604
?
mi
from
Johnson City, TN
Click here to add this to my saved trials
?
mi
from
Kansas City, MO
Click here to add this to my saved trials
Kansas City, Missouri 64132
?
mi
from
Kansas City, MO
Click here to add this to my saved trials
Kingston, New York 12401
?
mi
from
Kingston, NY
Click here to add this to my saved trials
La Mesa, California 91942
?
mi
from
La Mesa, CA
Click here to add this to my saved trials
Little Rock, Arkansas 72204
?
mi
from
Little Rock, AR
Click here to add this to my saved trials
Lorain, Ohio 44053
?
mi
from
Lorain, OH
Click here to add this to my saved trials
Louisville, Kentucky 40205
?
mi
from
Louisville, KY
Click here to add this to my saved trials
Madison, Wisconsin 53715
?
mi
from
Madison, WI
Click here to add this to my saved trials
?
mi
from
Manhasset, NY
Click here to add this to my saved trials
Massapequa, New York 11758
?
mi
from
Massapequa, NY
Click here to add this to my saved trials
McKinney, Texas 75069
?
mi
from
McKinney, TX
Click here to add this to my saved trials
Melbourne, Florida 32901
?
mi
from
Melbourne, FL
Click here to add this to my saved trials
?
mi
from
Miami, FL
Click here to add this to my saved trials
Mission Viejo, California 92691
?
mi
from
Mission Viejo, CA
Click here to add this to my saved trials
?
mi
from
Missoula, MT
Click here to add this to my saved trials
?
mi
from
Munster, IN
Click here to add this to my saved trials
?
mi
from
Naples, FL
Click here to add this to my saved trials
New Britain, Connecticut 06052
?
mi
from
New Britain, CT
Click here to add this to my saved trials
Newark, Delaware 19713
?
mi
from
Newark, DE
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73120
?
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
Overland Park, Kansas 66209
?
mi
from
Overland Park, KS
Click here to add this to my saved trials
Petoskey, Michigan 49770
?
mi
from
Petoskey, MI
Click here to add this to my saved trials
2900 W Queen Ln
Philadelphia, Pennsylvania 19129
(215) 991-8100
Drexel University College of Medicine Drexel University College of Medicine represents the consolidation of two...
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
3401 N Broad St
Philadelphia, Pennsylvania
(215) 707-2000
Temple University Hospital On January 18, 1892 a three-story house at 3403 North Broad Street...
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Phoenix, Arizona 85020
?
mi
from
Phoenix, AZ
Click here to add this to my saved trials
Phoenix, Arizona 85006
?
mi
from
Phoenix, AZ
Click here to add this to my saved trials
200 Lothrop St
Pittsburgh, Pennsylvania 15213
University of Pittsburgh Medical Center UPMC is one of the leading nonprofit health systems in...
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
Plano, Texas 75024
?
mi
from
Plano, TX
Click here to add this to my saved trials
Roanoke, Virginia 24014
?
mi
from
Roanoke, VA
Click here to add this to my saved trials
Roseville, California 95661
?
mi
from
Roseville, CA
Click here to add this to my saved trials
Sacramento, California 95825
?
mi
from
Sacramento, CA
Click here to add this to my saved trials
Santa Rosa, California 95405
?
mi
from
Santa Rosa, CA
Click here to add this to my saved trials
Scarborough, Maine 04074
?
mi
from
Scarborough, ME
Click here to add this to my saved trials
Seattle, Washington 98195
(206) 543-2100
University of Washington Founded in 1861 by a private gift of 10 acres in what...
?
mi
from
Seattle, WA
Click here to add this to my saved trials
Sellersville, Pennsylvania 18960
?
mi
from
Sellersville, PA
Click here to add this to my saved trials
Simpsonville, South Carolina 29681
?
mi
from
Simpsonville, SC
Click here to add this to my saved trials
South Portland, Maine 04106
?
mi
from
South Portland, ME
Click here to add this to my saved trials
Spokane, Washington 99204
?
mi
from
Spokane, WA
Click here to add this to my saved trials
Spokane, Washington 99204
?
mi
from
Spokane, WA
Click here to add this to my saved trials
?
mi
from
St Louis, MO
Click here to add this to my saved trials
Towson, Maryland 21014
?
mi
from
Towson, MD
Click here to add this to my saved trials
?
mi
from
Tupelo, MS
Click here to add this to my saved trials
?
mi
from
Valparaiso, IN
Click here to add this to my saved trials
Walnut Creek, California 94598
?
mi
from
Walnut Creek, CA
Click here to add this to my saved trials
West Bloomfield, Michigan 48322
?
mi
from
West Bloomfield, MI
Click here to add this to my saved trials
West Des Moines, Iowa 50266
?
mi
from
West Des Moines, IA
Click here to add this to my saved trials
Westlake, Ohio 44145
?
mi
from
Westlake, OH
Click here to add this to my saved trials
Wichita, Kansas 67206
?
mi
from
Wichita, KS
Click here to add this to my saved trials
Winfield, Illinois 60190
?
mi
from
Winfield, IL
Click here to add this to my saved trials
Wyomissing, Pennsylvania 19610
?
mi
from
Wyomissing, PA
Click here to add this to my saved trials