Investigation of the Biomarker Copeptin in Patients With Acute Myocardial Infarction



Status:Archived
Conditions:Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:August 2009
End Date:March 2011

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Copeptin Helps in the Early Detection Of Patients With Acute Myocardial


While troponin is not detectable until several hours after an Acute Myocardial Infarction
(AMI), copeptin is expected to be elevated very early after an AMI. A combination of both
markers for the diagnosis of AMI early after the event is therefore expected to be
advantageous.


In patients with symptoms suggestive of acute coronary syndrome (ACS) such as chest pain or
pressure, shortness of breath, diaphoresis, and nausea, detection of a rise and/or fall of
troponin with at least one value above the 99th percentile of the upper reference limit is
essential to the diagnosis of acute myocardial infarction (AMI). However, current troponin
testing has limitations, including antibody specificity, assay imprecision, lack of
standardization and a relatively late increase in the circulating troponin level after the
onset of ischemia. Studies have shown a low diagnostic sensitivity of troponins when
measured early (<6 hours) after symptom onset. Although there are some more sensitive
troponin assays with a coefficient of variation (CV)10% at the 99th percentile of a normal
reference population, most troponin assays have an imprecision CV of around 20% at the 99th
percentile of the reference population. The early insensitivity of troponin results in an
unmet need in the clinical evaluation of patients presenting with suspected ACS and AMI.

Copeptin may improve early AMI diagnostic sensitivity because of a number of unique
characteristics.

- Copeptin levels are elevated at presentation in patients with AMI compared to patients
with other presentations.

- Copeptin levels are elevated in patients with AMI even when troponin levels were not
elevated at the time of initial presentation.

- Thus, a combination of troponin and copeptin levels at presentation may result in a
more accurate diagnosis of acute AMI than troponin alone.

- Copeptin levels drop 1 day after an AMI.


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2799 W Grand Blvd
Detroit, Michigan 48202
(313) 916-2600
Henry Ford Hospital Founded in 1915 by auto pioneer Henry Ford and now one of...
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621 West Lombard Street
Baltimore, Maryland 21201
(410) 706-7101
University of Maryland, Baltimore Welcome to the University of Maryland, Baltimore (UMB) founded in 1807...
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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3400 Spruce St
Philadelphia, Pennsylvania 19104
 (215) 662-4000
Hospital of the University of Pennsylvania The Hospital of the University of Pennsylvania (HUP) is...
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Cleveland, Ohio 44195
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Kansas City, Kansas
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701 Park Ave
Minneapolis, Minnesota 55415
(612) 873-3000
Hennepin County Medical Center - Minneapolis Hennepin Healthcare System, Inc. operates Hennepin County Medical Center...
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1250 E. Marshall St.
Richmond, Virginia 23298
(804) 828-9000
Virginia Commonwealth University Medical Center The Virginia Commonwealth University Health System is an urban, comprehensive...
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1001 Potrero Ave
San Francisco, California 94110
(415) 206-8000
San Francisco General Hospital San Francisco General Hospital and Trauma Center (SFGH) is an essential...
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San Francisco, California 94115
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300 Pasteur Dr
Stanford, California 94305
(650) 723-4000
Stanford university Hospital and Clinics Throughout our history, we have pioneered medical advances that save...
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