Study of Cicletanine for Pulmonary Arterial Hypertension (PAH)



Status:Archived
Conditions:High Blood Pressure (Hypertension)
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:January 2009
End Date:December 2015

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A Phase 2, Randomized, Double-blind, Placebo-controlled, Multicenter, Dose-ranging Study of Cicletanine in Subjects With Pulmonary Arterial Hypertension


This Phase 2, randomized, double-blind, placebo-controlled, multicenter, dose-ranging study
will compare the efficacy, safety, and tolerability of cicletanine HCl to placebo in
subjects with PAH. Study drug will be administered alone, or on the background of stable PAH
therapy. The study will consist of 3 periods: a screening period, a 12-week
placebo-controlled treatment period, and a long-term, blinded extension period.


The primary objective of this study is to compare the change in exercise capacity following
treatment with cicletanine HCl or placebo in subjects with PAH.

The secondary objectives of this study are:

1. To compare the change in other clinical measures of PAH following treatment with
cicletanine HCl or placebo in subjects with PAH

2. To compare the safety and tolerability of cicletanine HCl to placebo in subjects with
PAH Additionally, the long-term safety, tolerability, and efficacy of cicletanine HCl
treatment will be evaluated.


We found this trial at
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3400 Spruce St
Philadelphia, Pennsylvania 19104
 (215) 662-4000
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201 Dowman Dr
Atlanta, Georgia 30303
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621 West Lombard Street
Baltimore, Maryland 21201
(410) 706-7101
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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300 Longwood Avenue
Boston, Massachusetts 02115
617-355-6000
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1 Boston Medical Center Pl
Boston, Massachusetts 02118
617.638.8000
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330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
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5303 Harry Hines Boulevard
Dallas, Texas 75390
(214) 648-3111
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Denver, Colorado 80218
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Gainesville, Florida 32611
(352) 392-3261
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101 Jessup Hall
Iowa City, Iowa 52242
(319) 335-3500
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New York, New York 10021
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1 Gustave L Levy Pl # 271
New York, New York 10029
 (212) 241-6500
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593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
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1 Brookings Drive
St. Louis, Missouri 63110
 (314) 935-5000
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Weston, Florida 33331
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2950 Cleveland Clinic Blvd.
Weston, Florida 33331
866.293.7866
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1120 15th Street
Augusta, Georgia 30912
(706) 721-0211
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Boston, Massachusetts 02111
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Boulder, Colorado 80309
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101 Manning Dr
Chapel Hill, North Carolina 27599
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Charlottesville, Virginia 22903
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Cincinnati, Ohio 45219
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10900 Euclid Ave
Cleveland, Ohio 44106
216-368-2000
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263 Farmington Ave
Farmington, Connecticut 06030
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1 Baylor Plaza
Houston, Texas 77030
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757 Westwood Plaza
Los Angeles, California 90024
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307 N University Blvd
Mobile, Alabama 36688
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5121 S Cottonwood St
Murray, Utah 84157
(801) 507-7000
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New Orleans, Louisiana 70112
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722 W 168th St
New York, New York 10032
(212) 305-2500
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Pittsburgh, Pennsylvania 15212
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200 Lothrop St
Pittsburgh, Pennsylvania 15213
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200 First Street SW
Rochester, Minnesota 55905
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601 Elmwood Ave
Rochester, New York 14642
(585) 275-2100
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