Study Evaluating The Efficacy And Safety Of Bapineuzumab In Alzheimer Disease Patients



Status:Terminated
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - 89
Updated:4/21/2016
Start Date:June 2008
End Date:August 2013

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Efficacy And Safety Trial Of Bapineuzumab (Aab-001, Eln115727) In Subjects With Mild to Moderate Alzheimer Disease Who Are Apolipoprotein E 4 Non-carriers

This is a study to evaluate the efficacy and safety of multiple doses of bapineuzumab in
patients with mild to moderate Alzheimer Disease. Patients will receive either bapineuzumab
or placebo. Each patient's participation will last approximately 1.5 years.


Inclusion Criteria:

- Diagnosis of probable Alzheimer Disease (AD), with Mini Mental State Examination
(MMSE) score of 16-26, and brain magnetic resonance imaging (MRI) consistent with the
diagnosis of AD

- Concurrent use of cholinesterase inhibitor or memantine allowed, if stable

- Caregiver will participate and be able to attend clinic visits with patient

Exclusion Criteria:

- Significant neurological disease other than AD

- Major psychiatric disorder

- Contraindication to undergo brain MRI [e.g., pacemaker, cerebrospinal fluid (CSF)
shunt, or foreign metal objects in the body]

- Women of childbearing potential
We found this trial at
161
sites
NeuroStudies.net
Decatur, Georgia 30033
2182
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Decatur, GA
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Comprehensive Clinical Research
175 Cross Keys Rd.
Berlin, New Jersey 08009
856-753-7335
2389
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Berlin, NJ
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University of Alabama at Birmingham
1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
2072
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Birmingham, AL
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Massachusetts General Hospital
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
2485
mi
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Boston, MA
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Brigham and Women's Hosp
75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
2485
mi
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Boston, MA
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Alpine Clinical Research Center
1000 Alpine
Boulder, Colorado 80304
303-443-7229
996
mi
from 98109
Boulder, CO
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University of North Texas Health Science Center
3500 Camp Bowie Boulevard
Fort Worth, Texas 76107
1659
mi
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Fort Worth, TX
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MD Clinical
911 E. Hallandale Beach Blvd
Hallandale Beach, Florida 33009
954-455-5757
2723
mi
from 98109
Hallandale Beach, FL
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Renstar Medical Research
104 SE 1st Avenue
Ocala, Florida 34471
352-629-5800
2483
mi
from 98109
Ocala, FL
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Compass Research LLC
100 West Gore St # 202
Orlando, Florida 32806
(407) 426-9299
Compass Research LLC Compass Research is a clinical research company dedicated to testing new medications...
2547
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Orlando, FL
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Hospital of the University of Pennsylvania
3400 Spruce St
Philadelphia, Pennsylvania 19104
 (215) 662-4000
Hospital of the University of Pennsylvania The Hospital of the University of Pennsylvania (HUP) is...
2371
mi
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Philadelphia, PA
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Innovative Clinical Trials
5430 Fredericksburg Road
San Antonio, Texas 78229
210-377-2873
1780
mi
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San Antonio, TX
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Integra Clinical Research
3603 Paesanos Parkway
San Antonio, Texas 78231
210-614-4884
1775
mi
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San Antonio, TX
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Stedman Clinical Trials
3212 Cove Bend Drive
Tampa, Florida 33613
2522
mi
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Tampa, FL
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Neurology & Neuroscience Center of Ohio
1000 Regency Court
Toledo, Ohio 43623
419-841-7369
1923
mi
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Toledo, OH
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Chase Medical Research, LLC
500 Chase Parkway
Waterbury, Connecticut 06708
203-419-4420
2418
mi
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Waterbury, CT
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Abington Memorial Hospital
1200 Old York Road
Abington, Pennsylvania 19001
(215) 481–2000
Abington Memorial Hospital Abington Memorial Hospital (AMH) is a 665-bed, regional referral center and teaching...
2369
mi
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Abington, PA
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Abington Neurological Associates
Abington, Pennsylvania 19001
2370
mi
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Abington, PA
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University of Michigan Health System
1500 E Medical Center Dr
Ann Arbor, Michigan 48109
(734) 936-4000
University of Michigan Health System The University of Michigan is home to one of the...
1903
mi
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Ann Arbor, MI
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University of Michigan Hospital
Ann Arbor, Michigan 48109
1905
mi
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Ann Arbor, MI
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Clinical Study Center of Asheville, LLC
Asheville, North Carolina 28803
2187
mi
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Asheville, NC
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NeuroTrials Research, Incorporated
Atlanta, Georgia 30342
2174
mi
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Atlanta, GA
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JEM Research Institute
Atlantis, Florida 33462
2696
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Atlantis, FL
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Medical Specialists of the Palm Beaches
Atlantis, Florida 33462
2696
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Atlantis, FL
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Austin Infusion Centers
Austin, Texas 78756
1768
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Austin, TX
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Senior Adults Specialty Research
Austin, Texas 78757
1770
mi
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Austin, TX
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Southwestern Vermont Healthcare
Bennington, Vermont 05201
2372
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Bennington, VT
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The Memory Clinic
Bennington, Vermont 05201
2372
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Bennington, VT
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Foers Medical Arts Pharmacy
Bethesda, Maryland 20814
2316
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Bethesda, MD
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Bringham and Women's Hospital
Boston, Massachusetts 02115
2485
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General Clinical Research Center
Boston, Massachusetts 02118
2485
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Boston, MA
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Boston University
One Silber Way
Boston, Massachusetts 02215
(617) 353-2000
Boston University Boston University is no small operation . With over 33,000 undergraduate and graduate...
2485
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Boston, MA
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IDS Pharmacy
Boston, Massachusetts 02118
2485
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Boston, MA
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Pacific Medical Centers
Bothell, Washington 98021
12
mi
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Bothell, WA
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Associated Neurologists, PC
Boulder, Colorado 80304
997
mi
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Boulder, CO
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Bradenton Research Center, Incorporated
Bradenton, Florida 34205
2543
mi
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Bradenton, FL
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Northeast Radiology
Brewster, New York 10509
2398
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Brewster, NY
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Cemic University Hospital
Buenos Aires,
6918
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from 98109
Buenos Aires,
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Medical University of South Carolina Hospitals and Clinics
Charleston, South Carolina 29425
2423
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Charleston, SC
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Medical University of South Carolina Investigational Drug Service
Charleston, South Carolina 29425
2422
mi
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Charleston, SC
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Alzheimer's Memory Center
Charlotte, North Carolina 28211
2281
mi
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Charlotte, NC
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University of Virginia Neurology
Charlottesville, Virginia 22903
2285
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Charlottesville, VA
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University Of Virginia General Clinical Research Center
Charlottesville, Virginia 22908
2284
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Charlottesville, VA
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University of Viriginia Investigational Pharmacy
Charlottesville, Virginia 22908
2284
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Charlottesville, VA
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Columbus Diagnostic Center (MRI)
Columbus, Georgia 31901
2207
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Columbus, GA
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Medical Research and Health Education Foundation, Incorporated
Columbus, Georgia 31909
2206
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Columbus, GA
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Ohio State University Imaging at Martha Morehouse
Columbus, Ohio 43210
2006
mi
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Columbus, OH
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The Ohio State University Hospitals Clinic
Columbus, Ohio 43210
2006
mi
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Columbus, OH
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Ohio State University Medical Center
Columbus, Ohio 43210
2007
mi
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Columbus, OH
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Ohio State University
281 W. Lane Ave
Columbus, Ohio 43210
(614) 292-6446
Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
2006
mi
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Columbus, OH
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Neurology Clinic, PC
Cordova, Tennessee 38018
1875
mi
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Cordova, TN
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ATP Clinical Research, Incorporated
Costa Mesa, California 92626
992
mi
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Costa Mesa, CA
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Texas Neurology, PA
Dallas, Texas 75214
1680
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Dallas, TX
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Associated Neurologists, P.C.
Danbury, Connecticut 06810
2405
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Danbury, CT
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Dekalb Neurology Associates, LLC/NeuroStudies.net, LLC
Decatur, Georgia 30033
2181
mi
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Decatur, GA
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North Broward Medical Center
Deerfield Beach, Florida 33064
2711
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Deerfield Beach, FL
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Brain Matters Research
Delray Beach, Florida 33445
2702
mi
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Delray Beach, FL
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Mile High Research Center
Denver, Colorado 80218
1021
mi
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Denver, CO
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Michigan State University
East Lansing, Michigan 48824
1855
mi
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East Lansing, MI
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Rhode Island Mood & Memory Research Institute
East Providence, Rhode Island 02914
2487
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East Providence, RI
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Memory Enhancement Center of America, Inc.
Eatontown, New Jersey 07724
2412
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Eatontown, NJ
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Alexian Brothers Medical Center
Elk Grove Village, Illinois 60007
1713
mi
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Elk Grove Village, IL
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Alexian Brothers Neurosciences Institute
Elk Grove Village, Illinois 60007
1712
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Elk Grove Village, IL
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Elkhart Clinic, LLC
303 S Nappanee St
Elkhart, Indiana 46514
(574) 296-3200
Elkhart Clinic, LLC Informed participation in the management of your health care maximizes your Elkhart...
1815
mi
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Elkhart, IN
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Pharmacology Research Institute
Encino, California 91316
951
mi
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Encino, CA
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Associated Neurologists of Southern Connecticut, PC
Fairfield, Connecticut 06824
2423
mi
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Fairfield, CT
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Marty's Pharmacy
Flowood, Mississippi 39232
1985
mi
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Flowood, MS
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Precise Research Centers
Flowood, Mississippi 39232
1974
mi
from 98109
Flowood, MS
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Neurologic Consultants, PA
Fort Lauderdale, Florida 33308
2715
mi
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Fort Lauderdale, FL
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Margolin Brain Institute
Fresno, California 93720
755
mi
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Fresno, CA
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Dedicated Clinical Research
Goodyear, Arizona 85395
1106
mi
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Goodyear, AZ
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Advanced Neurology Specialists
Great Falls, Montana 59405
515
mi
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Great Falls, MT
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Spectrum Home Solutions
Great Falls, Montana 59405
515
mi
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Great Falls, MT
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Bendheim Cancer Center
Greenwich, Connecticut 06830
2409
mi
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Greenwich, CT
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Center for Healthy Aging
Greenwich, Connecticut 06830
2409
mi
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Greenwich, CT
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Radiant Research, Incorporated
Greer, South Carolina 29651
2229
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Greer, SC
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Hattiesburg Clinic
Hattiesburg, Mississippi 39401
2070
mi
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Hattiesburg, MS
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ActivMed Practices and Research
Haverhill, Massachusetts 01830
2471
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Haverhill, MA
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Clinical Trials of America, Incorporated
Hickory, North Carolina 28601
2238
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The Compounding Pharmacy
Hickory, North Carolina 28602
2238
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Hickory, NC
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The Clinical Trial Center, LLC
Jenkintown, Pennsylvania 19046
2371
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Jenkintown, PA
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The Center for Pharmaceutical Research, P.C.
Kansas City, Missouri 64114
1507
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Infusion Care Pharmacey
Laguna Hills, California 92653
999
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Laguna Hills, CA
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Senior Clinical Trials, Incorporated
Laguna Hills, California 92653
999
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Laguna Hills, CA
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Lake Charles Clinical Trials LLC
Lake Charles, Louisiana 70601
1954
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Lake Charles, LA
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Michigan State University
409 West Circle Drive
Lansing, Michigan 48910
1855
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Lansing, MI
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Neurostudies.net
Lawerenceville, Georgia 30045
2192
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Lawerenceville, GA
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Neurostudies.net
Lawrenceville, Georgia 30046
2188
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Lawrenceville, GA
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Clinical Trials, Inc.
Little Rock, Arkansas 72205
1779
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Neurological Care of Central New York
Liverpool, New York 13088
2226
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Liverpool, NY
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Faculty Physicians and Surgeons of Loma Linda University School of Medicine
Loma Linda, California 92354
974
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Loma Linda, CA
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Loma Linda University Medical Center
11234 Anderson St
Loma Linda, California 92354
(909) 558-4000
Loma Linda University Medical Center An outgrowth of the original Sanitarium on the hill in...
974
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Loma Linda, CA
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Collaborative Neuroscience Network, Inc.
Long Beach, California 90806
979
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Long Beach, CA
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Pharmacology Research Institute
Los Alamitos, California 90720
981
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Los Alamitos, CA
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Alzheimer's Research Corporation
Manchester, New Jersey 08759
2409
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Manchester, NJ
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Psychology Associates
Mishawaka, Indiana 46545
1808
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Mishawaka, IN
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The Institute for Neurodegenerative Disorders
New Haven, Connecticut 06510
2432
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New Haven, CT
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Yale University School of Medicine
333 Cedar St
New Haven, Connecticut 06504
(203) 432-4771
Yale University School of Medicine Founded in 1810, the Yale School of Medicine is a...
2432
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Yale-New Haven Hospital
20 York St, N20 York St,
New Haven, Connecticut 06520
(203) 688-4242
Yale-New Haven Hospital Relying on the skill and expertise of more than 4,500 university and...
2432
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Norman S. Werdiger, MD
New Haven, Connecticut 06519
2432
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New Haven, CT
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Institutional Review Board / Ethics Committee
New Haven, Connecticut 06520
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New Haven, CT
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