Correlative Biomarker Study in Patients With Myeloproliferative Disorders



Status:Completed
Conditions:Cancer, Other Indications, Hematology
Therapuetic Areas:Hematology, Oncology, Other
Healthy:No
Age Range:18 - Any
Updated:12/15/2018
Start Date:April 2007
End Date:July 20, 2018

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Correlative Biomarker Study for MPD-RC Treatment Studies in the Philadelphia Chromosome Negative MPD

Researchers will use abnormal blood and/or bone marrow cells, or materials derived from these
abnormal cells, like DNA, RNA, protein or plasma, in laboratory studies. Toenail clippings
will provide normal material like DNA for comparison with the abnormal material derived from
the blood and/or bone marrow. The results of these studies will be correlated with subjects'
disease symptoms and response to their experimental treatment. The MPD-RC researchers are
interested in studying molecules from the blood and bone marrow, the exact molecules changing
over time with the investigators choosing only the most promising for investigation.

The investigators are attempting to better understand the causes of MPD and to develop
improved methods for the diagnosis and treatment of these diseases. These syndromes carry a
high risk of developing leukemia. It is important to continue to learn more about these blood
cancers and to learn more about the effectiveness and potential side effects of various
treatments. It is believed that further basic knowledge about these cancer cells as well as
the effects of treatment will lead to the improvement of current therapies and the
development of entirely new treatments for these diseases. The MPD-RC is hoping to determine
if a number of laboratory tests (biomarkers) will allow for the prediction of response in
future patients to the treatment they would receive.


Inclusion Criteria:

- Patients are to be registered to this study if they meet the eligibility criteria for
one of the MPD-RC treatment protocols linked to this study.

- Patients diagnosed with the following Myeloproliferative disorders including:
polycythemia vera (PV), idiopathic myelofibrosis (IM), and essential thrombocythemia
(ET) who are participating in treatment protocols of the MPD-RC are eligible.

- Patients must have signed an informed consent to participate in a Myeloproliferative
Disorders Research Consortium (MPD-RC) treatment study to which this protocol is a
companion study. The subject must also have signed a consent to participate in this
mandatory companion study.

Exclusion Criteria:

See inclusion criteria.
We found this trial at
16
sites
Baltimore, Maryland 20742
(301) 405-1000
Principal Investigator: Maria Baer, MD
Phone: 410-328-8708
University of Maryland As a globally-connected university offering a world-class education, the University of Maryland...
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201 Presidents Circle
Salt Lake City, Utah 84108
801) 581-7200
Principal Investigator: Josef Prachal, MD
University of Utah Research is a major component in the life of the U benefiting...
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Atlanta, Georgia 30322
Principal Investigator: Elliot Winton, MD
Phone: 404-778-5871
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Atlanta, GA
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2035 W Taylor St
Chicago, Illinois
(312) 996-4350
Principal Investigator: Damiano Rondelli, MD
University of Illinois at Chicago A major research university in the heart of one of...
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Chicago, IL
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281 W. Lane Ave
Columbus, Ohio 43210
(614) 292-6446
Principal Investigator: Rebecca Klisovic, MD
Phone: 614-293-4696
Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
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2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Principal Investigator: Murat Arcasoy, MD
Phone: 919-668-6309
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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Hazleton, Pennsylvania 18201
Principal Investigator: Harsh Gandhi, MD
Phone: 570-459-2901
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Hazleton, PA
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1428 Madison Ave
New York, New York 10029
(212) 241-6500
Principal Investigator: John Mascarenhas, MD
Phone: 212-241-3417
Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai is...
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New York, New York 10021
Principal Investigator: Tsiporah Shore, MD
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New York, New York 10021
Principal Investigator: Rona S Weinberg, PhD
Phone: 212-570-3412
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Palo Alto, California 94301
Principal Investigator: David Liebowitz, MD
Phone: 650-853-2905
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3451 Walnut St
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Principal Investigator: Elizabeth Hexner, MD
Phone: 215-662-4137
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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Scottsdale, Arizona 85259
Principal Investigator: Ruben Mesa, MD
Phone: 480-301-8335
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Toronto, Ontario
Principal Investigator: Vikas Gupta, MD
Phone: 416-946-6546
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3700 O St NW
Washington, District of Columbia 20057
(202) 687-0100
Georgetown University Georgetown University is one of the world's leading academic and research institutions, offering...
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1 Medical Center Blvd
Winston-Salem, North Carolina 27103
(336) 716-2011
Principal Investigator: Dmitry Berenzon, MD
Phone: 336-716-5847
Wake Forest University Baptist Medical Center Welcome to Wake Forest Baptist Medical Center, a fully...
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Winston-Salem, NC
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