e-Cigarette - DNA Adducts



Status:Recruiting
Conditions:Smoking Cessation, Smoking Cessation
Therapuetic Areas:Pulmonary / Respiratory Diseases
Healthy:No
Age Range:18 - Any
Updated:3/22/2019
Start Date:July 11, 2017
End Date:August 1, 2022
Contact:Drake I Burri
Email:burri078@umn.edu
Phone:612-626-5107

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e-Cigarettes: Formaldehyde DNA Adducts, Oxidative Damage, and Potential Toxicity and Carcinogenesis

This study will examine the level of toxicity of e-cigarette use compared to smokers and
nonsmokers including inflammation markers, toxicant and carcinogen exposure. Additionally,
the study will look at the effect of varying voltage levels for e-cigarette users.

In this observational study, e-cigarette users, smokers, and non-users of e-cigarette or
tobacco products (up to 134 per group) will be recruited from the Minneapolis-St. Paul area.
This research will be conducted at the Tobacco Research Programs at the University of
Minnesota. Subjects are screened for eligibility over the phone. If eligible after the phone
screen, participants will be invited to attend orientation screening visit in the clinic
where consent will be obtained and subjects will complete forms about their tobacco and
e-cigarette use and medical history. Subjects who eligible will be asked to return for six
visits over the course of six months.

At these appointments, subjects will provide biological specimen samples (buccal cells, urine
and blood). Saliva will be collected before and after a smoking or vaping session. Non-users
will only have 1 saliva collection.

Subjects will be asked for information pertaining to and e-cigarette and tobacco use and
overall health.

Inclusion Criteria:

- Good physical health with no unstable medical conditions; Able to provide written
informed consent; Stable and good mental health;

Meet criteria for 1 of three groups:

1. Regular smokers confirmed by CO;

2. E-cigarette users (exclusive e-cigarette use for 3 months); Non-Tobacco Users

3. Non-smokers

Exclusion Criteria:

- Unstable medical condition Not willing to attend visits
We found this trial at
1
site
Minneapolis, Minnesota 55455
(612) 625-5000
Principal Investigator: Stephen Hecht, Phd
Phone: 612-626-5107
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
?
mi
from
Minneapolis, MN
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