PF-06651600 for the Treatment of Alopecia Areata



Status:Recruiting
Conditions:Dermatology, Dermatology, Hair Loss
Therapuetic Areas:Dermatology / Plastic Surgery
Healthy:No
Age Range:12 - Any
Updated:3/28/2019
Start Date:December 3, 2018
End Date:March 28, 2021
Contact:Pfizer CT.gov Call Center
Email:ClinicalTrials.gov_Inquiries@pfizer.com
Phone:1-800-718-1021

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A PHASE 2B/3 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-RANGING STUDY TO INVESTIGATE THE EFFICACY AND SAFETY OF PF-06651600 IN ADULT AND ADOLESCENT ALOPECIA AREATA (AA) SUBJECTS WITH 50% OR GREATER SCALP HAIR LOSS

This is a global Phase 2b/3 study to evaluate the safety and effectiveness of an
investigational study drug (called PF-06651600) in adults and adolescents (12 years and
older) who have 50% or greater scalp hair loss. The study is placebo-controlled, meaning that
some patients entering the study will not receive active study drug but will receive tablets
with no active ingredients (a placebo). This is a dose-ranging study, investigating 5
different dosing regimens. It will be double-blinded, meaning that the sponsor, the study
doctors, the staff, and the patients will not know whether a patient is on active study drug
(or the dose) or placebo.


Inclusion Criteria:

- Clinical diagnosis of alopecia areata with no other cause of hair loss

- ≥50% hair loss of the scalp, including alopecia totalis and alopecia universalis,
without evidence of terminal hair regrowth within 6 months

- Current episode of hair loss ≤10 years

Exclusion Criteria:

- Other types of alopecia or other diseases that can cause hair loss

- Other scalp diseases that could interfere with assessment of hair loss/regrowth

- Subjects with shaved heads must not enter the study until hair has grown back & is
considered stable by the investigator

- Any previous use of any Janus kinase (JAK) inhibitor
We found this trial at
15
sites
Orange Park, Florida 32073
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Orange Park, FL
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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Boston, MA
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6565 S. Yale Ave.
Tulsa, Oklahoma 74136
918-392-4550
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Tulsa, OK
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Boise, ID
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9897 Hagen Ranch Road
Boynton Beach, Florida 33472
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Boynton Beach, FL
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Indianapolis, Indiana 46256
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Indianapolis, IN
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Irvine, CA
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Kogarah, New South Wales 2217
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Kogarah,
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Murrieta, California 92562
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Murrieta, CA
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Omaha, Nebraska 68144
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Omaha, NE
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Santa Ana, California 92701
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Santa Ana, CA
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1821 Wilshire Boulevard
Santa Monica, California 90403
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Santa Monica, CA
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Skokie, Illinois 60076
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Skokie, IL
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Tampa, Florida 33624
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Tampa, FL
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Verona, New Jersey 07044
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Verona, NJ
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