Oral Factor XIa Inhibitor for the Prevention of New Ischemic Stroke in Patients Receiving Aspirin and Clopidogrel Following Acute Ischemic Stroke or Transient Ischemic Attack (TIA)



Status:Recruiting
Conditions:Peripheral Vascular Disease, Neurology
Therapuetic Areas:Cardiology / Vascular Diseases, Neurology
Healthy:No
Age Range:40 - Any
Updated:4/5/2019
Start Date:November 30, 2018
End Date:August 31, 2021
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information
Email:Clinical.Trials@bms.com
Phone:please email

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A Global, Phase 2, Randomized, Double-Blind, Placebo-Controlled, Response-Adaptive Dose-Ranging Study of BMS-986177, an Oral Factor XIa Inhibitor, for the Prevention of New Ischemic Stroke or New Covert Brain Infarction in Patients Receiving Aspirin and Clopidogrel Following Acute Ischemic Stroke or Transient Ischemic Attack (TIA)

The purpose of this clinical study is to determine whether the addition of an oral Factor XIa
Inhibitor to Aspirin and Clopidogrel is more effective than standard therapy in secondary
stroke prevention. The safety of this treatment will also be studied.


For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Male and Female ≥40 years of age

- Acute Ischemic Stroke or Transient Ischemic Attack

- Intracranial or Extracranial Atherosclerotic Plaque proximal to the affected brain
area

Exclusion Criteria:

- Predicted inability to swallow study medication

- Any condition that, in the opinion of the Investigator, contraindicates anticoagulant
therapy or would have an unacceptable risk of bleeding

- Use of thrombolytic therapy or mechanical thrombectomy for treatment of acute ischemic
stroke event

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
34
sites
Birmingham, Alabama 35294
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3400 Spruce St
Philadelphia, Pennsylvania 19104
 (215) 662-4000
Hospital of the University of Pennsylvania The Hospital of the University of Pennsylvania (HUP) is...
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Augusta, Georgia 30912
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Austin, Texas 78701
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Capital Federal, Buenos Aires
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Capital Federal,
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Chapel Hill, North Carolina 27599
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Cleveland, Ohio 44195
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Columbia, South Carolina 29201
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Dallas, Texas 75246
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Durham, North Carolina 27710
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El Paso, Texas 79902
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Erie, Pennsylvania 16505
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Gainesville, Florida 32603
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Glendale, California 91206
Phone: 818-409-8009
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Great Falls, Montana 59405
Phone: 406-455-2583
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Greensboro, North Carolina 27401
Phone: 336-516-9104
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Houston, Texas 77030
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Kansas City, Missouri 64108
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Long Beach, California 90806
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Los Angeles, California 90095
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Nashville, Tennessee 37203
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New Brunswick, New Jersey 08901
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New Orleans, Louisiana 70118
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3401 N Broad St
Philadelphia, Pennsylvania
(215) 707-2000
Temple University Hospital On January 18, 1892 a three-story house at 3403 North Broad Street...
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Portland, Oregon 97201
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Rochester, Minnesota 55905
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Sarasota, Florida 34239
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Stanford, California 94305
Phone: 650-725-0232
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Tampa, Florida 33612
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Torrance, California 90502
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Wooster, Ohio 44691
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Worcester, Massachusetts 01608
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York, Pennsylvania 17403
Phone: 717-851-4104
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York, PA
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