Medical Therapy of Prostatic Symptoms



Status:Completed
Conditions:Prostate Cancer, Orthopedic, Hematology, Urology
Therapuetic Areas:Hematology, Nephrology / Urology, Oncology, Orthopedics / Podiatry
Healthy:No
Age Range:50 - Any
Updated:9/30/2018
Start Date:December 1995
End Date:November 30, 2001

Use our guide to learn which trials are right for you!

The Medical Therapy of Prostatic Symptoms (MTOPS) is a clinical research study sponsored by
the National Institutes of Health (NIH). The study will test whether the oral drugs
finasteride (Proscar) and doxazosin (Cardura), alone or together, can delay or prevent
further worsening of symptoms in men with Benign Prostatic Hyperplasia (BPH).

MTOPS is the largest and longest study to simultaneously test whether these drugs can delay
or prevent the clinical progression (symptom worsening) of BPH. Seventeen U.S. medical
centers recruited 2,931 men diagnosed with symptomatic BPH between December 1995 and March
1998. Study doctors will continue to follow these men through November 2001 on a quarterly
basis. In addition to the clinical progression of BPH, MTOPS will include evaluations of
prostate volume by ultrasound, prostate biopsies among a subgroup of volunteers, and quality
of life.


Inclusion Criteria:

- Peak urinary flow rate at least 4 ml/sec but not greater than 15 ml/sec; and voided
volume is at least 125 ml.

- American Urological Association Symptom Score is greater than or equal to 8 and less
than or equal to 30.

- Voluntarily signed the informed consent agreement prior to the performance of any
study procedures.

Exclusion Criteria:

- Serum prostate specific antigen level greater than 10 ng/ml.

- Supine blood pressure less than 90/70 mmHG. Orthostatic hypotension.

- Any prior medical or surgical intervention for BPH.

- Received any prior experimental intervention (either medical or surgical) for prostate
disease or enrolled in any other study protocol.
We found this trial at
17
sites
303 East Superior Street
Chicago, Illinois 60611
?
mi
from
Chicago, IL
Click here to add this to my saved trials
201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
1200 Moursund Street
Houston, Texas 77030
(713) 798-4951
Baylor College of Medicine Baylor College of Medicine in Houston, the only private medical school...
?
mi
from
Houston, TX
Click here to add this to my saved trials
?
mi
from
Aurora, CO
Click here to add this to my saved trials
Baltimore, Maryland 20742
(301) 405-1000
University of Maryland As a globally-connected university offering a world-class education, the University of Maryland...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
2201 Inwood Rd
Dallas, Texas 75235
(214) 645-8300
U.T. Southwestern Medical Center The story of UT Southwestern Medical Center is one of commitment...
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Detroit, Michigan 48202
?
mi
from
Detroit, MI
Click here to add this to my saved trials
200 Hawkins Dr,
Iowa City, Iowa 52242
866-452-8507
University of Iowa Hospitals and Clinics University of Iowa Hospitals and Clinics—recognized as one of...
?
mi
from
Iowa City, IA
Click here to add this to my saved trials
La Jolla, California 92093
?
mi
from
La Jolla, CA
Click here to add this to my saved trials
2201 West End Ave
Nashville, Tennessee 37232
(615) 322-7311
Vanderbilt University Vanderbilt offers undergraduate programs in the liberal arts and sciences, engineering, music, education...
?
mi
from
Nashville, TN
Click here to add this to my saved trials
New Haven, Connecticut 6520
(203) 432-4771
Yale University Yale's roots can be traced back to the 1640s, when colonial clergymen led...
?
mi
from
New Haven, CT
Click here to add this to my saved trials
550 1st Ave
New York, New York 10016
(212) 263-7300
New York University School of Medicine NYU School of Medicine has a proud history that...
?
mi
from
New York, NY
Click here to add this to my saved trials
722 W 168th St
New York, New York 10032
(212) 305-2500
Columbia Presbyterian Med Ctr On January 1, 1998, The New York Hospital publicly announced its...
?
mi
from
New York, NY
Click here to add this to my saved trials
Rochester, Minnesota 55905
?
mi
from
Rochester, MN
Click here to add this to my saved trials
Saint Louis, Missouri 63110
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials
San Antonio, Texas 78234
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
6900 Georgia Ave NW
Washington, District of Columbia 20307
(202) 782-6849
Walter Reed Army Medical Center The Walter Reed National Military Medical Center is one of...
?
mi
from
Washington,
Click here to add this to my saved trials