A Clinical Study to Test Efficacy and Safety of Repeat Doses of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain



Status:Recruiting
Conditions:Arthritis, Osteoarthritis (OA)
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:40 - 95
Updated:4/6/2019
Start Date:September 9, 2018
End Date:May 2020
Contact:Study Manager
Email:info@centrexion.com
Phone:617-837-6911

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A Randomized, Double-blind, Placebo-controlled, 2-Injection, 52-Week Study to Evaluate the Efficacy and Safety of Intra-articular Injections of CNTX-4975-05 in Subjects With Chronic, Moderate-to-severe Osteoarthritis Knee Pain

This is a randomized, double-blind, placebo-controlled, 2-injection, 52-week study to
evaluate the efficacy and safety of intra-articular injections of CNTX-4975-05 in subjects
with chronic, moderate-to-severe osteoarthritis knee pain.


Key Inclusion Criteria:

- Male or female subjects between 40 and 95 years of age (inclusive) at the time of the
Screening Visit with the ability to comply with answering the electronic diary using
the study- provided tablet computers.

- Confirmation of osteoarthritis (OA) of the knee.

- Confirmation of the OA of the index knee.

- Moderate to severe pain in the index knee associated with OA must be stable for a
minimum of 6 months prior to Screening, as assessed by the investigator.

- Body Mass Index (BMI) ≤45 kg/m^2

- Must have failed 2 or more prior therapies.

Exclusion Criteria:

- Joint replacement surgery of the index knee at any time, or open surgery of the index
knee in the past 24 months.

- Prior arthroscopic surgery of the index knee within 6 months of Screening.

- Any painful conditions of the index knee due to joint disease other than the OA.

- Periarticular pain from any cause.

- Other chronic pain anywhere in the body that requires the use of analgesic
medications.

- Instability of the index knee.

- Misalignment (>10 degrees varus or valgus) of the index knee on standing.

- Documented history of neuropathic arthropathy or finding of bony fragmentation in the
index knee with imaging.

- Physical/ occupational/ chiropractic therapy for the lower extremities or acupuncture
for the lower extremities within 30 days of Screening, or need for such therapy during
the study.

- Plans to have surgery, other invasive procedures, or IA injections while participating
in the study.

- Has used topical capsaicin on the index knee within 90 days of Screening.

- Current use of opioids for any condition other than for OA of the index knee.

- Corticosteroid injection into the index knee within 90 days of Screening.

- Received IA viscosupplementation (eg, Synvisc®, Hyalgan®) within 90 days of Screening.
We found this trial at
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Dakota Dunes, South Dakota 57049
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3800 Houma Blvd., Suite 335
Metairie, Louisiana 70006
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7000 SW 62 Ave.
Miami, Florida 33143
305-284-8483
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7940 Floyd Curl Dr.
San Antonio, Texas 78229
210-949-0122
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500 Chase Parkway
Waterbury, Connecticut 06708
203-419-4420
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1897 Palm Beach Lakes Boulevard
West Palm Beach, Florida 33409
561-689-0606
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Bay City, Michigan 48706
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4641 Main Street
Bridgeport, Connecticut 06606
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Carmichael, California 95608
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303 E Chicago Ave
Chicago, Illinois 60611
(312) 503-8194
Northwestern University Feinberg School of Medicine Northwestern University Feinberg School of Medicine, founded in 1859,...
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Danville, Virginia 24541
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El Cajon, California 92020
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Fargo, North Dakota 58103
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Greensboro, North Carolina 27410
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Hartsdale, New York 10530
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Hazelwood, Missouri 63042
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Houston, Texas 77004
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Oak Brook, Illinois 60523
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