Ultra Rapid Culture Independent Detection of High-Priority Carbapenem Resistant Enterobacteriaceae Directly From Blood



Status:Enrolling by invitation
Conditions:Infectious Disease, Infectious Disease, Hematology
Therapuetic Areas:Hematology, Immunology / Infectious Diseases
Healthy:No
Age Range:7 - 89
Updated:8/16/2018
Start Date:July 2015
End Date:January 2020

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The purpose of this study is to develop a new and very rapid diagnostic test for identifying
a certain type of bacteria called Enterobacteriaceae in blood. Rapid identification of
bacteria will assist in decreasing the use of antibiotics and help more patients survive
bacterial infections of the blood.

It is our overall goal to develop a new diagnostic technology that will facilitate
antibacterial stewardship to reduce selective pressure and improve patient outcomes. The
Institute of Medicine has identified antibiotic resistance as one of the key microbial
threats to health in the United States and has prioritized decreasing inappropriate use of
antimicrobials as the primary solution to address this threat. The emergence of carbapenem
resistance among Enterobacteriaceae (CRE) in the United States represents a recent and severe
byproduct of excessive antimicrobial use with a high mortality rate in bacteremia. A major
barrier toward decreasing use of antimicrobials is lack of sensitive and accurate rapid
diagnostic tests for identifying bacterial etiologies of infection.

Inclusion Criteria:

- Laboratory confirmed gram negative bacilli blood culture

Exclusion Criteria:

- Pregnancy

- Prisoner
We found this trial at
2
sites
12605 East 16th Avenue
Aurora, Colorado 80045
720-848-0000
University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...
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777 Bannock St
Denver, Colorado 80204
(303) 436-6000
Denver Health Medical Center Denver Health is a comprehensive, integrated organization providing level one care...
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Denver, CO
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