North American Prodromal Synucleinopathy Consortium



Status:Recruiting
Conditions:Other Indications, Parkinsons Disease, Neurology, Psychiatric
Therapuetic Areas:Neurology, Psychiatry / Psychology, Other
Healthy:No
Age Range:18 - Any
Updated:9/2/2018
Start Date:August 29, 2018
End Date:July 31, 2021
Contact:Yo-El Ju, MD
Email:info@naps-rbd.org
Phone:314-747-6124

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This study will enroll participants with idiopathic rapid eye movement (REM) sleep behavior
disorder (RBD), for the purpose of preparing for a clinical trial of neuroprotective
treatments against synucleinopathies.

REM sleep behavior disorder (RBD) is a rare disorder where people act out their dreams.
People with RBD often, but not always, develop Parkinson's Disease, dementia with Lewy
bodies, multiple system atrophy, or other neurodegenerative diseases of the synucleinopathy
type. The North American Prodromal Synucleinopathy (NAPS) Consortium was formed with the
purpose of enrolling participants with RBD, in anticipation of a future clinical trial of a
neuroprotective treatment against synucleinopathies. The NAPS Consortium will collect
standardized clinical assessments, biofluids, and other data in order to develop biomarkers
for synucleinopathies in the prodromal (presymptomatic) stage as well as a trial-ready
registry of participants. Participants procedures will include a ~2-hour clinical assessment
(medical history and physical exam), questionnaires, blood draw, and (at select sites)
optional lumbar puncture.

Inclusion Criteria:

- Idiopathic REM sleep behavior disorder

Exclusion Criteria:

- REM sleep behavior disorder secondary to another cause (ex: narcolepsy, dementia,
Parkinson's Disease, etc)

- Other neurological disorder
We found this trial at
7
sites
Montreal, Quebec
Principal Investigator: Ronald Postuma, MD
Phone: 514-934-1934
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201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Principal Investigator: Daniel Huddleston, MD
Phone: 404-712-6988
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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Atlanta, GA
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
Principal Investigator: Aleksandar Videnovic, MD
Phone: 617-724-2644
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Boston, MA
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Los Angeles, California 90095
310-825-4321
Principal Investigator: Alon Avidan, MD
Phone: 310-825-0703
University of California at Los Angeles The University of California, Los Angeles (UCLA) is an...
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Los Angeles, CA
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Minneapolis, Minnesota 55455
(612) 625-5000
Principal Investigator: Michael Howell, MD
Phone: 612-624-9025
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
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Minneapolis, MN
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Rochester, Minnesota 55905
Principal Investigator: Bradley Boeve, MD
Phone: 507-284-1324
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Rochester, MN
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Saint Louis, Missouri 63110
Principal Investigator: Yo-El Ju, MD
Phone: 314-747-6124
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Saint Louis, MO
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