Maladaptive Adipose Tissue Activity in Cancer

The purpose of this research is to study brown adipose tissue, a type of fat that increases
metabolism (burns energy) during exposure to cold, and how it may contribute to the weight
loss observed in cancer. Many patients affected by cancer lose weight, despite normal or
increased nutrition. It may progress to the condition called "cancer-associated cachexia."
Cancer associated cachexia is defined by an ongoing loss of skeletal muscle mass with or
without the loss of fat mass, and may negatively affect quality of life and the ability to
undergo cancer treatments. Metabolism is the breakdown of food by the body into the energy
that your body needs.

Inclusion Criteria:

- ≥ 40 years of age

- Have active cancer diagnosis.

- Have had a PET/CT scan within the past 12 months at time of enrollment.

- Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

- Current use of beta-blockers

- Women who are pregnant or unsure of their pregnancy status

- Women who are breastfeeding

- Suffers from severe claustrophobia

- Diagnosed with a serious psychiatric condition which could impede the judgement of the
investigators, and/or the successful conduct of the recording.

- In remission stage for cancer diagnosis