An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis [EXPEDITION]



Status:Recruiting
Conditions:Colitis, Gastrointestinal
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - 80
Updated:3/21/2019
Start Date:August 7, 2018
End Date:February 14, 2021
Contact:Clinical Trials Registry Team
Email:IR‐CTRegistration@Allergan.com
Phone:877‐277‐8566

Use our guide to learn which trials are right for you!

A 54-Week Treatment, Multicenter, Randomized, Double-Blind, Double-Dummy, Placebo and Active-Controlled, Parallel-Group Phase 2 Study to Assess the Efficacy and Safety of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis

The present study (3151-201-008) seeks to evaluate the efficacy and safety of brazikumab
versus placebo in patients with moderately to severely active UC and will include assessments
of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal
appearance as observed on endoscopy.


Inclusion Criteria:

- Diagnosis of UC for at least 3 months.

- Inadequate response or intolerance to conventional therapy for the treatment of
ulcerative colitis

- Evidence of active UC based on the modified Mayo score

- No known history of active TB

- Agree to practicing abstinence or adhering to specific birth control requirements

Exclusion Criteria:

- Participant has UC limited to the rectum

- History of fulminant colitis, a diagnosis of Crohn's disease or indeterminate colitis
specific complication of UC, including toxic megacolon

- Previous intolerance or non-response to vedolizumab

- Participants receiving exclusionary treatment within specified time periods

- History of cancer, except for basal cell carcinoma, squamous cell carcinoma, or
carcinoma in situ of the cervix.

- Clinically significant infections

- Clinically significant cardiovascular conditions
We found this trial at
46
sites
Camarillo, California 93012
?
mi
from
Camarillo, CA
Click here to add this to my saved trials
8420 S. Eastern Ave.
Las Vegas, Nevada 89123
702-898-2088
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
Albuquerque, New Mexico 87108
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
Amarillo, Texas 79106
?
mi
from
Amarillo, TX
Click here to add this to my saved trials
Astoria, New York 11104
?
mi
from
Astoria, NY
Click here to add this to my saved trials
Baton Rouge, Louisiana 70809
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
Biloxi, Mississippi 39531
?
mi
from
Biloxi, MS
Click here to add this to my saved trials
Boca Raton, Florida 33487
?
mi
from
Boca Raton, FL
Click here to add this to my saved trials
Brooklyn, New York 11230
?
mi
from
Brooklyn, NY
Click here to add this to my saved trials
Brownsburg, Indiana 46112
?
mi
from
Brownsburg, IN
Click here to add this to my saved trials
Carrollton, Texas 75007
?
mi
from
Carrollton, TX
Click here to add this to my saved trials
Chula Vista, California 91911
?
mi
from
Chula Vista, CA
Click here to add this to my saved trials
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
Clearwater, Florida 33756
?
mi
from
Clearwater, FL
Click here to add this to my saved trials
Colorado Springs, Colorado 80907
?
mi
from
Colorado Springs, CO
Click here to add this to my saved trials
Cutler Bay, Florida 33157
?
mi
from
Cutler Bay, FL
Click here to add this to my saved trials
Cutler Bay, Florida 33189
?
mi
from
Cutler Bay, FL
Click here to add this to my saved trials
Edmonton, Alberta
?
mi
from
Edmonton,
Click here to add this to my saved trials
12772 Valley View Street
Garden Grove, California 92845
?
mi
from
Garden Grove, CA
Click here to add this to my saved trials
Gurnee, Illinois 60031
?
mi
from
Gurnee, IL
Click here to add this to my saved trials
8206 Northwest 103rd Street
Hialeah, Florida 33016
?
mi
from
Hialeah, FL
Click here to add this to my saved trials
14903 El Camino Real
Houston, Texas 77062
?
mi
from
Houston, TX
Click here to add this to my saved trials
4671 South Congress Avenue
Lake Worth, Florida 33461
?
mi
from
Lake Worth, FL
Click here to add this to my saved trials
Lancaster, California 93534
?
mi
from
Lancaster, CA
Click here to add this to my saved trials
Las Vegas, Nevada 89106
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
Little Rock, Arkansas 72212
?
mi
from
Little Rock, AR
Click here to add this to my saved trials
Los Angeles, California 90036
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
1101 Medical Center Boulevard
Marrero, Louisiana 70072
?
mi
from
Marrero, LA
Click here to add this to my saved trials
3400 Southwest 107th Avenue
Miami, Florida 33165
?
mi
from
Miami, FL
Click here to add this to my saved trials
Miami, Florida 33157
?
mi
from
Miami, FL
Click here to add this to my saved trials
611 North 35th Street
Morehead City, North Carolina 28557
?
mi
from
Morehead City, NC
Click here to add this to my saved trials
New Port Richey, Florida 34653
?
mi
from
New Port Richey, FL
Click here to add this to my saved trials
New York, New York 10024
?
mi
from
New York, NY
Click here to add this to my saved trials
Norman, Oklahoma 73069
?
mi
from
Norman, OK
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73112
?
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
Poway, California 92064
?
mi
from
Poway, CA
Click here to add this to my saved trials
Richmond, Virginia
?
mi
from
Richmond, VA
Click here to add this to my saved trials
San Bernardino, California 92408
?
mi
from
San Bernardino, CA
Click here to add this to my saved trials
San Diego, California 92103
?
mi
from
San Diego, CA
Click here to add this to my saved trials
San Diego, California 92117
?
mi
from
San Diego, CA
Click here to add this to my saved trials
San Diego, California 92114
?
mi
from
San Diego, CA
Click here to add this to my saved trials
San Pablo, California 94806
?
mi
from
San Pablo, CA
Click here to add this to my saved trials
Tampa, Florida 33626
?
mi
from
Tampa, FL
Click here to add this to my saved trials
Topeka, Kansas 66614
?
mi
from
Topeka, KS
Click here to add this to my saved trials
Tucson, Arizona 85710
?
mi
from
Tucson, AZ
Click here to add this to my saved trials
Wayne, California 95648
?
mi
from
Wayne, CA
Click here to add this to my saved trials