CALM- 2 - Controlling and Lowering Blood Pressure With the MobiusHD™



Status:Recruiting
Conditions:High Blood Pressure (Hypertension)
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - 80
Updated:3/2/2019
Start Date:October 19, 2017
End Date:May 2026
Contact:Tamara Shipman, BSN
Email:tshipman@vasculardynamics.com
Phone:650-208-1118

Use our guide to learn which trials are right for you!

The objective of this study is to evaluate the safety and effectiveness of the MobiusHD
System in a prospective, randomized, double-blind, sham-controlled multi-center pivotal
study.

The objective of this study is to evaluate the safety and effectiveness of the MobiusHD
System in a prospective, randomized, double-blind, sham-controlled multi-center pivotal
study. Patients with resistant hypertension who remain uncontrolled despite pharmacologic
treatment with maximum tolerated, guideline-directed anti-hypertensive pharmacologic therapy
will be evaluated.

Inclusion Criteria:

- Mean 24 hour ambulatory systolic blood pressure ≥145 mmHg and ≤200 mmHg and stable for
at least 8 weeks on a maximally tolerated guideline directed, (JNC8) or their
equivalent when those listed are not available dosing regimen consisting of up to 5
antihypertensive medications, with a minimum required dosing regimen of an "A+C+D"
antihypertensive medication regimen, where "A" is an angiotensin-converting enzyme
Inhibitor or an angiotensin receptor blocker, "C" is a calcium channel blocker, and
"D" is a diuretic.

Exclusion Criteria:

- Inadequacy of the carotid anatomy for treatment with the MobiusHD based on carotid
angiography.
We found this trial at
17
sites
Cincinnati, Ohio 45219
Principal Investigator: John J Szawaluk, MD, FACC, FAHA, FSCTT
Phone: 513-585-1777
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Cincinnati, OH
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
Principal Investigator: Suzanne Oparil, MD, FACC, FAHA, FASH, FAPS
Phone: 205-934-7279
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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Birmingham, AL
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
Principal Investigator: Sandeep Nathan, MD
Phone: 347-506-8518
University of Chicago One of the world's premier academic and research institutions, the University of...
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Chicago, IL
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Los Angeles, California 90033
213) 740-2311
Principal Investigator: Mitra Nadim, MD
Phone: 323-442-5693
University of Southern California The University of Southern California is one of the world’s leading...
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Los Angeles, CA
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550 Peachtree St NE
Atlanta, Georgia 30308
(404) 686-4411
Principal Investigator: Janice Lea, MD, MSc, FASN
Phone: 404-686-3872
Emory University Hospital Midtown Emory University Hospital Midtown is a 511-bed community-based, acute care teaching...
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Atlanta, GA
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Beaumont, Texas 77702
Principal Investigator: Paris P Bransford, MD
Phone: 409-839-4003
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Beaumont, TX
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Lambeth, London
Principal Investigator: Philip J Chowienczyk
Phone: +44 (0) 207 188 4768
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from
Lambeth,
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Lexington, Kentucky 40536
Principal Investigator: John R Kotter, MD
Phone: 859-323-1082
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from
Lexington, KY
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New Haven, Connecticut 6520
(203) 432-4771
Principal Investigator: Aldo Peixoto, MD
Phone: 203-737-8010
Yale University Yale's roots can be traced back to the 1640s, when colonial clergymen led...
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New Haven, CT
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1514 Jefferson Hwy.
New Orleans, Louisiana 70121
504-842-3000
Principal Investigator: Michael E Cash, MD
Phone: 504-842-8093
Ochsner Medical Center Ochsner Medical Center is located near uptown New Orleans and includes acute...
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New Orleans, LA
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Philadelphia, Pennsylvania 19141
Principal Investigator: Vincent M Figueredo, MD, FAHA, FACC
Phone: 215-456-6736
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Philadelphia, PA
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Reno, Nevada 89502
Principal Investigator: Michael J Bloch, MD, FACP, FASH, FSVM, FNLA
Phone: 775-982-2045
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Reno, NV
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18001 East 10 Mile Road
Roseville, Michigan 48066
Principal Investigator: Christopher R Provenzano, MD
Phone: 313-432-6254
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Roseville, MI
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5300 Tallman Ave NW
Seattle, Washington 98122
(206) 782-2700
Principal Investigator: Vijay Vidyasagar, MD
Phone: 206-386-6462
Swedish Medical Center Since 1910, Swedish has been the region's hallmark for excellence in health...
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Seattle, WA
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327 W Calhoun Ave
Springfield, Illinois 62702
(217) 545-0223
Principal Investigator: John M Flack, MD, MPH, FAHA, FASH
Phone: 217-545-4402
Southern Illinois University From its humble beginnings as the state's second teachers college - founded...
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Springfield, IL
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Tampa, Florida 33614
Principal Investigator: Jesus O Nvarro, MD
Phone: 813-873-1016
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Tampa, FL
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West Des Moines, Iowa 50266
Principal Investigator: Randolph R Rough, MD
Phone: 515-633-3845
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from
West Des Moines, IA
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