CALM- 2 - Controlling and Lowering Blood Pressure With the MobiusHD™



Status:Recruiting
Conditions:High Blood Pressure (Hypertension)
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - 80
Updated:3/2/2019
Start Date:October 19, 2017
End Date:May 2026
Contact:Tamara Shipman, BSN
Email:tshipman@vasculardynamics.com
Phone:650-208-1118

Use our guide to learn which trials are right for you!

The objective of this study is to evaluate the safety and effectiveness of the MobiusHD
System in a prospective, randomized, double-blind, sham-controlled multi-center pivotal
study.

The objective of this study is to evaluate the safety and effectiveness of the MobiusHD
System in a prospective, randomized, double-blind, sham-controlled multi-center pivotal
study. Patients with resistant hypertension who remain uncontrolled despite pharmacologic
treatment with maximum tolerated, guideline-directed anti-hypertensive pharmacologic therapy
will be evaluated.

Inclusion Criteria:

- Mean 24 hour ambulatory systolic blood pressure ≥145 mmHg and ≤200 mmHg and stable for
at least 8 weeks on a maximally tolerated guideline directed, (JNC8) or their
equivalent when those listed are not available dosing regimen consisting of up to 5
antihypertensive medications, with a minimum required dosing regimen of an "A+C+D"
antihypertensive medication regimen, where "A" is an angiotensin-converting enzyme
Inhibitor or an angiotensin receptor blocker, "C" is a calcium channel blocker, and
"D" is a diuretic.

Exclusion Criteria:

- Inadequacy of the carotid anatomy for treatment with the MobiusHD based on carotid
angiography.
We found this trial at
17
sites
5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
Principal Investigator: Sandeep Nathan, MD
Phone: 347-506-8518
University of Chicago One of the world's premier academic and research institutions, the University of...
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Chicago, IL
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
Principal Investigator: Suzanne Oparil, MD, FACC, FAHA, FASH, FAPS
Phone: 205-934-7279
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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Birmingham, AL
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Los Angeles, California 90033
213) 740-2311
Principal Investigator: Mitra Nadim, MD
Phone: 323-442-5693
University of Southern California The University of Southern California is one of the world’s leading...
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Los Angeles, CA
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550 Peachtree St NE
Atlanta, Georgia 30308
(404) 686-4411
Principal Investigator: Janice Lea, MD, MSc, FASN
Phone: 404-686-3872
Emory University Hospital Midtown Emory University Hospital Midtown is a 511-bed community-based, acute care teaching...
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Atlanta, GA
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Beaumont, Texas 77702
Principal Investigator: Paris P Bransford, MD
Phone: 409-839-4003
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Beaumont, TX
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Cincinnati, Ohio 45219
Principal Investigator: John J Szawaluk, MD, FACC, FAHA, FSCTT
Phone: 513-585-1777
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Cincinnati, OH
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Lambeth, London
Principal Investigator: Philip J Chowienczyk
Phone: +44 (0) 207 188 4768
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from
Lambeth,
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Lexington, Kentucky 40536
Principal Investigator: John R Kotter, MD
Phone: 859-323-1082
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from
Lexington, KY
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New Haven, Connecticut 6520
(203) 432-4771
Principal Investigator: Aldo Peixoto, MD
Phone: 203-737-8010
Yale University Yale's roots can be traced back to the 1640s, when colonial clergymen led...
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New Haven, CT
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1514 Jefferson Hwy.
New Orleans, Louisiana 70121
504-842-3000
Principal Investigator: Michael E Cash, MD
Phone: 504-842-8093
Ochsner Medical Center Ochsner Medical Center is located near uptown New Orleans and includes acute...
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New Orleans, LA
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Philadelphia, Pennsylvania 19141
Principal Investigator: Vincent M Figueredo, MD, FAHA, FACC
Phone: 215-456-6736
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Philadelphia, PA
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Reno, Nevada 89502
Principal Investigator: Michael J Bloch, MD, FACP, FASH, FSVM, FNLA
Phone: 775-982-2045
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Reno, NV
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18001 East 10 Mile Road
Roseville, Michigan 48066
Principal Investigator: Christopher R Provenzano, MD
Phone: 313-432-6254
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Roseville, MI
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5300 Tallman Ave NW
Seattle, Washington 98122
(206) 782-2700
Principal Investigator: Vijay Vidyasagar, MD
Phone: 206-386-6462
Swedish Medical Center Since 1910, Swedish has been the region's hallmark for excellence in health...
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Seattle, WA
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327 W Calhoun Ave
Springfield, Illinois 62702
(217) 545-0223
Principal Investigator: John M Flack, MD, MPH, FAHA, FASH
Phone: 217-545-4402
Southern Illinois University From its humble beginnings as the state's second teachers college - founded...
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Springfield, IL
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Tampa, Florida 33614
Principal Investigator: Jesus O Nvarro, MD
Phone: 813-873-1016
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Tampa, FL
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West Des Moines, Iowa 50266
Principal Investigator: Randolph R Rough, MD
Phone: 515-633-3845
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West Des Moines, IA
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