Discontinuation From Chronic Opioid Therapy For Pain Using a Buprenorphine Taper
| Status: | Recruiting |
|---|---|
| Conditions: | Chronic Pain, Chronic Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 5/19/2018 |
| Start Date: | May 2016 |
| End Date: | January 2020 |
| Contact: | Kayla Research Specialist |
| Email: | whaley@musc.edu |
| Phone: | 843-792-0684 |
Chronic opioid therapy for pain can be associated with significant risks, and a significant
number of patients maintained on chronic opioids have continued pain and/or poor functioning.
When patients need to or want to come off their opioid pain medications, there is little to
guide physicians as to how to best help them do so, and it is not known how patients do after
coming off opioid medications. The goals of this study are (1) to evaluate two medications in
assisting patients in coming off their opioid pain medications and (2) determining outcomes
after discontinuing opioids.
number of patients maintained on chronic opioids have continued pain and/or poor functioning.
When patients need to or want to come off their opioid pain medications, there is little to
guide physicians as to how to best help them do so, and it is not known how patients do after
coming off opioid medications. The goals of this study are (1) to evaluate two medications in
assisting patients in coming off their opioid pain medications and (2) determining outcomes
after discontinuing opioids.
Inclusion Criteria:
- 18 - 55 years of age
- Ability to speak and read in English
- Currently taking chronic opioid therapy for pain for at least 6 months
- On opioid dose of >60mg and <200mg oral morphine equivalents/day
- Voluntarily seeking opioid discontinuation
- Willing to attempt buprenorphine-assisted opioid discontinuation
- Willing to be randomized to gabapentin or placebo
- Have current physician who is actively prescribing opioids and who will be notified by
the research team of the patient's entry into the study.
Exclusion Criteria:
- Previous intolerance or allergy to buprenorphine or gabapentin
- Diagnostic & Statistical Manual -V criteria for substance use disorder currently or in
the past (other than nicotine)
- Unstable medical or psychiatric condition that would preclude safe or meaningful
participation (e.g. traumatic brain injury; severe mental illness; severe cardiac,
renal, pulmonary, or liver disease)
- Current use of benzodiazepines or illicit drugs
- Maintenance on fentanyl or methadone
- Current treatment with gabapentin
We found this trial at
1
site
171 Ashley Avenue
Charleston, South Carolina 29425
Charleston, South Carolina 29425
843-792-1414
Principal Investigator: Kelly Barth, DO
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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