Assessment of INS1007 in Subjects With Non-Cystic Fibrosis Bronchiectasis



Status:Recruiting
Conditions:Pulmonary
Therapuetic Areas:Pulmonary / Respiratory Diseases
Healthy:No
Age Range:18 - 85
Updated:3/31/2019
Start Date:December 1, 2017
End Date:June 2020
Contact:Tomoko Shibata
Email:tomoko.shibata@insmed.com
Phone:+1.908.947.2821

Use our guide to learn which trials are right for you!

Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center Study to Assess the Efficacy, Safety & Tolerability, and PK of INS1007 Administered Once Daily for 24 Weeks in Subjects With Non-CF Bronchiectasis - The Willow Study

The purpose of the study is to evaluate if INS1007 can reduce pulmonary exacerbations over a
24-week treatment period in patients with non-cystic fibrosis bronchiectasis.

Phase 2 randomized, double-blind, placebo-controlled, parallel-group, multicenter,
multi-national study to assess the efficacy, safety and tolerability, and pharmacokinetics
(PK) of INS1007 administered once daily for 24 weeks in subjects with non-cystic fibrosis
bronchiectasis (NCFBE).

Inclusion Criteria:

1. Clinical history consistent with NCFBE (cough, chronic sputum production and/or
recurrent respiratory infections)

2. Are current sputum producers with a history of chronic expectoration and able to
provide a sputum sample during Screening

3. Have at least 2 documented pulmonary exacerbations in the past 12 months before
Screening

Exclusion Criteria:

1. Have a primary diagnosis of chronic obstructive pulmonary disease (COPD) or asthma

2. Have bronchiectasis due to cystic fibrosis (CF), hypogammaglobulinemia, common
variable immunodeficiency, or alpha1-antitrypsin deficiency

3. Are current smokers

4. Are currently being treated for a nontuberculous mycobacterial lung infection,
allergic bronchopulmonary aspergillosis, or tuberculosis

5. Have any acute infections, (including respiratory infections)
We found this trial at
37
sites
Tacoma, Washington 98405
Principal Investigator: Stephen Ryan
Phone: 253-403-0389
?
mi
from
Tacoma, WA
Click here to add this to my saved trials
1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
Principal Investigator: George Solomon
Phone: 205-638-5599
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
Chapel Hill, North Carolina 27599
(919) 962-2211
Principal Investigator: Peadar Noone
Phone: 984-974-2972
University of North Carolina at Chapel Hill Carolina’s vibrant people and programs attest to the...
?
mi
from
Chapel Hill, NC
Click here to add this to my saved trials
5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
Principal Investigator: Pamela McShane
Phone: 773-834-4053
University of Chicago One of the world's premier academic and research institutions, the University of...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
9500 Euclid Avenue
Cleveland, Ohio 44106
216.444.2200
Principal Investigator: Elliott Dasenbrook
Phone: 216-445-6671
Cleveland Clinic Cleveland Clinic is committed to principles as presented in the United Nations Global...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
Gainesville, Florida 32610
(352) 392-3261
Principal Investigator: Jorge Lascano
Phone: 352-273-5870
University of Florida The University of Florida (UF) is a major, public, comprehensive, land-grant, research...
?
mi
from
Gainesville, FL
Click here to add this to my saved trials
101 Jessup Hall
Iowa City, Iowa 52242
(319) 335-3500
Principal Investigator: Douglas Hornick
Phone: 319-356-3241
University of Iowa With just over 30,000 students, the University of Iowa is one of...
?
mi
from
Iowa City, IA
Click here to add this to my saved trials
1601 Northwest 12th Avenue
Miami, Florida 33136
(305) 243-6545
Principal Investigator: Maria Gabriela Tupayachi Ortiz
Phone: 305-243-5545
University of Miami Miller School of Medicine The University of Miami Leonard M. Miller School...
?
mi
from
Miami, FL
Click here to add this to my saved trials
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Principal Investigator: Kevin Winthrop
Phone: 503-494-1384
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
?
mi
from
Portland, OR
Click here to add this to my saved trials
Sacramento, California 95814
Principal Investigator: Brian Morrissey
Phone: 916-734-3563
?
mi
from
Sacramento, CA
Click here to add this to my saved trials
1500 East Medical Center Drive
Ann Arbor, Michigan 48109
Principal Investigator: Shijing Jia
Phone: 734-232-1386
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Atlanta, Georgia 30342
Principal Investigator: Colin Swenson
Phone: 404-251-1650
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Baltimore, Maryland 21205
Principal Investigator: Mark Jennings
Phone: 410-614-1409
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Celebration, Florida 34747
Principal Investigator: Fred Umeh
Phone: 407-507-2615
?
mi
from
Celebration, FL
Click here to add this to my saved trials
Charlotte, North Carolina 28215
Principal Investigator: Carl Smart
Phone: 704-264-1400
?
mi
from
Charlotte, NC
Click here to add this to my saved trials
Clearwater, Florida 33765
Principal Investigator: Francis Averill
Phone: 727-210-4606
?
mi
from
Clearwater, FL
Click here to add this to my saved trials
Cleveland, Ohio 44012
Principal Investigator: Rodney Folz
Phone: 216-844-2371
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
Concord, New South Wales
Principal Investigator: Lucy Morgan
Phone: 61 297676334
?
mi
from
Concord,
Click here to add this to my saved trials
Denver, Colorado 80206
Principal Investigator: Charles Daley
Phone: 303-270-2622
?
mi
from
Denver, CO
Click here to add this to my saved trials
Farmington, Connecticut 06030
Principal Investigator: Mark Metersky, MD
?
mi
from
Farmington, CT
Click here to add this to my saved trials
Mesquite, Texas 75149
Principal Investigator: Salma Saiger
Phone: 972-216-5152
?
mi
from
Mesquite, TX
Click here to add this to my saved trials
Miami Lakes, Florida 33014
Principal Investigator: Idalia Acosta
Phone: 305-424-7420
?
mi
from
Miami Lakes, FL
Click here to add this to my saved trials
New Orleans, Louisiana 70112
Principal Investigator: Juzar Ali
Phone: 504-568-3450
?
mi
from
New Orleans, LA
Click here to add this to my saved trials
New York, New York 10016
Principal Investigator: Doreen Addrizzo-Harris
Phone: 212-263-7951
?
mi
from
New York, NY
Click here to add this to my saved trials
New York, New York 10032
Principal Investigator: Angela DiMango
Phone: 212-342-4167
?
mi
from
New York, NY
Click here to add this to my saved trials
1501 Superior Avenue
Newport Beach, California 92663
Principal Investigator: Ryan Klein, MD
Phone: 949-791-8599
?
mi
from
Newport Beach, CA
Click here to add this to my saved trials
Palm Springs, California 92262
Principal Investigator: Ziad Tannous
Phone: 760-778-7799
?
mi
from
Palm Springs, CA
Click here to add this to my saved trials
Peoria, Arizona 85381
Principal Investigator: Robert Orr
Phone: 623-523-6430
?
mi
from
Peoria, AZ
Click here to add this to my saved trials
3451 Walnut St
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Principal Investigator: Daniel Dorgan
Phone: 215-662-3115
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
3401 N Broad St
Philadelphia, Pennsylvania
(215) 707-2000
Principal Investigator: Wissam Chatila
Phone: 215-707-9527
Temple University Hospital On January 18, 1892 a three-story house at 3403 North Broad Street...
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Sarasota, Florida 34239
Principal Investigator: Rabin Loutfi
Phone: 941-917-1669
?
mi
from
Sarasota, FL
Click here to add this to my saved trials
300 Pasteur Dr
Stanford, California 94305
(650) 723-4000
Principal Investigator: Stephen Rouss
Phone: 650-723-7409
Stanford Univ Med Ctr The Medical Center is uniquely advantaged by its location on the...
?
mi
from
Stanford, CA
Click here to add this to my saved trials
Towson, Maryland 21204
Principal Investigator: Linda Barr
Phone: 410-494-1662
?
mi
from
Towson, MD
Click here to add this to my saved trials
Tyler, Texas 75708
Principal Investigator: David Griffith
Phone: 903-877-8246
?
mi
from
Tyler, TX
Click here to add this to my saved trials
Washington, District of Columbia 20007
Principal Investigator: Anne O'Donnell
Phone: 202-444-0895
?
mi
from
Washington,
Click here to add this to my saved trials
Westminster, Maryland 21157
Principal Investigator: Amit Narula
Phone: 410-848-3858
?
mi
from
Westminster, MD
Click here to add this to my saved trials
Winston-Salem, North Carolina 27103
Principal Investigator: Barry Sigal
Phone: 336-659-8414
?
mi
from
Winston-Salem, NC
Click here to add this to my saved trials