Human Mesenchymal Stem Cells (LMSCs) on Vaccine-Specific Antibody- Response in Subjects With Aging Frailty

Age Range:65 - 90
Start Date:November 2016
End Date:December 2019
Contact:Suzanne Page
Phone:(305) 909-0850

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Effects of Intravenous Delivery of Longeveron Human Mesenchymal Stem Cells (LMSCs) on Vaccine-Specific Antibody Responses in Subjects With Aging Frailty

This is a phase I/II, randomized, blinded and placebo-controlled study to test the safety and
efficacy of LMCSs for improving vaccine immune response.

A pilot phase will consist of a 3 subject safety run-in, followed by 20 subject randomized
phase to evaluate influenza vaccine response at 1 week and 4 weeks post infusion of LMSCs.
This will be followed by a double-blinded, randomized, placebo-controlled phase.

Inclusion Criteria:

- be willing and able to provide written informed consent and comply with all procedures
required by the protocol.

- be 65 - 90 years of age at the time of signing the Informed Consent Form.

- have a diagnosis of Aging Frailty, with a score of 4 to 7 using the Canadian Frailty

- have a six-minute walk test (6MWT) distance of 200m - 400m for each of 2 trials, and
the 2 trials must be within 15% of each other.

- have total bilirubin between 0.3 - 1.9 mg/dL.

Exclusion Criteria:

- be unwilling or unable to perform any of the assessments required by the Protocol.

- score ≤24 on the Mini Mental State Examination (MMSE).

- have previously received current year's flu-vaccine.

- have any contraindication to receiving a vaccine.

- have a Hemoglobin A1c (HbA1c) level >9.0%.

- be diagnosed with malignancy (subjects without a recurrence in the last 2.5 years will
be allowed) except curatively-treated basal cell carcinoma, melanoma in situ, or
cervical carcinoma.

- have a condition that projected to limit the life-expectancy to ≤1 year.

- have autoimmune disease (e.g., rheumatoid arthritis).

- be using medication(s) known to alter immune response, e.g., high-dose

- have HIV, AIDS, or other immunodeficiency.

- test positive for hepatitis B virus

- If the subject tests positive for anti-HBc or anti-HBs, they must be receiving
treatment for Hepatitis B virus prior to infusion and remain on treatment
throughout the study.

- test positive for verimic hepatitis C, HIV1, HIV2, or syphilis.

- have a resting blood oxygen saturation of <93% (measured by pulse oximetry).

- be a female who is pregnant, nursing, or of childbearing potential while not
practicing effective contraception.

- have documented current substance and/or alcohol abuse.

- have known allergies to latex or eggs.

- have a known hypersensitivity to dimethyl sulfoxide (DMSO).

- be an organ transplant recipient (other than corneal, bone, skin, ligament, or tendon

- be actively listed (or expected to be listed) for transplant of any organ (other than
corneal, bone, skin, ligament, or tendon transplant).

- have any clinically important abnormal screening laboratory values, including but not
limited to:

- hemoglobin <10.0 g/dL.

- white blood cell count < 2500/mm3.

- platelets < 100,000/mm3.

- prothrombin time/international normalized ratio (PT/INR) ˃ 1.5 not due to a
reversible cause (i.e. Coumadin).

- aspartate transaminase, alanine transaminase, or alkaline phosphatase ˃ 2 times
upper limit of normal.

- have a sitting or resting systolic blood pressure >180 mm Hg or diastolic blood
pressure >110 mm Hg at Screening.

- have any serious illness or any other condition that, in the opinion of the
investigator, may compromise the safety or compliance of the subject or preclude
successful completion of the study, or that may compromise the validity of the study.

- be currently participating in an investigational therapeutic or device trial, or have
participated in an investigational therapeutic or device trial within the previous 30
days, or participate in any other clinical trial for the duration of the time that the
subject actively participates in this trial.
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(305) 284-2211
Principal Investigator: Dushyantha T. Jayaweera, MD
Phone: 305-243-1152
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