Efficacy Study of p38 Kinase Inhibitor to Treat Patients With Atherosclerosis
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 75 |
| Updated: | 4/21/2016 |
| Start Date: | December 2008 |
| End Date: | December 2010 |
A 12-Week, Randomized, Semi Double-Blinded Study Evaluating the Effects of Daily Oral High-Dose Atorvastatin or BMS-582949 on Atherosclerotic Plaque Inflammation as Determined by FDG-PET in High Risk Atherosclerotic Patients
The purpose of the study is to determine whether a p38 kinase inhibitor reduces inflammation
in atherosclerotic plaque
in atherosclerotic plaque
Inclusion Criteria:
- History of documented atherosclerosis
- LDL between 70 and 130 mg/dL
- Patients receiving stable low- to moderate-dose statin
- BMI 18-37 kg/m²
- Must be able to swallow tablets
- Must be able to medically tolerate the procedures, contrast medium, and medications
involved
Exclusion Criteria:
- Statin intolerance
- Renal impairment (serum creatinine > 1.5 mg/dL)
- History of chronic viral hepatitis or other liver dysfunction
- Major infection requiring hospitalization or receipt of IV antibiotics due to an
infection within 2 months prior to initiation of study treatment
We found this trial at
17
sites
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Baylor College of Medicine Baylor College of Medicine in Houston, the only private medical school...
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240 East Ayr Parkway
Madisonville, Kentucky 42431
Madisonville, Kentucky 42431
888-569-8930
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3400 Spruce St
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
(215) 662-4000
Hospital of the University of Pennsylvania The Hospital of the University of Pennsylvania (HUP) is...
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