Phase 1/2 Study of Mocetinostat and Durvalumab in Patients With Advanced Solid Tumors and NSCLC
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 12/8/2018 |
| Start Date: | May 2016 |
| End Date: | May 2019 |
A Phase 1/2 Study of HDAC Inhibitor, Mocetinostat, in Combination With PD-L1 Inhibitor, Durvalumab, in Advanced or Metastatic Solid Tumors and Non-Small Cell Lung Cancer
Mocetinostat (MGCD0103) is an orally administered HDAC inhibitor. Durvalumab (MEDI4736) is a
human monoclonal antibody that is an inhibitor of the Programmed Cell Death Ligand (or
PD-L1). Durvalumab is also known as a checkpoint inhibitor.
This study is evaluating the combination regimen of mocetinostat and durvalumab in subjects
with Advanced or Metastatic Solid Tumors and Non-Small Cell Lung Cancer.
Patients eligible for this study may have previously received treatment with a checkpoint
inhibitor.
human monoclonal antibody that is an inhibitor of the Programmed Cell Death Ligand (or
PD-L1). Durvalumab is also known as a checkpoint inhibitor.
This study is evaluating the combination regimen of mocetinostat and durvalumab in subjects
with Advanced or Metastatic Solid Tumors and Non-Small Cell Lung Cancer.
Patients eligible for this study may have previously received treatment with a checkpoint
inhibitor.
The treatment regimen will begin with a 7-Day Lead-in Period of mocetinostat alone followed
by start of the combination regimen of mocetinostat and durvalumab. The Recommended Phase 2
Dose of mocetinostat will be established in the Phase 1 dose escalation segment, followed by
evaluation of the clinical activity of the combination regimen in Phase 2.
by start of the combination regimen of mocetinostat and durvalumab. The Recommended Phase 2
Dose of mocetinostat will be established in the Phase 1 dose escalation segment, followed by
evaluation of the clinical activity of the combination regimen in Phase 2.
Inclusion Criteria:
- Phase 1-Diagnosis of advanced or metastatic solid tumor; Phase 2-Diagnosis of NSCLC
- Not amenable to treatment with curative intent
- Adequate bone marrow and organ function
Exclusion Criteria:
- Impaired heart function
- Uncontrolled tumor in the brain
- Other active cancer
We found this trial at
15
sites
Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
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Montefiore Medical Center As the academic medical center and University Hospital for Albert Einstein College...
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675 N Saint Clair St # 21-100
Chicago, Illinois 60611
Chicago, Illinois 60611
(312) 695-1156
Robert H. Lurie Comprehensive Cancer Center at Northwestern University The cancer center was first established...
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Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
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10833 Le Conte Ave
Los Angeles, California 90095
Los Angeles, California 90095
(310) 825-4321
David Geffen School of Medicine, UCLA In 2002 Mr. David Geffen announced a $200 million...
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909 Fulton Street Southeast
Minneapolis, Minnesota 55414
Minneapolis, Minnesota 55414
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3322 West End Avenue
Nashville, Tennessee 37203
Nashville, Tennessee 37203
(615)329-SCRI (7274)
Sarah Cannon Research Institute Sarah Cannon Research Institute (SCRI) is a global strategic research organization...
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