Children's Respiratory and Environmental Workgroup

Status:Enrolling by invitation
Conditions:Allergy, Allergy, Asthma, Healthy Studies
Therapuetic Areas:Otolaryngology, Pulmonary / Respiratory Diseases, Other
Age Range:Any
Start Date:December 26, 2017
End Date:August 31, 2022

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Children's Respiratory and Environmental Workgroup (CREW) Phase II

The environment during the prenatal period and in early life is a major contributor to the
risk of developing childhood asthma. Birth cohort studies from single research centers have
identified several factors that affect the risk for developing childhood asthma, including
being exposed in early life to allergens, pollutants, viruses and bacteria, and psychosocial
stress. Despite such advances, further progress in understanding the root causes of asthma
have been hampered by the small size of previous studies, which makes it difficult to: 1)
identify asthma risk factors with certainty, 2) know how environmental factors across the
United States (U.S.) affect asthma, and 3) whether there are critical ages when pregnant
mothers, infants and young children are particularly susceptible to these influences.
Furthermore, different research groups tend to use different methods to study asthma, making
it difficult to either compare or pool findings. One other challenge is that there are
several types (i.e. phenotypes, endotypes) of childhood asthma, but these are poorly
understood. To help overcome these challenges, investigators leading 12 asthma birth cohorts
across the U.S. have established the Children's Respiratory Research Workgroup (CREW)
consortium. CREW proposes to identify specific types of childhood asthma, develop an
understanding of what early life environmental influences cause these different types of
asthma and when, and identify targets for future efforts aimed at preventing childhood

CREW is an NIH-funded project consisting of 12 individual U.S. birth cohorts and two
scientific centers working together to identify phenotypes and causes of childhood asthma.
CREW will include data from a large number of children (over 9,000 at birth, 6,000-7,000 who
are still being followed, and at least 5,667 expected to enroll in CREW) and their families,
with broad diversity in terms of ethnicity, family characteristics, neighborhoods and
geographic locations. One of the primary goals of CREW is to put together sets of data and
samples of participating cohorts to identify phenotypes of childhood asthma (i.e. specific
subtypes of asthma that can be distinguished by clinical features such as natural history,
triggers, exacerbation frequency, concurrent allergies, lung function, sex, etc). As we
obtain mechanistic insights about personal and early life risk factors, we will connect
asthma phenotypes with underlying causes and pathogenic mechanisms to define endotypes of
childhood asthma.

Inclusion Criteria:

1. Participant and/or parent guardian must be able to understand and provide informed
consent or assent (if required).

2. Participation in one of the 12 cohorts that make up CREW.

Exclusion Criteria:

1. Inability or unwillingness of a participant to give informed consent or assent (if
required) or comply with study protocol.

2. Past or current medical problems or findings from physical examination or laboratory
testing which, in the opinion of the investigator or designee, may pose additional
risks from participation in the study, may interfere with the participant's ability to
comply with study requirements or that may impact the quality or interpretation of the
data obtained from the study.
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Principal Investigator: Christine Johnson, MD
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3333 Burnet Avenue # Mlc3008
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Phone: 212-305-6270
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