Children's Respiratory and Environmental Workgroup



Status:Enrolling by invitation
Conditions:Allergy, Allergy, Asthma, Healthy Studies
Therapuetic Areas:Otolaryngology, Pulmonary / Respiratory Diseases, Other
Healthy:No
Age Range:Any
Updated:2/22/2019
Start Date:December 26, 2017
End Date:August 31, 2022

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Children's Respiratory and Environmental Workgroup (CREW) Phase II

The environment during the prenatal period and in early life is a major contributor to the
risk of developing childhood asthma. Birth cohort studies from single research centers have
identified several factors that affect the risk for developing childhood asthma, including
being exposed in early life to allergens, pollutants, viruses and bacteria, and psychosocial
stress. Despite such advances, further progress in understanding the root causes of asthma
have been hampered by the small size of previous studies, which makes it difficult to: 1)
identify asthma risk factors with certainty, 2) know how environmental factors across the
United States (U.S.) affect asthma, and 3) whether there are critical ages when pregnant
mothers, infants and young children are particularly susceptible to these influences.
Furthermore, different research groups tend to use different methods to study asthma, making
it difficult to either compare or pool findings. One other challenge is that there are
several types (i.e. phenotypes, endotypes) of childhood asthma, but these are poorly
understood. To help overcome these challenges, investigators leading 12 asthma birth cohorts
across the U.S. have established the Children's Respiratory Research Workgroup (CREW)
consortium. CREW proposes to identify specific types of childhood asthma, develop an
understanding of what early life environmental influences cause these different types of
asthma and when, and identify targets for future efforts aimed at preventing childhood
asthma.

CREW is an NIH-funded project consisting of 12 individual U.S. birth cohorts and two
scientific centers working together to identify phenotypes and causes of childhood asthma.
CREW will include data from a large number of children (over 9,000 at birth, 6,000-7,000 who
are still being followed, and at least 5,667 expected to enroll in CREW) and their families,
with broad diversity in terms of ethnicity, family characteristics, neighborhoods and
geographic locations. One of the primary goals of CREW is to put together sets of data and
samples of participating cohorts to identify phenotypes of childhood asthma (i.e. specific
subtypes of asthma that can be distinguished by clinical features such as natural history,
triggers, exacerbation frequency, concurrent allergies, lung function, sex, etc). As we
obtain mechanistic insights about personal and early life risk factors, we will connect
asthma phenotypes with underlying causes and pathogenic mechanisms to define endotypes of
childhood asthma.

Inclusion Criteria:

1. Participant and/or parent guardian must be able to understand and provide informed
consent or assent (if required).

2. Participation in one of the 12 cohorts that make up CREW.

Exclusion Criteria:

1. Inability or unwillingness of a participant to give informed consent or assent (if
required) or comply with study protocol.

2. Past or current medical problems or findings from physical examination or laboratory
testing which, in the opinion of the investigator or designee, may pose additional
risks from participation in the study, may interfere with the participant's ability to
comply with study requirements or that may impact the quality or interpretation of the
data obtained from the study.
We found this trial at
11
sites
Marshfield, Wisconsin 54449
Principal Investigator: Casper Bendixsen, MD
Phone: 715-221-7150
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3400 N Charles St
Baltimore, Maryland 21205
410-516-8000
Principal Investigator: Robert Wood, MD
Phone: 410-614-3525
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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Baltimore, MD
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75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Principal Investigator: Diane Gold, MD
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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72 East Concord Street
Boston, Massachusetts 02118
(617) 638-5300
Principal Investigator: George O'Connor, MD
Phone: 617-414-3294
Boston University School of Medicine A leader in medical education and research, Boston University School...
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3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
 1-513-636-4200 
Principal Investigator: Patrick Ryan, MD
Phone: 513-803-1651
Cincinnati Children's Hospital Medical Center Patients and families from across the region and around the...
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1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Principal Investigator: Tina Hartert, MD/MPH
Phone: 615-875-7448
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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Detroit, Michigan 48202
Principal Investigator: Christine Johnson, MD
Phone: 313-874-7390
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Detroit, MI
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Madison, Wisconsin 53705
Principal Investigator: Daniel Jackson, MD
Phone: 608-263-8544
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Madison, WI
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630 W 168th St
New York, New York
212-305-2862
Principal Investigator: Meyer Kattan, MD
Phone: 212-305-6270
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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Saint Louis, Missouri 63110
Principal Investigator: Leonard Bacharier, MD
Phone: 314-286-1290
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Saint Louis, MO
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Tucson, Arizona 85721
(520) 621-2211
Principal Investigator: Anne Wright, PhD
Phone: 520-626-7939
University of Arizona The University of Arizona is a premier, public research university. Established in...
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