ACT34-CMI -- Adult Autologous CD34+ Stem Cells



Status:Completed
Conditions:Angina, Peripheral Vascular Disease, Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:21 - 80
Updated:10/22/2017
Start Date:March 2006
End Date:March 2009

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A Double-blind, Prospective, Randomized, Placebo-controlled Study to Determine the Tolerability, Efficacy, Safety, and Dose Range of Intramyocardial Injections of G-CSF Mobilized Auto--CD34+ Cells for Reduction of Angina Episodes in Patients With Refractory Chronic Myocardial Ischemia (ACT34-CMI)

The purpose of this study is to evaluate the efficacy and safety of intramyocardial
injections of adult stem cells in patients with refractory chronic myocardial ischemia.

This is a double-blind, prospective, randomized, placebo-controlled trial to determine the
tolerability, efficacy, safety and dose range of intramyocardial injections of adult
autologous CD34+ cells mobilized with granulocyte colony stimulating factor for the reduction
of angina episodes in patients with refractory chronic myocardial ischemia.

Inclusion Criteria:

- 21-80 years of age

- CCS functional class III or IV chronic refractory angina

- unsuitable for conventional revascularization

Exclusion Criteria:

- predominant congestive heart failure

- left ventricular ejection fraction of less than 25% at screening

- myocardial infarction within 60 days of treatment

- successful coronary revascularization within 6 months of study enrollment

- history of moderate to severe aortic stenosis or prosthetic aortic valve

- co-morbidity associated with life expectancy of less than 1 year
We found this trial at
26
sites
11100 Euclid Ave
Cleveland, Ohio 44106
(216) 844-1000
University Hospitals of Cleveland The history of University Hospitals Case Medical Center is linked to...
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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Boston, MA
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234 Goodman Dr
Cincinnati, Ohio 45229
(513) 584-1000
University of Cincinnati Medical Center Opening in 1823 as the country
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Cincinnati, OH
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Gainesville, Florida 32610
(352) 392-3261
University of Florida The University of Florida (UF) is a major, public, comprehensive, land-grant, research...
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Jacksonville, Florida
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Atlanta, Georgia 30342
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Birmingham, Alabama 35211
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Boston, Massachusetts 02135
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675 North Saint Clair Street
Chicago, Illinois 60611
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Chicago, IL
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1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
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Chicago, IL
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Cincinnati, Ohio 45219
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Ft. Lauderdale, Florida 33308
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Ft. Lauderdale, FL
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Iowa City, Iowa 52242
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Iowa City, IA
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La Jolla, CA
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Madison, Wisconsin 53792
(608) 263-2400
University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...
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Madison, WI
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5555 North Port Washington Road
Milwaukee, Wisconsin 53215
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Minneapolis, Minnesota 55407
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Minneapolis, MN
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New York, New York 10021
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New York, NY
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New York, New York 10032
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601 E Rollins St
Orlando, Florida 32803
(407) 303-5600
Florida Hospital Florida Hospital is one of the country
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Phoenix, Arizona 85006
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Phoenix, Arizona
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200 Lothrop St
Pittsburgh, Pennsylvania 15213
University of Pittsburgh Medical Center UPMC is one of the leading nonprofit health systems in...
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5300 Tallman Ave NW
Seattle, Washington 98122
(206) 782-2700
Swedish Medical Center Since 1910, Swedish has been the region's hallmark for excellence in health...
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Stanford, California 94305
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110 Irving St NW
Washington, District of Columbia 20010
(202) 877-7000
Washington Hosp Ctr MedStar Washington Hospital Center is a not-for-profit, 926-bed, major teaching and research...
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