Low VW Activity in Adolescent HMB



Status:Recruiting
Healthy:No
Age Range:Any - 21
Updated:1/17/2019
Start Date:January 5, 2017
End Date:November 2025
Contact:Lakshmi V Srivaths, MD
Email:lvsrivat@txch.org
Phone:832-822-4242

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Genotypic and Phenotypic Analysis of Adolescents With Heavy Menstrual Bleeding and Low Von Willebrand Activity

This is a research study for patients diagnosed with heavy menstrual bleeding (HMB) and low
Von Willebrand Factor (VWF). Menstruation, also known as a period, is the regular discharge
of blood and tissues from the uterus. HMB is having a heavier amount of discharge during
menstrual period. Low Von Willebrand Factor means that the participant has lower level of a
blood protein that is important for clotting of blood and so, the participant is at a higher
risk for bleeding.

The purpose of this project is to study the genetic differences of adolescent females with
HMB and low VWF activity and compare the genetic differences with their bleeding
manifestations, response to medications and outcome.

One hundred and twenty subjects will be enrolled. Adolescent females with heavy menstrual
bleeding (HMB) and low Von Willebrand Factor (VWF) will be recruited.

Data collection will occur from participant's medical records in regards to their low VWF
activity and HMB medical history.

Participants will be asked to complete symptom questionnaires in regards to their HMB.

A blood sample will be collected to analyze how many participants have the disease causing
sequence variation in the VWF gene and other genes affecting bleeding, clotting and blood
vessel biology and correlated with their bleeding history.

The blood sample will be deidentified and stored indefinitely for future research.

Inclusion Criteria:

- Post-menarchal females less than 21 years of age

- HMB defined as PBAC score greater than 100

- VWF:Activity more than or equal to 30 and less than or equal to 50 IU/dL x 2

- VWF: Activity /VWF:Ag ratio greater than or equal to 0.6

- Normal VW multimers, if performed

Exclusion Criteria:

- Post menarchal females age greater than or equal to 21 years

- VWF: Activity less than 30 or greater than 50 IU/dL consistently, type 2 or type 3 VWD

- Presence of other bleeding disorders (thrombocytopenia, platelet function defect,
coagulation factor deficiency, fibrinogen defect or deficiency)
We found this trial at
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1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
 1-513-636-4200 
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700 Childrens Drive
Columbus, Ohio 43205
(616) 722-2000
Nationwide Children's Hospital At Nationwide Children’s, we are creating the future of pediatric health care....
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2401 Gillham Rd
Kansas City, Missouri 64108
(816) 234-3000
Children's Mercy Hospital Children's Mercy Hospitals and Clinics continues redefining pediatric medicine throughout the Midwest...
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4200 Fifth Ave
Pittsburgh, Pennsylvania 15260
(412) 624-4141
University of Pittsburgh The University of Pittsburgh is a state-related research university, founded as the...
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Atlanta, Georgia 30322
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936 Delaware Avenue
Buffalo, New York 14209
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East Lansing, Michigan 48824
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Hackensack, New Jersey 07601
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6621 Fannin St
Houston, Texas 77030
(832) 824-1000
Texas Children's Hospital Texas Children's Hospital, located in Houston, Texas, is a not-for-profit organization whose...
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Rochester, New York 14621
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