Acoustic Stimulation for Seizure Suppression

1. To test the feasibility of wearing an earphone system delivering acoustic stimulation
during a night of sleep in adult epilepsy patients monitored in an inpatient unit.

2. To determine the acute physiological effects of low-frequency acoustic stimulation on
interictal epileptiform discharge (IED) frequency during NREM sleep in adult patients
with epilepsy in an ambulatory setting.

3. To determine the feasibility of applying low-frequency acoustic stimulation in a
long-term home setting in adult epilepsy patients with frequent nocturnal seizures.

Inclusion Criteria:

- 18-60 years old

- Able to provide informed consent

- MOCA ≥26

- Fluent in English

- Frequent nocturnal IEDs (≥ 10% of the sleep record)

- Monitored on the adult epilepsy monitoring unit (EMU, for Aim 1 only) Additional
inclusion criteria for Aim 3

- Frequent nocturnal seizures (≥1 per week)

Exclusion Criteria:

- Hearing impairment

- Diagnosis of a sleep disorder (sleep apnea, periodic limb movements of sleep, or other
medical conditions with frequent arousals)

- Psychoactive medication use (other than AEDs, for example SSRIs, antipsychotics, BDZ,
or stimulants)

- Seizures ≤ 24 hours prior to study.

- Alcohol or recreational drug use in the 24 hours prior to the study

- BMI ≥ 30

- MOCA <26

- History of recent travel across time zones within the 1 month prior to study
activities

- Shift work for 1 month prior to study activities Additional Exclusion Criteria for Aim
3

- No medication changes at least 1 month before study, and during 3 months of study
activities