Proprioception and Sensorimotor Control in Hereditary Sensory and Autonomic Neuropathy
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Neurology, Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 16 - 40 |
| Updated: | 12/26/2018 |
| Start Date: | November 2016 |
| End Date: | April 19, 2019 |
This project comprises three sets of physiological studies - testing eight specific
hypotheses - that will contribute new knowledge on proprioception and motor control in a
genetic disorder that affects specific components of the sensory nervous system.
I: To investigate the neurophysiological basis for disturbed motor control in Hereditary
sensory and autonomic neuropathy (HSAN) III II: To investigate the effects of enhancing
cutaneous feedback on motor control in HSAN III III: To investigate the cortical
representation of proprioceptive inputs in HSAN III
hypotheses - that will contribute new knowledge on proprioception and motor control in a
genetic disorder that affects specific components of the sensory nervous system.
I: To investigate the neurophysiological basis for disturbed motor control in Hereditary
sensory and autonomic neuropathy (HSAN) III II: To investigate the effects of enhancing
cutaneous feedback on motor control in HSAN III III: To investigate the cortical
representation of proprioceptive inputs in HSAN III
HSAN III patients (n=15) and healthy control subjects (n=15) will lay supine on an MRI bed
and a tungsten microelectrode inserted percutaneously into a muscle or cutaneous fascicle of
the right common peroneal nerve at the fibular head, according to standard techniques
employed by Prof Macefield. Neural activity will be acquired, RMS-processed (200 ms) and
analysed on computer. The subject's head will be tightly enclosed in a standard clinical
32-channel SENSE head coil and headphones will be provided to minimize noise and to allow
communication with the subject. The subject will be placed in the bore of a 3T whole-body
scanner for 60-90 minutes.
and a tungsten microelectrode inserted percutaneously into a muscle or cutaneous fascicle of
the right common peroneal nerve at the fibular head, according to standard techniques
employed by Prof Macefield. Neural activity will be acquired, RMS-processed (200 ms) and
analysed on computer. The subject's head will be tightly enclosed in a standard clinical
32-channel SENSE head coil and headphones will be provided to minimize noise and to allow
communication with the subject. The subject will be placed in the bore of a 3T whole-body
scanner for 60-90 minutes.
Inclusion Criteria:
- Confirmed genetic diagnosis of HSAN III will be recruited from the Dysautonomia Center
at NYU
Exclusion Criteria:
- homeless
- active drug or alcohol dependence
- evidence of neurological disorder or diabetes
- exposure to neurotoxic drugs that in the investigator's opinion may compromise results
- Pregnant women
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