EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)



Status:Recruiting
Conditions:Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:4/4/2019
Start Date:March 2, 2017
End Date:June 1, 2021
Contact:Boehringer Ingelheim Call Center
Email:clintriage.rdg@boehringer-ingelheim.com
Phone:1-800-243-0127

Use our guide to learn which trials are right for you!

A Phase III Randomised, Double-blind Trial to Evaluate Efficacy and Safety of Once Daily Empagliflozin 10 mg Compared to Placebo, in Patients With Chronic Heart Failure With Preserved Ejection Fraction (HFpEF)

The aim of the study is to evaluate efficacy and safety of empagliflozin versus placebo on
top of guideline-directed medical therapy in patients with heart failure with preserved
ejection fraction


Inclusion criteria:

- Male or female patient, age >= 18 years at screening. For Japan only: Age >=20 years
at screening

- Patients with chronic HF (Chronic Heart Failure) NYHA (New York Heart Association
classification) class II-IV and preserved EF (Ejection Fraction)(LVEF (Left
Ventricular Ejection Fraction) > 40 %) and elevated NT-proBNP (N-terminal of the
prohormone brain natriuretic peptide) > 300 pg/ml for patients without AF, OR > 900
pg/ml for patients with AF, analysed at the Central laboratory at Visit 1

- Structural heart disease within 6 months prior to Visit 1, OR documented HHF
(Hospitalisation for Heart Failure) within 12 months prior to Visit 1

- Stable dose of oral diuretics, if prescribed

- Signed and dated written ICF (informed consent form)

- Further inclusion criteria apply

Exclusion criteria:

- Myocardial infarction, coronary artery bypass graft surgery or other major
cardiovascular surgery, stroke or TIA (Transient Ischaemic Attack) in past 90 days
prior to Visit 1

- Heart transplant recipient or listed for heart transplant

- Acute decompensated HF (Heart Failure)

- Systolic blood pressure (SBP) >= 180 mmHg at Visit 2.

- Symptomatic hypotension and/or a SBP < 100 mmHg

- Indication of liver disease,

- Impaired renal function, defined as eGFR (Estimated Glomerular Filtration Rate) < 20
mL/min/1.73 m2 (CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration
Equation))cr or requiring dialysis

- History of ketoacidosis

- Current use or prior use of a SGLT (Sodium-glucose co-transporter) -2 inhibitor or
combined SGLT-1 and 2 inhibitor

- Currently enrolled in another investigational device or drug trial

- Known allergy or hypersensitivity to empagliflozin or other SGLT-2 inhibitors

- Women who are pregnant, nursing, or who plan to become pregnant while in the trial

- Further exclusion criteria may apply
We found this trial at
118
sites
8051 Sudley Road
Manassas, Virginia 20109
Phone: +001 (703) 335-8750
?
mi
from
Manassas, VA
Click here to add this to my saved trials
860 Peachwood Drive
DeLand, Florida 32720
(386) 740-0770
Phone: +001 (386) 785-2400
Site Overview Avail Clinical Research is a renowned and experienced clinical research site conducting Phase...
?
mi
from
DeLand, FL
Click here to add this to my saved trials
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
Phone: +001 (617) 726-9554
?
mi
from
Boston, MA
Click here to add this to my saved trials
Chapel Hill, North Carolina 27599
(919) 962-2211
Phone: +001 (919) 843-5223
University of North Carolina at Chapel Hill Carolina’s vibrant people and programs attest to the...
?
mi
from
Chapel Hill, NC
Click here to add this to my saved trials
5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
Phone: +001 (773) 702-9396
University of Chicago One of the world's premier academic and research institutions, the University of...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
304 Northeast 1st Street
Chiefland, Florida 32626
Phone: +001 (352) 490-4816
?
mi
from
Chiefland, FL
Click here to add this to my saved trials
3500 Camp Bowie Boulevard
Fort Worth, Texas 76107
Phone: +001 (817) 735-2054
?
mi
from
Fort Worth, TX
Click here to add this to my saved trials
301 University Blvd
Galveston, Texas 77555
(409) 772-1011
Phone: +001 (409) 772-9835
University of Texas Medical Branch Established in 1891 as the University of Texas Medical Department,...
?
mi
from
Galveston, TX
Click here to add this to my saved trials
4085 University Blvd S # 1
Jacksonville, Florida 32216
Phone: +001 (904) 730-0101
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
11701 San Jose Blvd # 32
Jacksonville, Florida 32223
Phone: +001 (904) 854-1354
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
24 Sturtevant St
Orlando, Florida 32806
Phone: +001 (407) 351-5384
?
mi
from
Orlando, FL
Click here to add this to my saved trials
4202 E Fowler Ave
Tampa, Florida 33620
(813) 974-2011
Phone: +001 (813) 259-8543
University of South Florida The University of South Florida is a high-impact, global research university...
?
mi
from
Tampa, FL
Click here to add this to my saved trials
Albany, New York 12208
Phone: +001 (518) 292-6077
?
mi
from
Albany, NY
Click here to add this to my saved trials
Alexandria, Louisiana 71301
Phone: +001 (318) 473-4613
?
mi
from
Alexandria, LA
Click here to add this to my saved trials
1501 West Chisholm Street
Alpena, Michigan 49707
Phone: +001 (989) 340-2091
?
mi
from
Alpena, MI
Click here to add this to my saved trials
Anniston, Alabama 36207
Phone: +001 (256) 236-0055-x101
?
mi
from
Anniston, AL
Click here to add this to my saved trials
Arlington Heights, Illinois 60005
Phone: +001 (847) 483-0690
?
mi
from
Arlington Heights, IL
Click here to add this to my saved trials
Asheville, North Carolina 28802
Phone: +001 (828) 274-6001-x48463
?
mi
from
Asheville, NC
Click here to add this to my saved trials
80 Jesse Hill Junior Drive Southeast
Atlanta, Georgia 30303
Phone: +001 (404) 616-0121
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Augusta, Georgia 30912
Phone: +001 (706) 721-4997
?
mi
from
Augusta, GA
Click here to add this to my saved trials
Aurora, Colorado 80012
Phone: +001 (303) 750-0822
?
mi
from
Aurora, CO
Click here to add this to my saved trials
Austin, Texas 78705
Phone: +001 (512) 324-3434
?
mi
from
Austin, TX
Click here to add this to my saved trials
2401 Avenida Lainez
Bahia Blanca, 8000
Phone: +54 291 4593600 ext360/307/362
?
mi
from
Bahia Blanca,
Click here to add this to my saved trials
Beltsville, Maryland 20705
Phone: +001 (301) 595-0356
?
mi
from
Beltsville, MD
Click here to add this to my saved trials
Billings, Montana 59101
Phone: +001 (406) 238-2500
?
mi
from
Billings, MT
Click here to add this to my saved trials
3000 Northwest Boca Raton Boulevard
Boca Raton, Florida 33431
Phone: +001 (561) 756-8206
?
mi
from
Boca Raton, FL
Click here to add this to my saved trials
950 Stoneridge Drive
Bozeman, Montana 59718
Phone: +001 (406) 585-2444
?
mi
from
Bozeman, MT
Click here to add this to my saved trials
Bridgewater, New Jersey
Phone: +001 (908) 864-4027
?
mi
from
Bridgewater, NJ
Click here to add this to my saved trials
1461 Astor Avenue
Bronx, New York 10469
Phone: +001 (718) 655-1060
?
mi
from
Bronx, NY
Click here to add this to my saved trials
1234 Huffman Mill Road
Burlington, North Carolina 27215
Phone: +001 (336) 538-2381
?
mi
from
Burlington, NC
Click here to add this to my saved trials
Charleston, South Carolina 29403
Phone: +001 (843) 792-1414
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Charlotte, North Carolina 28204
Phone: +001 (704) 264-1400
?
mi
from
Charlotte, NC
Click here to add this to my saved trials
3091 William Street
Cheektowaga, New York 14227
Phone: +001 (716) 835-2966
?
mi
from
Cheektowaga, NY
Click here to add this to my saved trials
1720 East Hundred Road
Chester, Virginia 23836
Phone: +001 (804) 530-5178
?
mi
from
Chester, VA
Click here to add this to my saved trials
Clearwater, Florida 33756
Phone: +001 (727) 734-6533
?
mi
from
Clearwater, FL
Click here to add this to my saved trials
Cleveland, Ohio 44106
Phone: +001 (216) 421-3098
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
10710 Charter Drive
Columbia, Maryland 21044
Phone: +001 (443) 531-1400
?
mi
from
Columbia, MD
Click here to add this to my saved trials
Columbia, South Carolina 29203
Phone: +001 (803) 434-3800
?
mi
from
Columbia, SC
Click here to add this to my saved trials
1801 Inwood Rd
Dallas, Texas 75390
(214) 645-3300
Phone: +001 (214) 645-2727
University of Texas Southwestern Medical Center UT Southwestern is an academic medical center, world-renowned for...
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Dallas, Texas 75226
Phone: +001 (214) 820-7997
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Dallas, Texas 75226
Phone: +001 (214) 820-2273
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Des Moines, Iowa 50314
Phone: +001 (515) 235-5000
?
mi
from
Des Moines, IA
Click here to add this to my saved trials
Doylestown, Pennsylvania 18901
Phone: +001 (215) 345-6050-x246
?
mi
from
Doylestown, PA
Click here to add this to my saved trials
Elizabethtown, Kentucky 42701
Phone: +001 (270) 765-5921
?
mi
from
Elizabethtown, KY
Click here to add this to my saved trials
Elkhart, Indiana 46541
Phone: +001 (574) 522-0337
?
mi
from
Elkhart, IN
Click here to add this to my saved trials
Elmhurst, Illinois 60126
Phone: +001 (630) 527-2730
?
mi
from
Elmhurst, IL
Click here to add this to my saved trials
Farmington, Utah 84025
Phone: +001 (801) 261-2000
?
mi
from
Farmington, UT
Click here to add this to my saved trials
Fresno, California 93721
Phone: +001 (559) 228-5325
?
mi
from
Fresno, CA
Click here to add this to my saved trials
Germantown, Tennessee 38138
Phone: +001 (901) 271-1000
?
mi
from
Germantown, TN
Click here to add this to my saved trials
Grand Island, Nebraska 68803
Phone: +001 (402) 489-6555
?
mi
from
Grand Island, NE
Click here to add this to my saved trials
780 Main Street
Great Barrington, Massachusetts 01230
Phone: +001 (561) 756-8206
?
mi
from
Great Barrington, MA
Click here to add this to my saved trials
Houston, Texas 77094
Phone: +001 (281) 392-3401
?
mi
from
Houston, TX
Click here to add this to my saved trials
Houston, Texas 77030
Phone: +001 (773) 776-9500
?
mi
from
Houston, TX
Click here to add this to my saved trials
Huntsville, Alabama 35801
Phone: +001 (256) 519-8472
?
mi
from
Huntsville, AL
Click here to add this to my saved trials
5330 East Stop 11 Road
Indianapolis, Indiana 46237
Phone: +001 (317) 893-1712
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
Inverness, Florida 34452
Phone: +001 (352) 341-2100
?
mi
from
Inverness, FL
Click here to add this to my saved trials
Jackson, Mississippi 39216
Phone: +001 (601) 982-7850
?
mi
from
Jackson, MS
Click here to add this to my saved trials
327 Summar Drive
Jackson, Tennessee 38301
Phone: +001 (731) 423-8200
?
mi
from
Jackson, TN
Click here to add this to my saved trials
Jersey Shore, Pennsylvania 17740
Phone: +001 (570) 398-1800
?
mi
from
Jersey Shore, PA
Click here to add this to my saved trials
Johnstown, Pennsylvania 15905
Phone: +001 (814) 410-1250
?
mi
from
Johnstown, PA
Click here to add this to my saved trials
4401 Wornall Rd
Kansas City, Missouri 64111
(816) 932-2000
Phone: +001 (816) 932-5478
Saint Luke's Hospital, Kansas City Saint Luke's Hospital is a not-for-profit tertiary referral center committed...
?
mi
from
Kansas City, MO
Click here to add this to my saved trials
5565 Grossmont Center Drive
La Mesa, California 91492
Phone: +001 (619) 462-9353
?
mi
from
La Mesa, CA
Click here to add this to my saved trials
8860 Center Drive
La Mesa, California 91942
Phone: +001 (619) 229-1995
?
mi
from
La Mesa, CA
Click here to add this to my saved trials
Las Vegas, Nevada 89102
Phone: +001 (702) 826-2795
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
Lawrenceville, Georgia 30046
Phone: +001 (678) 430-3110
?
mi
from
Lawrenceville, GA
Click here to add this to my saved trials
Lewiston, Maine 04240
Phone: +001 (207) 782-9835-x112
?
mi
from
Lewiston, ME
Click here to add this to my saved trials
Littleton, Colorado 80120
Phone: +001 (303) 715-2210
?
mi
from
Littleton, CO
Click here to add this to my saved trials
Long Beach, California 90807
Phone: +001 (562) 595-9366
?
mi
from
Long Beach, CA
Click here to add this to my saved trials
6420 Dutchmans Parkway
Louisville, Kentucky 40205
Phone: +001 (502) 891-8300
?
mi
from
Louisville, KY
Click here to add this to my saved trials
Madison, Wisconsin 53713
Phone: +001 (434) 982-1058
?
mi
from
Madison, WI
Click here to add this to my saved trials
1040 Delaware Avenue
Marion, Ohio 43302
Phone: +001 (740) 383-7039
?
mi
from
Marion, OH
Click here to add this to my saved trials
Marshfield, Wisconsin 54449
Phone: +001 (715) 387-5845
?
mi
from
Marshfield, WI
Click here to add this to my saved trials
424 East Yosemite Avenue
Merced, California 95340
Phone: +001 (209) 723-6882
?
mi
from
Merced, CA
Click here to add this to my saved trials
Miami, Florida 33173
Phone: +001 (305) 275-8808
?
mi
from
Miami, FL
Click here to add this to my saved trials
Monroe, Louisiana 71203
Phone: +001 (318) 737-1098
?
mi
from
Monroe, LA
Click here to add this to my saved trials
1983 Marcus Avenue
New Hyde Park, New York 11042
Phone: +001 (516) 627-2121
?
mi
from
New Hyde Park, NY
Click here to add this to my saved trials
New Orleans, Louisiana 70112
Phone: +001 (504) 998-6256
?
mi
from
New Orleans, LA
Click here to add this to my saved trials
New Orleans, Louisiana 70112
Phone: +001 (504) 412-1520
?
mi
from
New Orleans, LA
Click here to add this to my saved trials
New York, New York 10025
Phone: +001 (212) 427-1540
?
mi
from
New York, NY
Click here to add this to my saved trials
1787 Madison Avenue
New York, New York 10035
Phone: +001 (212) 348-9400
?
mi
from
New York, NY
Click here to add this to my saved trials
North Chicago, Illinois 60064
Phone: +001 (847) 688-1900-x82001
?
mi
from
North Chicago, IL
Click here to add this to my saved trials
Northridge, California 91325
Phone: +001 (818) 678-4900
?
mi
from
Northridge, CA
Click here to add this to my saved trials
5200 East Interstate 240 Service Road
Oklahoma City, Oklahoma 73135
Phone: +001 (405) 628-6865
?
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
Orange, California 92868
Phone: +001 (714) 456-5376
?
mi
from
Orange, CA
Click here to add this to my saved trials
Ormond Beach, Florida 32174
Phone: +001 (386) 677-0525
?
mi
from
Ormond Beach, FL
Click here to add this to my saved trials
Owensboro, Kentucky 42303
Phone: +001 (270) 691 1827
?
mi
from
Owensboro, KY
Click here to add this to my saved trials
Oxon Hill, Maryland 20745
Phone: +001 (301) 839-2008
?
mi
from
Oxon Hill, MD
Click here to add this to my saved trials
11111 South 84th Street
Papillion, Nebraska 68046
Phone: +001 (402) 592-0077
?
mi
from
Papillion, NE
Click here to add this to my saved trials
416 Connable Avenue
Petoskey, Michigan 49770
Phone: +001 (231) 487-9185
?
mi
from
Petoskey, MI
Click here to add this to my saved trials
4700 Alliance Boulevard
Plano, Texas 75024
Phone: +001 (469) 800-6300
?
mi
from
Plano, TX
Click here to add this to my saved trials
1100 Reid Parkway
Richmond, Indiana 47374
Phone: +001 (765) 962-1337
?
mi
from
Richmond, IN
Click here to add this to my saved trials
401 North 11th Street
Richmond, Virginia 23219
Phone: +001 (804) 828-2161
?
mi
from
Richmond, VA
Click here to add this to my saved trials
Riverside, California 92506
Phone: +001 (951) 378-7754
?
mi
from
Riverside, CA
Click here to add this to my saved trials
Roanoke, Virginia 24014
Phone: +001 (540) 981-2105
?
mi
from
Roanoke, VA
Click here to add this to my saved trials
Rockford, Illinois
Phone: +001 (815) 395-9181
?
mi
from
Rockford, IL
Click here to add this to my saved trials
234-36 Merrick Boulevard
Rosedale, New York 11422
Phone: +001 (718) 949-9400
?
mi
from
Rosedale, NY
Click here to add this to my saved trials
Saint Louis, Missouri 63110
Phone: +001 (314) 268-5293
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials
Saint Louis, Missouri 63136
Phone: +001 (314) 741-0911
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials
640 Jackson Street
Saint Paul, Minnesota 55101
Phone: +001 (651) 254-4139
?
mi
from
Saint Paul, MN
Click here to add this to my saved trials
1970 Roanoke Boulevard
Salem, Virginia 24153
Phone: +001 (540) 982-2463-x2970
?
mi
from
Salem, VA
Click here to add this to my saved trials
San Antonio, Texas 78229
Phone: +001 (210) 567-6691
?
mi
from
San Antonio, TX
Click here to add this to my saved trials