Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers

Conditions:Smoking Cessation, Tobacco Consumers
Therapuetic Areas:Pulmonary / Respiratory Diseases
Age Range:18 - 25
Start Date:January 2017
End Date:April 2019
Contact:Rachel Kozink, M.S.

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The purpose of this study is to evaluate reactions to, and choices to self-administer,
cigarette smoke with varying nicotine content among low-frequency, non-dependent
adolescent/young adult smokers between the ages of 18-25 years.

Participants will undergo three sessions in which their reactions to fixed doses of smoke
from investigational cigarettes with three different nicotine contents (15.8 mg/gram of
tobacco, 2.5 mg/g, and .4 mg/g) will be assessed. Following the third fixed-dose session,
participants will return to the lab to choose one of the cigarettes to self-administer.

Inclusion Criteria:

- generally healthy

- between the ages of 18-25

- use nicotine or tobacco products between 1-15 days/month for at least 6 months

- smokes at least 10 cigarettes/month

- no unstable or significant medical or psychiatric conditions

- breath alcohol value=0.000

- able to provide contact information for two individuals who can corroborate smoking

Exclusion Criteria:

- use of illegal drugs as measured by urine drug screen (excluding THC)

- serious quit attempt in the past 3 months

- plans to quit smoking in the next 2 months

- current use of nicotine replacement therapy or other tobacco cessation products

- inability to attend all required experimental sessions

- blood pressure >160/100 mmHg

- pregnant, trying to become pregnant, or breastfeeding
We found this trial at
2301 Erwin Rd
Durham, North Carolina 27710
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
Durham, NC
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