Let's Play! Healthy Kids After Cancer



Status:Completed
Conditions:Obesity Weight Loss, Blood Cancer
Therapuetic Areas:Endocrinology, Oncology
Healthy:No
Age Range:4 - 10
Updated:12/15/2018
Start Date:February 2015
End Date:October 2016

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Healthy Kids After Cancer: A Physical Activity and Nutrition Intervention

This pilot study will evaluate the feasibility, acceptability, and potential efficacy of a
parent-targeted, phone-based program to prevent unhealthy weight gain and improve biomarkers
of oxidative stress and inflammation among childhood acute lymphoblastic leukemia survivors.

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, accounting for 25% of
all childhood malignancies. Treatment of childhood ALL has a high success rate, with
long-term event-free survival of >85%. Treatment success, however, has not come without cost.
Recognition of long-term health problems related to childhood cancer therapies is growing.
Both during and after therapy, children treated for ALL are at risk for fatigue, reduced
physical activity, poor dietary intake, and excessive weight gain, which are driven by
physiological (chemotherapy-induced) changes and social (home/environmental) factors. The
goals of this pilot study are to evaluate the feasibility, acceptability, and potential
efficacy of a parent-targeted, phone-delivered nutrition and physical activity program to
prevent unhealthy weight gain among 60 childhood ALL survivors, 4-10 years of age.
Participants will be randomly assigned to either the phone-delivered parent-targeted
nutrition and physical activity intervention or a standard-of-care control group.
Intervention success will be benchmarked by changes in key weight-related behaviors (physical
activity and dietary intake) over the 6-month trial, and initial impact of the intervention
on biomarkers of inflammation and oxidative stress, fatigue, and body composition will be
examined.

Inclusion Criteria:

- Between 4.0 years and < 11.0 years of age at the time of recruitment

- Previously diagnosed of ALL and currently in remission

- Between 1-5 years post completion of chemotherapy

- BMI ≥ 85 percentile for age and sex (overweight or obese) OR at risk for obesity (BMI
between the 50th and 85th percentile and at least one overweight parent (BMI ≥ 25
kg/m2)

Exclusion Criteria:

- History of cranial radiation therapy

- History of bone marrow transplant

- History of relapse of ALL

- Diagnosis of Down's Syndrome

- Comorbidities of obesity that require immediate subspecialist referral

- Significant pulmonary, cardiovascular, orthopedic, or musculoskeletal problems that
would, in their oncologist's judgment, limit their ability to participate in physical
activity

- Significant psychiatric or neurologic disorders that would impair compliance with
study protocol

- Current participation in a weight-loss program
We found this trial at
3
sites
Minneapolis, Minnesota 55404
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262 Danny Thomas Pl
Memphis, Tennessee 38105
(901) 495-3300
St. Jude Children's Research Hospital St. Jude is unlike any other pediatric treatment and research...
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Memphis, TN
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425 E River Pkwy # 754
Minneapolis, Minnesota 55455
612-624-2620
Masonic Cancer Center at University of Minnesota The Masonic Cancer Center was founded in 1991....
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Minneapolis, MN
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