Measurement of Glucose Metabolism in Humans: Effect of Recurrent Hypoglycemia on Hypothalamic GABA



Status:Not yet recruiting
Conditions:Healthy Studies, Endocrine, Diabetes
Therapuetic Areas:Endocrinology, Other
Healthy:No
Age Range:18 - 65
Updated:10/17/2018
Start Date:October 2019
End Date:July 2020
Contact:Anjali Kumar, PA-C
Email:studydiabetes@umn.edu
Phone:612-301-7040

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Measurement of Glucose Metabolism in Humans Using Magnetic Resonance at 7 Tesla: Effect of Recurrent Hypoglycemia on Hypothalamic GABA

You are invited to participate in a study designed to investigate the effects of diabetes
mellitus, high and low glucose, and high blood insulin on the brain. You were selected as a
possible participant because you fit into one of the following categories. a) you are either
healthy and competent, are not pregnant and you have no known medical disease and therefore
your glucose metabolism will be typical of a normal person, or b) you have diabetes.

Glucose is a major fuel for most organs in the human body, particularly the brain. How and
where the body uses glucose is regulated by a number of hormones, for instance insulin and
glucagon. In a number of diseases, in particular diabetes mellitus, the glucose supply to the
brain may be different than normal, which may be a cause for reduced glucose awareness.

The purpose of this study is to determine the effects of altered glucose metabolism on the
brain. For example, patients with long duration diabetes mellitus lose their ability to
secrete the hormones necessary to protect them against hypoglycemia, which may be due to
alterations in glucose availability to the human brain.

To measure these effects, we will use intravenous infusions of glucose and insulin.

Inclusion Criteria:

- well controlled type 1 diabetes (hemoglobin A1c <7.5%)

- age 18-65

- healthy controls

Exclusion Criteria:

- history of stroke, seizures, neurosurgical procedures, or arrhythmias

- use of drugs that can alter GABA metabolism (such as benzodiazepines).

- Subjects must also meet requirements for a study in the magnet, which includes weight
less than 300 lbs and the absence of metallic substances in their body.
We found this trial at
1
site
Minneapolis, Minnesota 55455
(612) 625-5000
Principal Investigator: Elizabeth Seaquist, MD
Phone: 612-301-7040
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
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mi
from
Minneapolis, MN
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