A Study of LY3202626 on Disease Progression in Participants With Mild Alzheimer's Disease Dementia



Status:Terminated
Conditions:Alzheimer Disease, Neurology
Therapuetic Areas:Neurology
Healthy:No
Age Range:55 - 85
Updated:8/25/2018
Start Date:June 16, 2016
End Date:July 2, 2018

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Effect of LY3202626 on Alzheimer's Disease Progression as Measured by Cerebral ¹⁸F-AV-1451 Tau-PET in Mild Alzheimer's Disease Dementia

The main purpose of this study is to evaluate the safety and the effect on brain tau of the
study drug LY3202626 in participants with mild Alzheimer's disease (AD) dementia.


Inclusion Criteria:

- Present with mild AD dementia based on the National Institute on Aging (NIA) and the
Alzheimer's Association (AA) disease diagnostic criteria as determined by a qualified
clinician approved by the Sponsor or designee.

- Mini-Mental State Examination score of 20 to 26 inclusive at screening visit.

- Has a florbetapir PET scan consistent with the presence of amyloid pathology at
screening.

Exclusion Criteria:

- Significant neurological disease affecting the central nervous system (CNS), other
than AD, that may affect cognition or ability to complete the study, including but not
limited to, other dementias, serious infection of the brain, Parkinson's disease,
multiple concussions, or epilepsy or recurrent seizures (except febrile childhood
seizures).

- Ocular pathology that significantly limits ability to reliably evaluate vision or the
retina.

- Use of strong inducers of cytochrome P450 3A (CYP3A).

- Sensitivity to florbetapir or ¹⁸F-AV-1451.

- Contraindication to MRI or PET or poor venous access for blood draws.
We found this trial at
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San Diego, California 92123
Principal Investigator: MICHAEL PLOPPER
Phone: 858-836-8355
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104 SE 1st Avenue
Ocala, Florida 34471
352-629-5800
Principal Investigator: John Nardandrea
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1709 S Rock Rd
Wichita, Kansas 67207
316-689-6629
Principal Investigator: Dwight St Clair
Phone: 316-462-0427
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Abington, Pennsylvania 19001
Principal Investigator: David Weisman
Phone: 215-957-9250
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47 New Scotland Ave
Albany, New York 12208
(518) 262-3125
Principal Investigator: David Hart
Phone: 518-459-8106
Albany Medical College Albany Medical Center is northeastern New York's only academic health sciences center...
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Allentown, Pennsylvania 18104
Principal Investigator: Paul Gross
Phone: 610-820-0342
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Amherst, New York 14226
Principal Investigator: Horace Capote
Phone: 716-250-2000
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733 North Broadway
Baltimore, Maryland 21205
(410) 955-3182
Principal Investigator: Paul Rosenberg
Phone: 410-550-9883
Johns Hopkins University School of Medicine Johns Hopkins Medicine (JHM), headquartered in Baltimore, Maryland, is...
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Bolivar, Missouri 65613
Principal Investigator: Curtis Schreiber
Phone: 417-327-3530
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Centerville, Ohio
Principal Investigator: Meenakshi Patel
Phone: 937-208-8298
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Charleston, South Carolina 29406
Principal Investigator: David Stickler
Phone: 843-725-5067
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Chesterfield, Missouri 63141
Principal Investigator: Siddharth Kaul
Phone: 636-220-1200
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Creve Coeur, Missouri 63141
Principal Investigator: Franco Sicuro
Phone: 314-298-0001
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Dallas, Texas 75219
Principal Investigator: Claudia Padilla
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Dayton, Ohio 45414
Principal Investigator: Joel Vandersluis
Phone: 937-224-8200
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3230 Eden Avenue
Dayton, Ohio 45417
Principal Investigator: Lawrence Goldstick
Phone: 937-535-5012
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Eatontown, New Jersey 07724
Principal Investigator: Mark Ornstein
Phone: 732-263-0101
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Fort Wayne, Indiana 46805
Principal Investigator: James Stevens
Phone: 260-436-2416
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Gainesville, Georgia 30501
Principal Investigator: Christopher Recknor
Phone: 678-928-6482
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Houston, Texas 77030
Principal Investigator: Bryan Spann
Phone: 713-441-1150
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Houston, Texas 77054
Principal Investigator: Paul Schulz
Phone: 713-486-0500
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340 W 10th St #6200
Indianapolis, Indiana 46202
(317) 274-3772
Principal Investigator: Martin Farlow
Phone: 317-936-7401
Indiana University School of Medicine With more than 2,000 students in 2013, the Indiana University...
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Irvine, California 92618
Principal Investigator: Elly Lee
Phone: 949-753-1663
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Jacksonville, Florida 32216
Principal Investigator: Nandita Jones
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Jenkintown, Pennsylvania 19046
Principal Investigator: Marvin Kalafer
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Kansas City, Missouri 64111
Principal Investigator: Stanley Fisher
Phone: 816-932-9897
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Las Vegas, Nevada 89113
Principal Investigator: Bharat Mocherla
Phone: 702-666-6066
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Melbourne, Florida 32940
Principal Investigator: Scott Franczek
Phone: 321-202-2720
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Miami, Florida 33175
Principal Investigator: Francisco Miranda
Phone: 305-226-3933
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Miami, Florida 33166
Principal Investigator: Elena Valor
Phone: 305-409-9079
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Miami, Florida 33176
Principal Investigator: Brad Herskowitz
Phone: 305-596-2080
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Monroe, New Jersey 08831
Principal Investigator: Jeffrey Greenberg
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New Port Richey, Florida 34652
Principal Investigator: Vikram Atit
Phone: 727-849-4131
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Newton, Massachusetts 02459
Principal Investigator: Paul Solomon
Phone: 617-699-6927
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Ocoee, Florida 34761
Principal Investigator: Kelly Taylor
Phone: 407-654-2724
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Sacramento, California 95816
Principal Investigator: Shawn Kile
Phone: 916-454-6850
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660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Principal Investigator: JOHN MORRIS
Phone: 314-286-2881
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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San Diego, California 92103
Principal Investigator: Stephen Thein
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45 Castro Street
San Francisco, California 94114
Principal Investigator: Alireza Atri
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Santa Ana, California 92705
Principal Investigator: John Duffy
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Sebastopol, California 95472
Principal Investigator: United States
Phone: 707-827-3593
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Shaker Heights, Ohio 44122
Principal Investigator: Deborah Gould
Phone: 216-295-6020
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120 Medical Boulevard
Spring Hill, Florida 34609
Principal Investigator: James Andersen
Phone: 352-597-8839
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Stamford, Connecticut 06905
Principal Investigator: Peter McAllister
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Tampa, Florida 33609
Principal Investigator: SUSAN STEEN
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Toms River, New Jersey 08755
Principal Investigator: Sanjiv Sharma
Phone: 732-341-9500
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Toms River, New Jersey 08755
Principal Investigator: Ashok Patel
Phone: 732-244-2299
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Topeka, Kansas 66606
Principal Investigator: Scott Teeter
Phone: 785-354-9591
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Wilmington, Delaware 19801
Principal Investigator: James Ellison
Phone: 302-320-6147
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