Sparsity-based Magnetic Resonance Imaging of Cardiac Arrhythmias



Status:Recruiting
Conditions:Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:10 - 85
Updated:12/22/2018
Start Date:September 29, 2017
End Date:September 2019
Contact:Gabriella Maranga
Email:Gabrielle.Maranga@nyumc.org

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The primary purpose of this study is to improve the quality of Magnetic Resonance Imaging in
patients with heart arrhythmia. Investigators will recruit 105 patients with arrhythmia and
30 control volunteers over 3 years and will use two arrhythmia-tolerant imaging methods for
diagnosis.

In the proposed research, investigators will extend conventional cardiac magnetic resonance
methods to enable the creation of high-quality cine CMR images in the presence of multiple
kinds of arrhythmia. Two arrhythmia-tolerant imaging methods will be adopted, which are
particularly useful in arrhythmia: 1) 3D imaging, which is useful for many purposes,
including "road mapping" of electrophysiology (EP) procedures, and 2) late gadolinium
enhancement (LGE), which is useful for delineating abnormal myocardium, including fibrotic
regions that can serve as sources of arrhythmias.

Inclusion Criteria for Arrhythmia Patients:

- Patients diagnosed with heart arrhythmia scheduled for routine clinical MRI
examinations).

- Patients scheduled for routine clinical MRI examinations who do not have a specific
known diagnosis of arrhythmia, but who may be found to have image degradation due to
arrhythmia during the CMR examination.

Inclusion Criteria for Controls:

- No history of heart arrhythmia.

Exclusion Criteria for Patients and Controls:

- Hemodynamic instability.

- Contraindications for MRI examinations (e.g., pacemakers or ferromagnetic vascular
clips).

- History of prior cardiovascular disease or significant risk factors:

- Diabetes, hypertension, smoking, and hyperlipidemia, etc.
We found this trial at
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550 1st Ave
New York, New York 10016
(212) 263-7300
Principal Investigator: Leon Axel, MD
New York University School of Medicine NYU School of Medicine has a proud history that...
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