Brain Ion Homeostasis, Lithium and Bipolar Disorder

Conditions:Healthy Studies, Psychiatric, Bipolar Disorder
Therapuetic Areas:Psychiatry / Psychology, Other
Age Range:18 - 45
Start Date:September 2015
End Date:September 2019
Contact:Steven Stork

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In this project, investigators intend to carry out the first simultaneous, in vivo, imaging
study of lithium content and sodium ion homeostasis in the brain of Bipolar Disorder (BPD)
patients under Lithium therapy.

The purpose of this study is to validate a new method for the measurement of the amount of
lithium (also known as lithium concentration) in the brain of subjects undergoing lithium
treatment for bipolar disorder. The method involves the use of Magnetic Resonance Imaging
(MRI) and Spectroscopy (MRS) techniques. These are non-invasive techniques, with no known
harmful effects, that allow investigators to measure the amount of lithium in an individual's
brain. There will be no contrast dye used in this study.

Inclusion Criteria:

- Psychiatrically stable patients (diagnosed according to the Diagnostic and Statistical
Manual, DSM-IV, criteria)

- On steady state serum lithium levels (0.8-1.2mEq/L)

Exclusion Criteria:

- Subjects who have a history of head trauma

- Subjects who have a contraindication for an MRI exam, including a claustrophobia,
surgical or vascular implants, pregnancy, pacemakers, neurostimulators, history of
metal in the eyes, and orthodontia or extensive bridgework (with have a particular
impact on gradient echo imaging).
We found this trial at
550 1st Ave
New York, New York 10016
(212) 263-7300
Phone: 212-263-0001
New York University School of Medicine NYU School of Medicine has a proud history that...
New York, NY
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