Arginine Feeding: a Novel Strategy to Improve Protein Metabolism in Cancer and the Response to Surgery
| Status: | Active, not recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 30 - Any |
| Updated: | 4/28/2018 |
| Start Date: | April 2009 |
| End Date: | February 2019 |
Muscle catabolism is a major problem in cancer patients undergoing surgery as it negatively
affects post-operative recovery. Recent evidence exists that protein metabolic changes are
already apparent in cancer before muscle wasting is being present. In line, patients with
breast cancer, generally characterized by a normal nutritional status, were recently found to
be arginine deficient. Arginine deficiency in cancer can be explained by: 1) Reduced arginine
availability, due to exhaustion of endogenous (muscle) sources of arginine 2) Enhanced
arginine catabolism, due to conversion of arginine by arginase, which is abundant in tumors.
Protein is the most important endogenous source of arginine. Arginine deficiency will lead to
a negative feedback loop in cachexia by promoting protein breakdown in an attempt to restore
plasma arginine levels. We hypothesize that pre-operative arginine supplementation in breast
cancer patients diminishes the occurrence of muscle wasting after surgery by 1) normalizing
arginine availability pre-operatively, resulting in conservation of protein, 2) diminishing
the catabolic effects of surgery by supplying exogenous arginine for the post-operative
response, 3) enhancing the anabolic capacity to feeding through supplying substrate for
protein synthesis.
affects post-operative recovery. Recent evidence exists that protein metabolic changes are
already apparent in cancer before muscle wasting is being present. In line, patients with
breast cancer, generally characterized by a normal nutritional status, were recently found to
be arginine deficient. Arginine deficiency in cancer can be explained by: 1) Reduced arginine
availability, due to exhaustion of endogenous (muscle) sources of arginine 2) Enhanced
arginine catabolism, due to conversion of arginine by arginase, which is abundant in tumors.
Protein is the most important endogenous source of arginine. Arginine deficiency will lead to
a negative feedback loop in cachexia by promoting protein breakdown in an attempt to restore
plasma arginine levels. We hypothesize that pre-operative arginine supplementation in breast
cancer patients diminishes the occurrence of muscle wasting after surgery by 1) normalizing
arginine availability pre-operatively, resulting in conservation of protein, 2) diminishing
the catabolic effects of surgery by supplying exogenous arginine for the post-operative
response, 3) enhancing the anabolic capacity to feeding through supplying substrate for
protein synthesis.
In the present proposal, the effects of surgery and cancer will be examined by comparing
subjects undergoing breast surgery because of malignancy vs. prophylactic reasons (aim 1).
Furthermore, the effects of one-week pre-operative protein feeding with or without enrichment
with arginine on post-operative protein metabolism (aim 2) will be investigated in the cancer
group. Variables of interest are: 1. Whole-body and skeletal muscle protein metabolism, whole
body arginine turnover and de-novo arginine production rate, and the anabolic capacity to
feeding(assessed by stable isotope methodology). 2. Body weight, muscle mass and functional
status, score for well-being (assessed by Profile of Mood State and Mini Mental State).
In the present study, we propose that a nutritional supplement that is high in protein
content and enhanced in arginine will be more effective than a typical commercial nutritional
supplement in diminishing the catabolic effects of surgery in subjects with cancer, thereby
optimizing their quality of life. If this is found to be the case, this would provide the
basis for reformulating the nutritional composition in accord with the effects of cancer and
surgery on protein metabolism.
subjects undergoing breast surgery because of malignancy vs. prophylactic reasons (aim 1).
Furthermore, the effects of one-week pre-operative protein feeding with or without enrichment
with arginine on post-operative protein metabolism (aim 2) will be investigated in the cancer
group. Variables of interest are: 1. Whole-body and skeletal muscle protein metabolism, whole
body arginine turnover and de-novo arginine production rate, and the anabolic capacity to
feeding(assessed by stable isotope methodology). 2. Body weight, muscle mass and functional
status, score for well-being (assessed by Profile of Mood State and Mini Mental State).
In the present study, we propose that a nutritional supplement that is high in protein
content and enhanced in arginine will be more effective than a typical commercial nutritional
supplement in diminishing the catabolic effects of surgery in subjects with cancer, thereby
optimizing their quality of life. If this is found to be the case, this would provide the
basis for reformulating the nutritional composition in accord with the effects of cancer and
surgery on protein metabolism.
Inclusion Criteria:
Cancer groups (for aims 1 and 2)
1. Recently diagnosed (up to 4 weeks prior to treatment for cancer) with stage I, II or
III invasive breast cancer
2. Undergoing mastectomy
3. Age greater than 30 years
4. Ability to sign informed consent
5. Good performance status defined by ECOG scale 0,1 or 2 (see CRF performance status)
Control group (for aim 1)
1. Age greater than 30 years
2. Undergoing prophylactic mastectomy
3. Ability to sign informed consent
4. Good performance status defined by ECOG scale 0,1 or 2 (see CRF performance status)
Exclusion Criteria:
All groups (aim 1 and 2)
1. Body weight loss of greater than 10% in the past 3 months
2. Previous anti-cancer therapy (e.g. chemotherapy or radiotherapy) or surgery less than
4 weeks prior to the experiment
3. Diagnosed diabetes type I or II
4. Untreated metabolic diseases including liver or renal disease
5. Any documented autoimmune disease
6. Use of corticosteroids, beta-antagonists or nitrovasodilators
7. Use of supplements enriched with amino acids
8. Presence of acute illness or metabolically unstable chronic illness
9. Unstable heart disease requiring therapy or recent myocardial infarction (less than 1
year)
10. Current alcohol or drug abuse (ETOH more than 2 servings per day)
11. Allergy/intolerance to any of the ingredients of the study products
12. Any other condition deemed by the PI and the study physician as exclusion or that
interferes with proper conduct of the study/ safety of the patient.
We found this trial at
1
site
529 West Markham Street
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
(501) 686-7000
University of Arkansas for Medical Sciences The University of Arkansas for Medical Sciences (UAMS) in...
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