A Safety and Efficacy Study of Farletuzumab in Subjects With Adenocarcinoma of the Lung



Status:Completed
Conditions:Lung Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:April 2011
End Date:November 2013

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Double-Blind, Placebo-Controlled, Study of the Safety and Efficacy of Farletuzumab in Combination With a Platinum Containing Doublet in Chemotherapy-Naїve Subjects With Stage IV Adenocarcinoma of the Lung

This randomized, placebo-controlled, multicenter study will test the hypothesis that
farletuzumab can add to the efficacy of a platinum containing doublet in Stage IV
adenocarcinoma of the lung.


Inclusion Criteria:

- Histologically or cytologically confirmed adenocarcinoma of the lung classified as
stage IV

- Confirmed folate receptor-alpha (FRA) expression by IHC

- Measurable disease with at least one unidimensionally measurable lesion according to
RECIST criteria version 1.1 by CT or MRI scans (CT or MRI scans must have been
performed within 30 days prior to the first dose of farletuzumab or placebo)

- Must have received no prior chemotherapy, radiation therapy or surgery with curative
intent for adenocarcinoma of the lung

Exclusion Criteria:

- Subjects who have had previous chemotherapy for adenocarcinoma of the lung

- Prior surgery with curative intent for adenocarcinoma of the lung

- Prior radiotherapy for adenocarcinoma of the lung. (Prior treatment with local
radiotherapy for symptom control [i.e., palliative radiation with non-curative
intent] is permitted)
We found this trial at
55
sites
Northwest Cancer Center
Sugar Land, Texas 77479
1345
mi
from 91732
Sugar Land, TX
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Center for Hematology Oncology
Boca Raton, Florida 33486
2311
mi
from 91732
Boca Raton, FL
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University of Texas Medical Branch
301 University Blvd
Galveston, Texas 77555
(409) 772-1011
University of Texas Medical Branch Established in 1891 as the University of Texas Medical Department,...
1399
mi
from 91732
Galveston, TX
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M.D. Anderson Cancer Center at Orlando
1400 South Orange Avenue
Orlando, Florida 32806
(407) 648-3800
M.D. Anderson Cancer Center at Orlando For more than twenty years, our cancer center has...
2184
mi
from 91732
Orlando, FL
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Christus Saint Frances, Cabrini Hospital, Cabrini Cancer Center
Alexandria, Louisiana 71301
1494
mi
from 91732
Alexandria, LA
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Texas Oncology, P.A. - Bedford
Bedford, Texas 76022
1203
mi
from 91732
Bedford, TX
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National Cancer Institute
Bethesda, Maryland
2277
mi
from 91732
Bethesda, MD
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St. Luke's Cancer Center Associates
Bethlehem, Pennsylvania 18015
2361
mi
from 91732
Bethlehem, PA
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Providence Health System
Beverly Hills, California 90210
22
mi
from 91732
Beverly Hills, CA
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University Hematology Oncology, Inc
Centralia, Illinois 62801
1630
mi
from 91732
Centralia, IL
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Ironwood Cancer and Research Center
Chandler, Arizona 85224
356
mi
from 91732
Chandler, AZ
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University of Chicago Medical Center
5841 S Maryland Ave
Chicago, Illinois 60637
(773) 702-1000
University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
1730
mi
from 91732
Chicago, IL
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Maryland Oncology Hematology PA
Columbia, Maryland 21044
2288
mi
from 91732
Columbia, MD
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Medical Specialists of the Palm Beaches
Deerfield Beach, Florida 33441
2312
mi
from 91732
Deerfield Beach, FL
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Rocky Mountain Cancer Centers, LLP
Denver, Colorado 80218
818
mi
from 91732
Denver, CO
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Englewood Hospital and Medical Center
350 Engle St
Englewood, New Jersey 07631
(201) 894-3000
Englewood Hospital and Medical Center Englewood Hospital was incorporated in 1888 as a non-profit, non-sectarian...
2433
mi
from 91732
Englewood, NJ
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Willamette Valley Cancer Institute/Research Ctr
Eugene, Oregon 97401
741
mi
from 91732
Eugene, OR
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Deaconess Clinic Downtown
Evansville, Indiana 47713
1715
mi
from 91732
Evansville, IN
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Virginia Cancer Specialists, PC
8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
2269
mi
from 91732
Fairfax, VA
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Detroit Clinical Research Center PC
Farmington Hills, Michigan 48334
1952
mi
from 91732
Farmington Hills, MI
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Broward General Medical Center
Fort Lauderdale, Florida 33316
2317
mi
from 91732
Fort Lauderdale, FL
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Cancer Care Associates of Fresno Medical Group Inc
Fresno, California 93720
216
mi
from 91732
Fresno, CA
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Gettysburg Cancer Center
Gettysburg, Pennsylvania 17325
2266
mi
from 91732
Gettysburg, PA
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Medical Oncology Hematology
Gilroy, California 95020
284
mi
from 91732
Gilroy, CA
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Arizona Center for Hematology Oncology
Glendale, Arizona 85306
336
mi
from 91732
Glendale, AZ
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Cancer TEAM Bellin Health
Green Bay, Wisconsin 54313
1746
mi
from 91732
Green Bay, WI
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California Cancer Care
Greenbrae, California 94904
368
mi
from 91732
Greenbrae, CA
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Kentucky Cancer Center
Hazard, Kentucky 41701
1955
mi
from 91732
Hazard, KY
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Houston Cancer Institute
1098 Hermann Drive
Houston, Texas 77055
1357
mi
from 91732
Houston, TX
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Queens Hospital Center
Jamaica, New York 11432
2444
mi
from 91732
Jamaica, NY
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Moores University of California San Diego Cancer Center
La Jolla, California 92093
95
mi
from 91732
La Jolla, CA
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Wilshire Medical Oncology Group
La Verne, California 91750
14
mi
from 91732
La Verne, CA
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Cancer Care of North Florida, P.A.
Lake City, Florida 32024
2073
mi
from 91732
Lake City, FL
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Baptist Health System, Inc.
Lexington, Kentucky 40503
1882
mi
from 91732
Lexington, KY
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Glendale Adventist Medical Center
Los Angeles, California 90033
13
mi
from 91732
Los Angeles, CA
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Hematology and Oncology Specialists
Metairie, Louisiana 70006
1648
mi
from 91732
Metairie, LA
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Clinical Trials and Research Associates, Inc.
Montebello, California 90640
7
mi
from 91732
Montebello, CA
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Community Hospital
Munster, Indiana 46321
1733
mi
from 91732
Munster, IN
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Tennessee Oncology, PLLC
250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
1705
mi
from 91732
Nashville, TN
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Florida Cancer Institute- New Hope
New Port Richey, Florida 34655
2118
mi
from 91732
New Port Richey, FL
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Ocala Oncology Center Pl
Ocala, Florida 34474
2126
mi
from 91732
Ocala, FL
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North Country Oncology-Hematology
Oceanside, California 92056
70
mi
from 91732
Oceanside, CA
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Berkshire Hematology Oncology, PC
Pittsfield, Massachusetts 01201
2466
mi
from 91732
Pittsfield, MA
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Texas Oncology-Plano East
Plano, Texas 75075
1227
mi
from 91732
Plano, TX
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Delta Hematology Oncology Associates, PC
Portsmouth, Virginia 23704
2336
mi
from 91732
Portsmouth, VA
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Pacific Hematology Oncology Associates
San Francisco, California 94115
356
mi
from 91732
San Francisco, CA
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Central Coast Medical Oncology
Santa Maria, California 93454
150
mi
from 91732
Santa Maria, CA
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Virginia Mason Medical Center
Seattle, Washington 98101
(888) 862-2737
Virginia Mason Medical Center Established in 1920, Virginia Mason began as an 80-bed hospital with...
961
mi
from 91732
Seattle, WA
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Rockwood Cancer Treatment Center
Spokane, Washington 99204
939
mi
from 91732
Spokane, WA
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Medical Oncology Associates PS
Spokane, Washington 99208
939
mi
from 91732
Spokane, WA
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Hematology Oncology Associates, PC
Stamford, Connecticut 06902
2455
mi
from 91732
Stamford, CT
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Syracuse Veterns Affairs Medical Center
Syracuse, New York 13210
2320
mi
from 91732
Syracuse, NY
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The Tweed Hospital
Tweed Heads, New South Wales 2485
7196
mi
from 91732
Tweed Heads,
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Texas Oncology-Tyler
Tyler, Texas 75702
1315
mi
from 91732
Tyler, TX
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Texas Oncology-Waco
Waco, Texas 76712
1217
mi
from 91732
Waco, TX
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