Study of Ambrisentan in Subjects With Pulmonary Hypertension



Status:Active, not recruiting
Conditions:High Blood Pressure (Hypertension), High Blood Pressure (Hypertension)
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:11/22/2018
Start Date:November 17, 2008
End Date:October 2019

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ABS-LT: A Phase 3, Long-Term, Open Label, Multicenter Safety Study of Ambrisentan in Subjects With Pulmonary Hypertension

This Phase 3, international, multicenter, open-label study will monitor the long-term safety
of ambrisentan in adults with pulmonary hypertension. The available ambrisentan doses for
this study are 5 or 10 mg administered orally once daily; the approved doses of ambrisentan
in the United States, Canada, and the European Union are 5 and 10 mg. Investigators will be
able to adjust ambrisentan dose as clinically indicated. A minimum of 4 weeks between dose
adjustments is required. Participants receiving other therapies for pulmonary hypertension
that are not contraindicated for concomitant use with ambrisentan are permitted to enroll in
this study and continue to receive such therapies. Participants enrolled in this study will
receive treatment with ambrisentan until such time as the investigator or participant chooses
to stop ambrisentan treatment, ambrisentan becomes commercially available, or the Sponsor
stops the study.


Inclusion Criteria:

- Men and women with pulmonary hypertension (PH) who are discontinuing a clinical study
of ambrisentan due to study closure by the Sponsor. Eligible subjects are those
participating in countries where ambrisentan is not yet commercially available.
Subjects participating in countries where ambrisentan is commercially available may be
eligible if they do not qualify for treatment per the current prescribing information
of that country.

Exclusion Criteria:

- Subjects who have discontinued an ambrisentan clinical study for any other reason than
Sponsor-initiated study closure are not eligible.
We found this trial at
17
sites
101 Jessup Hall
Iowa City, Iowa 52242
(319) 335-3500
University of Iowa With just over 30,000 students, the University of Iowa is one of...
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Iowa City, IA
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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Birmingham, AL
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800 Washington St
Boston, Massachusetts 02111
(617) 636-5000
Tufts Medical Center Tufts Medical Center is an internationally-respected academic medical center – a teaching...
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Boston, MA
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75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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Boston, MA
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593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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Providence, RI
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Atlanta, GA
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Aurora, CO
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Boston, Massachusetts 02115
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Boston, MA
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1 Boston Medical Center Place
Boston, Massachusetts 02118
617.638.8000
Boston University Medical Center Boston Medical Center is an extraordinary community of health care providers...
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Boston, MA
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Buenos Aires,
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263 Farmington Ave
Farmington, Connecticut 06030
(860) 679-2000
University of Connecticut Health Center UConn Health is a vibrant, integrated academic medical center that...
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Farmington, CT
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Lexington, South Carolina 29072
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Lexington, SC
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201 Lyons Ave
Newark, New Jersey 07112
(973) 926-7000
Newark Beth Israel Medical Center Newark Beth Israel Medical Center, a regional care, teaching hospital...
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Newark, NJ
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Phoenix, Arizona 85013
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Phoenix, AZ
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Pittsburgh, PA
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92 Lomb Memorial Drive
Rochester, New York 14623
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Rochester, NY
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Saint Louis, Missouri 63110
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Saint Louis, MO
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