Study of Fampridine-SR Tablets in Multiple Sclerosis Patients

Multiple sclerosis (MS) is a disorder of the body's immune system that affects the central
nervous system (CNS). Normally, nerve fibers carry electrical impulses through the spinal
cord, providing communication between the brain and the arms and legs. In people with MS,
the fatty sheath that surrounds and insulates the nerve fibers (called "myelin")
deteriorates, causing nerve impulses to be slowed or stopped. As a result, patients with MS
may experience periods of muscle weakness and other symptoms such as numbness, loss of
vision, loss of coordination, paralysis, spasticity, mental and physical fatigue and a
decrease in the ability to think and/or remember. These periods of illness may come
(exacerbations) and go (remissions). Fampridine-SR is an experimental drug that has been
reported to possibly improve muscle strength and walking ability for some people with MS.
This study will evaluate the effects and possible risks of taking Fampridine-SR in MS
patients

Inclusion Criteria:

- Patient with clinically defined multiple sclerosis

- All patients must be able to complete two trials of a timed 25 foot walk

Exclusion Criteria:

- Female patients who are either pregnant or breastfeeding.