Gene Mutations in Patients With Advanced Prostate Cancer That Is Not Responsive to Hormone Therapy
| Status: | Completed |
|---|---|
| Conditions: | Prostate Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/21/2016 |
| Start Date: | January 1997 |
| End Date: | June 2006 |
Androgen Receptor Mutations in Hormone Refractory Prostate Cancer
RATIONALE: Gene mutations may make prostate cancer cells unable to attach to androgens. This
may permit the growth of prostate cancer. Gene testing may improve the identification of
patients with advanced prostate cancer.
PURPOSE: Clinical trial to study the androgen receptor gene in patients with prostate cancer
that is not responsive to hormone therapy.
may permit the growth of prostate cancer. Gene testing may improve the identification of
patients with advanced prostate cancer.
PURPOSE: Clinical trial to study the androgen receptor gene in patients with prostate cancer
that is not responsive to hormone therapy.
OBJECTIVES:
1. the feasibility of collecting bone marrow biopsies from prostate cancer patients in a
cooperative group setting
2. the incidence of marrow invasion by prostate tumor in random bone marrow biopsy
3. the influence of previous prostate radiation on obtaining prostate tumor
4. the frequency and type of AR mutations and
5. association of AR mutations with response to antiandrogen withdrawal.
1. the feasibility of collecting bone marrow biopsies from prostate cancer patients in a
cooperative group setting
2. the incidence of marrow invasion by prostate tumor in random bone marrow biopsy
3. the influence of previous prostate radiation on obtaining prostate tumor
4. the frequency and type of AR mutations and
5. association of AR mutations with response to antiandrogen withdrawal.
1. Histologically proven adenocarcinoma of the prostate that is refractory to hormone
therapy
2. Patients who are eligible for anticancer therapy on Protocol CLB-9480, CLB-9583,
CLB-9680, or CLB-9780 are also eligible for this study if they have not started
treatment on those protocols
We found this trial at
49
sites
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Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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Duke Comprehensive Cancer Center Leading-edge cancer care and research have been a hallmark of Duke...
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North Shore University Hospital North Shore-LIJ Health System includes 16 award-winning hospitals and nearly 400...
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CCOP - Mount Sinai Medical Center The Mount Sinai Community Clinical Oncology Program (MSCCOP) is...
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Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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171 Ashley Avenue
Charleston, South Carolina 29425
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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University of Iowa Hospitals and Clinics University of Iowa Hospitals and Clinics—recognized as one of...
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Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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Univ of Nebraska Med Ctr A vital enterprise in the nation’s heartland, the University of...
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3700 O Street Northwest
Washington, District of Columbia 20007
Washington, District of Columbia 20007
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6900 Georgia Ave NW
Washington, District of Columbia 20307
Washington, District of Columbia 20307
(202) 782-6849
Walter Reed Army Medical Center The Walter Reed National Military Medical Center is one of...
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Winston-Salem, North Carolina 27157
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