An Investigational Immuno-therapy Study of BMS-986205 Given in Combination With Nivolumab and in Combination With Both Nivolumab and Ipilimumab in Cancers That Are Advanced or Have Spread



Status:Recruiting
Conditions:Lung Cancer, Skin Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 100
Updated:2/3/2019
Start Date:February 18, 2016
End Date:February 28, 2020
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information, please email:
Email:Clinical.Trials@bms.com

Use our guide to learn which trials are right for you!

A Phase 1/2a Study of BMS-986205 Administered in Combination With Nivolumab (Anti-PD-1 Monoclonal Antibody) and in Combination With Both Nivolumab and Ipilimumab (Anti-CTLA-4 Monoclonal Antibody) in Advanced Malignant Tumors

The purpose of the study is to determine safety and effectiveness of experimental medication
BMS-986205 when combined with Nivolumab and in combination with both Nivolumab and Ipilimumab
in patients with cancers that are advanced or have spread. Pharmacokinetics and
pharmacodynamics of BMS-986205 when combined with Nivolumab and in combination with Nivolumab
and Ipilimumab in this patient population will also be assessed.


For more information regarding Bristol-Myers Squibb (BMS) Clinical Trial participation,
please visit www.BMSStudyConnect.com

Inclusion Criteria:

- During dose escalation, subjects with advanced solid tumors that have progressed
following at least one standard regimen

- During cohort expansion, subjects with advanced cancer that either have received at
least one prior therapy or are treatment naive, depending on the specified tumor type

- Subjects must have measurable disease

- Subject must consent to provide previously collected tumor tissue and a tumor biopsy
during screening.

- At least 4 weeks since any previous treatment for cancer

- Must be able to swallow pills or capsules

- Eastern Cooperative Oncology Group(ECOG) Performance Status 0-1

Exclusion Criteria:

- Active or chronic autoimmune diseases

- Uncontrolled or significant cardiovascular disease

- History of any chronic Hepatitis, active Hepatitis B or C, human immunodeficiency
virus (HIV), or acquired immune deficiency syndrome (AIDS)

- Chronic hepatitis: Positive test for Hepatitis B virus surface antigen or Hepatitis C
antibody (except for subjects with hepatocellular carcinoma)

- Active central nervous system (CNS) metastases and CNS metastases as the only sites of
disease

- Active infection

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
19
sites
Tucson, Arizona 85724
Phone: 520-694-1231
?
mi
from
Tucson, AZ
Click here to add this to my saved trials
5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
Phone: 773-702-1649
University of Chicago One of the world's premier academic and research institutions, the University of...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
9500 Euclid Avenue
Cleveland, Ohio 44106
216.444.2200
Phone: 216-636-5655
Cleveland Clinic Cleveland Clinic is committed to principles as presented in the United Nations Global...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
4100 John R
Detroit, Michigan 48201
800-527-6266
Phone: 313-576-8411
Barbara Ann Karmanos Cancer Institute Karmanos is based in southeast Michigan, in midtown Detroit, and...
?
mi
from
Detroit, MI
Click here to add this to my saved trials
1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Phone: 615-875-1655
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
?
mi
from
Nashville, TN
Click here to add this to my saved trials
Atlanta, Georgia 30322
Phone: 404-788-2695
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
1000 Johnson Ferry Rd NE
Atlanta, Georgia 30342
(404) 851-8000
Phone: 404-256-4777
Northside Hospital Northside Hospital-Atlanta (in Sandy Springs) opened in 1970. The original facility had 250...
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
370 Victoria Street
Darlinghurst, New South Wales 2010
Phone: +61293555706
?
mi
from
Darlinghurst,
Click here to add this to my saved trials
30 Prospect Ave
Hackensack, New Jersey 07601
(201) 996-2000
Phone: 551-996-5809
Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
?
mi
from
Hackensack, NJ
Click here to add this to my saved trials
Jacksonville, Florida 32256
Phone: 904-953-2000
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
La Jolla, California 92093
Phone: 858-534-0227
?
mi
from
La Jolla, CA
Click here to add this to my saved trials
Lutherville, Maryland 21093
Phone: 410-955-6605
?
mi
from
Lutherville, MD
Click here to add this to my saved trials
70 Washington Square S
New York, New York 10012
(212) 998-1212
Phone: 646-754-7146
New York University More than 175 years ago, Albert Gallatin, the distinguished statesman who served...
?
mi
from
New York, NY
Click here to add this to my saved trials
Philadelphia, Pennsylvania 19111
Phone: 215-728-2195
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Phoenix, Arizona 85016
Phone: 480-515-6296
?
mi
from
Phoenix, AZ
Click here to add this to my saved trials
Pittsburgh, Pennsylvania 15232
Phone: 412-623-3144
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
Rochester, Minnesota 55905
Phone: 507-284-2511
?
mi
from
Rochester, MN
Click here to add this to my saved trials
Saint Louis, Missouri 63110
Phone: 314-362-9504
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials
Tampa, Florida 33612
Phone: 813-745-2010
?
mi
from
Tampa, FL
Click here to add this to my saved trials