An Investigational Immuno-therapy Study of BMS-986205 Given in Combination With Nivolumab and in Combination With Both Nivolumab and Ipilimumab in Cancers That Are Advanced or Have Spread



Status:Recruiting
Conditions:Lung Cancer, Skin Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 100
Updated:2/3/2019
Start Date:February 18, 2016
End Date:February 28, 2020
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information, please email:
Email:Clinical.Trials@bms.com

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A Phase 1/2a Study of BMS-986205 Administered in Combination With Nivolumab (Anti-PD-1 Monoclonal Antibody) and in Combination With Both Nivolumab and Ipilimumab (Anti-CTLA-4 Monoclonal Antibody) in Advanced Malignant Tumors

The purpose of the study is to determine safety and effectiveness of experimental medication
BMS-986205 when combined with Nivolumab and in combination with both Nivolumab and Ipilimumab
in patients with cancers that are advanced or have spread. Pharmacokinetics and
pharmacodynamics of BMS-986205 when combined with Nivolumab and in combination with Nivolumab
and Ipilimumab in this patient population will also be assessed.


For more information regarding Bristol-Myers Squibb (BMS) Clinical Trial participation,
please visit www.BMSStudyConnect.com

Inclusion Criteria:

- During dose escalation, subjects with advanced solid tumors that have progressed
following at least one standard regimen

- During cohort expansion, subjects with advanced cancer that either have received at
least one prior therapy or are treatment naive, depending on the specified tumor type

- Subjects must have measurable disease

- Subject must consent to provide previously collected tumor tissue and a tumor biopsy
during screening.

- At least 4 weeks since any previous treatment for cancer

- Must be able to swallow pills or capsules

- Eastern Cooperative Oncology Group(ECOG) Performance Status 0-1

Exclusion Criteria:

- Active or chronic autoimmune diseases

- Uncontrolled or significant cardiovascular disease

- History of any chronic Hepatitis, active Hepatitis B or C, human immunodeficiency
virus (HIV), or acquired immune deficiency syndrome (AIDS)

- Chronic hepatitis: Positive test for Hepatitis B virus surface antigen or Hepatitis C
antibody (except for subjects with hepatocellular carcinoma)

- Active central nervous system (CNS) metastases and CNS metastases as the only sites of
disease

- Active infection

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
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Jacksonville, Florida 32256
Phone: 904-953-2000
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
Phone: 773-702-1649
University of Chicago One of the world's premier academic and research institutions, the University of...
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9500 Euclid Avenue
Cleveland, Ohio 44106
216.444.2200
Phone: 216-636-5655
Cleveland Clinic Cleveland Clinic is committed to principles as presented in the United Nations Global...
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4100 John R
Detroit, Michigan 48201
800-527-6266
Phone: 313-576-8411
Barbara Ann Karmanos Cancer Institute Karmanos is based in southeast Michigan, in midtown Detroit, and...
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1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Phone: 615-875-1655
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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Atlanta, Georgia 30322
Phone: 404-788-2695
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1000 Johnson Ferry Rd NE
Atlanta, Georgia 30342
(404) 851-8000
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Northside Hospital Northside Hospital-Atlanta (in Sandy Springs) opened in 1970. The original facility had 250...
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370 Victoria Street
Darlinghurst, New South Wales 2010
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30 Prospect Ave
Hackensack, New Jersey 07601
(201) 996-2000
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La Jolla, California 92093
Phone: 858-534-0227
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Lutherville, Maryland 21093
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70 Washington Square S
New York, New York 10012
(212) 998-1212
Phone: 646-754-7146
New York University More than 175 years ago, Albert Gallatin, the distinguished statesman who served...
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Philadelphia, Pennsylvania 19111
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Phoenix, Arizona 85016
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Pittsburgh, Pennsylvania 15232
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Rochester, Minnesota 55905
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Saint Louis, Missouri 63110
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Tampa, Florida 33612
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Tucson, Arizona 85724
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